Sentences with phrase «gene expression patterns of»

Moreover, when analyzed with gene expression patterns of normal brain cells, the four GBM subtypes associate with different cell lineages.

The research also showed that gene expression patterns of individual tumors varied considerably, and could exceed the variation observed between different cancer types.

Evaluating changes in gene expression patterns of Kif5b and Psmd6: Are they regulated by GOLGA3?

By comparing the gene expression patterns of normal beta cells and insulin - producing cells derived from alpha cells, the researchers confirmed nearly complete cellular reprogramming.

Analysis of liver gene expression patterns of the exposed rats found that the endocrine disruptors induced developmental reprogramming of the animals» epigenomes.

The RPE cells generated by Takahashi's team show the characteristic structure and gene expression pattern of authentic human RPE cells.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Even more striking, the gene - expression pattern in the hippocampi of THC - treated aged mice was radically different from that of untreated elderly mice.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

PATTERNS of gene expression in a woman's blood may give a clue as to whether she is likely to get pregnant using IVF.

Once the pattern of expression of these genes had been identified, Prof. Khatri and his colleagues tested it out on the remaining 900 samples from patients with different tropical diseases and from healthy people.

However, microgravity can reduce cell growth, alter gene expression and change the pattern of root growth — all aspects which critically affect plant cultivation in space.

The patterns of gene expression matched and often preceded physiological changes in the intestine, the researchers wrote.

The gene expression patterns, like the structural changes, then returned to pre-eating state within 10 days after eating, «indicating a tight association between differential gene expression and the rapid and cyclic physiological remodeling of the intestine,» the researchers said.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

To identify genes involved in the patterning of adult structures, Gal4 - UAS (upstream activating site) technology was used to visualize patterns of gene expression directly in living flies.

This work shows the power of using the tools of computational genomics to analyze gene expression patterns for the purpose of elucidating the evolution of behavior.

They used a computer to trawl through 2,100 of the samples and look for patterns of gene expression.

The trick is to run the tape of evolution over again: to intervene in the development of a chicken embryo, for instance, to reverse evolution, rolling back the clock to manifest earlier patterns of gene expression.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

Despite the anatomical complexity of the brain and the complexity of the human genome, most of the patterns of gene usage across all 20,000 genes could be characterized by just 32 expression patterns.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

«We discovered that beta blockers largely reverse the pathological pattern of gene expression observed in heart failure,» said Faculty of Science Professor John McDermott, who led the research, along with York U collaborators Professor Gary Sweeney and Professor Jorg Grigull.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

They found that gene expression is different at 209 sites in chronically lonely people and that many of those changes fit a pattern of elevated immune activation, inflammation, and depressed response to infection.

Then they explored what happened to this pattern of gene expression when beta blocker treatment was implemented, and what they found not only surprised them, but could have important ramifications for future treatments of heart disease.

By examining gene expression patterns, the new study found that parrot brains are structured differently than the brains of songbirds and hummingbirds, which also exhibit vocal learning.

To the researchers» surprise, they found distinct patterns of expression among 17 genes.

These areas in parrots also show some special patterns of gene expression, which the scientists speculate might explain why some parrots are also able to learn to dance to music.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

Another version, the CTC - iChip, rapidly isolates CTCs in a way that does not rely on preidentified tumor antigens, allowing capture of cells with gene expression patterns that may be missed by the antibodies used in the HBCTC - Chip.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tips.

Researchers have videotaped cultures in which embryos develop but found no visual pattern that hints at which cells are about to sprout, and staining for certain patterns of gene expression has been inconclusive.

It isn't clear exactly why the differences fade, Hochedlinger says, but it may be that the expression of embryonic genes is strengthened as the cells grow in culture, gradually overwriting the cells» old gene - expression patterns.

The scientists then studied the patterns of gene expression in these mice.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changes.

This pattern of gene expression is likely a reaction to reduced glucose availability, supporting the model of reduced movement of molecules in the bacteria's extracellular environment.

A distinctive pattern of changes in gene expression occurs in those RA patients who have a good - response to a TNF inhibitor at three months, but not in non-responders

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-expression profiles, seen in the Allen Gene Expression Atlas of the Mouse Brain.»

However, that assay doesn't pinpoint the moment of activation or provide a straightforward way to quantify the connections between microglial activation and gene expression patterns.

Using breast cancer patient data taken from The Cancer Genome Atlas, molecular biologists Curt M. Horvath and Robert W. Tell used powerful computational and bioinformatics techniques to detect patterns of gene expression in two cancer subtypes.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

Horvath and Tell observed that there are many clearly visible patterns of common gene expression — where certain genes are turned on and certain genes are turned off — in the basal - like cancers.

When these mice develop, their internal organs and patterns of gene expression fall randomly into left - or right - oriented layouts.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.