Sentences with phrase «gene expression profile for»

From this data, a relative gene expression profile for each sample is made.

Not exact matches

One of these, his most influential, outlines his original use of microarray expression profiles as a phenotypic footprint for gene function.

Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicals.

Lead author Johan den Boon, associate scientist with the Morgridge Institute for Research at the University of Wisconsin - Madison, says the research team used gene expression profiling on 128 specimens from the Study to Understand Cervical Cancer Early Endpoints and Determinants, or SUCCEED.

The researchers comprehensively analyzed 254 TCGA lower - grade gliomas for gene, protein and micro RNA expression, DNA methylation and gene copy profiles to cluster cases by category.

The team used gene expression profiling and found that canine B - cell lymphoma expression profiles were similar in many ways to human B - cell lymphoma, thus paving the way for future studies, including therapeutic clinical trials in dogs and humans.

«It has taken us years to assemble the clinical outcome database and tissue samples, generate the immunohistochemical biomarkers, gene expression profiles and analyse the data for this study — and we were delighted to find a definite link between alpha beta crystallin and breast cancer progression, which we hope will ultimately improve clinical outcomes.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

They compared space - flown endothelial cells to endothelial cells cultured under normal gravity, looking for differences in gene expression and / or in the profile of secreted proteins.

The case for direct interaction was bolstered by similarities between gene expression profiles of plants with various deficiencies in photoreceptors and COP1.

When compared to young people, it showed that the gene expression profile, after resistance training for six months, was reversed back to that of a more youthful state.

The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

Development of a gene expression assay in non-human primates: We will develop a novel sensitive assay for the characterisation of vaccination - related gene expression profiles in NHPs, using an approach that is fully harmonised with the systems biology platform.

Using gene expression profile (GEP) tests like Oncotype DX to inform treatment decision - making for breast cancer is likely to be less cost - effective in community oncology practice than previous estimates had suggested, according to an economic simulation analysis published in the Journal of Clinical Oncology.

BioSpyder Technologies, Inc. is a relatively small biotech company that features a potent assay for high - throughput gene expression profiling.

Gene - expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.

The Gladstone team had profiled changes in gene expression using DNA microarrays, which provides an unbiased method for identifying key biological pathways.

Using an array of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these tumors and the clinical outcomes of patients.

Comparison of mRNA and protein expression revealed distinct expression profiles for many genes and underscores the importance of multi-omic analysis in single cells.

A cell - surface antibody panel was created and used for protein profiling alongside gene expression profiling.

For example, mutants may be characterized by comparing their transcript profiles to those obtained in other experiments querying the effects on gene expression of many experimental factors including treatments, mutations and pathogen infections.

Proteomic analysis to profile protein abundance resulted in the identification and relative quantification for 912 proteins with two or more unique peptides and 86 proteins with significant abundance changes after treatment with the neurotoxins, while microarray analyses to profile gene expression revealed 181 genes with significant changes in mRNA after treatment.

With DriverMap, Cellecta offers a novel, comprehensive end - to - end service portfolio for identifying differential gene expression, mapping of clinically actionable mutations in RNA, detecting cellular composition, and profiling immunotherapy targets.

Gene expression profiles measured using human genome Affymetrix Gene Chip arrays were grouped by hierarchical clustering, and correlation coefficients were computed for all pair-wise comparisons (Fig. 4A).

Quantitative real time PCR (qRT - PCR) is accepted as the gold standard for expression profiling, so we next compared both our RNAseq and the microarray expression estimates to a panel of qRT - PCR TaqMan gene expression assays (Figure 2C — F).

For this study, Encode will isolate peripheral blood mononuclear cells from patients and generate gene expression profiles of cells through in vitro exposure to the candidate drug.

Another group investigated CD8 + T cells, and found that babies had epigenetic and gene expression profiles that resembled those of innate immune cells, which «may provide a partial explanation for infants» higher susceptibility to infectious pathogens,» GenomeWeb reported.

Doing so opened up a vast bank of viable samples for gene expression profiling, from which Dr. Golub and colleagues made some interesting findings.

High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein - DNA interactions alter Epigenetic profiles and subsequent gene expression.

After clicking on any of the panels, for example on the top left panel marked with a red asterisk, the expression profiles of the individual genes that follow the corresponding pattern as well as their names appear in a new window (as shown in B).

We have developed a novel «integrated» approach for gene expression profiling analysis that combines both «unbiased» and «biased» profiling (22)[Fig. 5].

The set of possible analyses include: 1) comparison of cell populations for the identification of differentially expressed genes; 2) dimensionality reduction for the identification of relevant coordinates; and 3) clustering of subpopulations on the base of gene expression profiles.

Rohit presented his work on using machine learning applications for predicting prognosis in primary melanoma based on gene expression profiles derived from primary melanoma tumours.

Their gene expression analysis throughout the protocol matched that of a previously published profile for hESCs [24], which included the significant upregulation of mesodermal and chondrogenic markers (PDGFRB, SOX6, SOX9, ACAN, COL2A1 types A and B), with the more mature COL2A1 type B splice variant [42] being more highly expressed by the end of stage 3.

She emphasized several times the value of TCGA's GBM sequencing as a reference cancer genome, with high - quality mutations already profiled for mutations, gene expression, etc..

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Gene expression profiles are provided for all RNA samples combined, or separately for the CGR8 and E14TG2a ES cell lines.

Title: Digital spatial profiling platform allows for spatially - resolved, high - plex quantification of mRNA distribution and abundance on FFPE and fresh frozen tissue sections Date / Time: Tuesday, April 17 2018, 8am - 12:00 pm CT Author: Daniel Zollinger, NanoString Poster # / Location: 3434 / Section 18, Board 16 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7119 Digital Spatial Profiling can be used to obtain high - plex, spatial mRNA expression data (10's to 100's of genes) and protein expression data on FFPE and fresh frozen tissue profiling platform allows for spatially - resolved, high - plex quantification of mRNA distribution and abundance on FFPE and fresh frozen tissue sections Date / Time: Tuesday, April 17 2018, 8am - 12:00 pm CT Author: Daniel Zollinger, NanoString Poster # / Location: 3434 / Section 18, Board 16 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7119 Digital Spatial Profiling can be used to obtain high - plex, spatial mRNA expression data (10's to 100's of genes) and protein expression data on FFPE and fresh frozen tissue Profiling can be used to obtain high - plex, spatial mRNA expression data (10's to 100's of genes) and protein expression data on FFPE and fresh frozen tissue sections.

In this study, we have shown for the first time the gene expression profile in isolated rat adipocytes treated with anthocyanins (cyanidin 3 - glucoside; C3G or cyanidin; Cy).

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.