Sentences with phrase «gene expression profiles result»

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

Although the database described here was based on the gene expression profiling results of the FunGenES consortium, it can be easily adapted to incorporate available or future genomics data obtained in ES cells.

Biclustering of drug ‐ induced gene expression profiles resulted in modules of drugs and genes, which were enriched in both drug and gene annotations.

Not exact matches

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

Proteomic analysis to profile protein abundance resulted in the identification and relative quantification for 912 proteins with two or more unique peptides and 86 proteins with significant abundance changes after treatment with the neurotoxins, while microarray analyses to profile gene expression revealed 181 genes with significant changes in mRNA after treatment.

To better illustrate gene expression profiles in mouse ES cells, we have organized the results in an interactive database with a number of features and tools.

Results: Here, we profile genome - wide changes in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse liver.

Since there is a higher than 95 % chance that cluster assignments are accurate (Supplemental File S2), and our validation analysis shows that 90.7 % of the array expression patterns match the RNA analysis results using other techniques (e.g., Q - PCR), we estimate that more than 86 % of the genes in a cluster follow the corresponding average expression profile.

The results show comparable gene expression profiles between microarray and Q - PCR data.