Sentences with phrase «gene expression programs»

Werner, S. L., Barken, D. & Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity.

(2017) Enhancer transcription reveals subtype - specific gene expression programs controlling breast cancer pathogenesis.

To better visualize changes in gene expression programs during differentiation, we performed k - means clustering analysis, followed by hierarchical clustering, to group genes by their timing of induction or suppression during the normal ES cell differentiation process.

As a Howard Hughes Medical Institute investigator and biochemistry professor at Stanford, Pat led a team that developed the first methods for analyzing, visualizing and interpreting global gene expression programs.

Concurrently, this dermal cell aggregation triggers the mechanosensitive activation of β - catenin in adjacent epidermal cells, initiating the follicle gene expression program.

Activation of a TGF --LCB- beta -RCB-- Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid - Mediated Surface Expression of TGF --LCB- beta -RCB- Receptor II.

We use the fission yeast, Schizosaccharomyces pombe, to study the dynamic changes and plasticity of gene expression programs as a function of cell proliferation, quiescence and ageing, and the effect of various genetic and environmental perturbations.

How developmental signaling pathways interact with chromatin to establish and maintain lineage - specific gene expression programs remains unclear.

We are currently testing the hypothesis that these transcription factors form a genomic regulatory network, and disruption of that network by mutation destabilizes gene expression programs, contributing to malignancy.

Differential histone variant deposition in normal and disease states and their impact on gene expression programs and genome stability

«This suggests that two different gene expression programs may exist; one for normal cellular activity and one for regeneration,» explains Stewart.

MicroRNAs and long non-coding RNAs (lncRNAs) have the capacity to regulate gene expression programs, and their differential expression within immune cells highlights their potential in defining immune cell identity and function.

«Our data showed that resistant genotypes, or genes prone to being cancer - resistant, were pre-existing and adaptively selected by the initial treatment known as neo-adjuvant chemotherapy, but also requires further changes in gene expression programs to become fully resistant.»

This line of research will reveal how developmental signaling pathways interact with chromatin to establish specific gene expression programs.

Scientists from Freie Universität Berlin have identified a mechanism that allows cells to adapt their gene expression program to very small changes in temperature.

More recently, the analysis of the super-enhancer landscape allowed to decipher the core regulatory circuitries controlling the gene expression program of neuroblastoma.

The findings, reported in the Oct. 5 issue of Current Biology, define a gene expression program that controls the timing of synaptic remodeling.

When histone H3.3 is methylated, ZMYND11 recognizes and binds to the methylation mark to turn off a gene expression program that helps tumors grow.

Unfortunately, conventional sorting techniques have not been sufficient to isolate the individual islet cell types, making it impossible to analyze each one's gene expression program and its potential contribution to dysfunction.

These effects are reversed by cross-fostering, [7], [9] demonstrating a causal link between maternal care and gene expression programming.