Sentences with phrase «gene expression signatures»

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

In 2006 Potti's team published several papers in high - profile journals reporting that certain gene expression signatures predicted a patient's response to chemotherapy.

«Studies are now underway to start a clinical trial to determine whether the novel gene expression signature described in this work may help initiate new and better immunotherapy treatments.»

Finally, the authors suggest that a pre-treatment gene expression signature of cancer stem cells might be able to help predict the response to ONC201.

Lead researcher Dr Gabriella Ficz from QMUL's Barts Cancer Institute said: «It's surprising that cells from several healthy individuals are so permissive to gaining this epigenetic change and that one «hit» from an epigenetic editing tool is sufficient to set off this chain reaction of epigenetic inheritance and establish a cancer cell - like gene expression signature.»

After analyzing gene expression signatures in the precursor cells, the investigators demonstrated that they could reliably predict UCP1 expression in the resulting mature cells.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

A.K. Zaas, M. Chen, J. Varkey, T. Veldman, A.O. Hero III, J. Lucas, R. Turner, A. Gilbert, C. Oien, B. Nicholson, S. Kingsmore, L. Carin, C.W. Woods, and G.S. Ginsburg, Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans, Cell Host and Microbe, 2009.

To this end, my laboratory will screen blood from pediatric samples to look for evidence of asthmatic gene expression signatures (as originally defined in adults).

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

«These new findings not only demonstrate the importance of the cancer cell of origin in controlling breast tumor heterogeneity, but also show that the gene expression signature found in the early steps of tumor initiation is predictive of the type of tumors that will eventually develop and the clinical prognosis of women with breast cancers» comments Cédric Blanpain, the senior author of the Nature paper.

The authors defined the gene signature of the different regions surrounding the wound to uncover the gene expression signature of the cells that actively divide and those that migrate to repair the wound.

Researchers at Moffitt Cancer Center and Tianjin Medical University Cancer Institute and Hospital in China have discovered a gene expression signature that may lead to new immune therapies for lung cancer patients.

By defining the gene expression signature of CD4 - CTLs and their precursors, their studies should facilitate improved vaccine design in the context of chronic viral infections.

Three gene expression signatures can help rheumatologists predict which patients are more likely to respond to tumor necrosis factor inhibitors (TNFi) or B - cell depletion therapies in patients with moderate to severe rheumatoid arthritis, according to new research findings presented this week at the 2016 ACR / ARHP Annual Meeting in Washington.

Using support vector machine recursive feature elimination, the researchers identified three gene expression signatures that predicted therapy responses.

Specific projects include the use of gene expression signatures to predict recurrent rectal cancer, the study of gene expression changes in response to chemotherapy and radiation, differential gene expression between primary tumor and metastatic deposits, and analysis of expression patterns to provide more accurate cancer staging.

With the development of novel genomics technologies, such as Next - Generation Sequencing, numerous new mutations and gene expression signatures have been identified, allowing us to better understand the molecular heterogeneity of hematologic diseases and to better stratify and assess risk for cancer patients.

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

A recent in vitro study revealed that exposure of lung epithelial cells to E-cig-conditioned medium induces a gene expression signature similar to tobacco smoke [11].