Sentences with phrase «gene expression within»

What's happening, it seems, is that the vegan diet reprogrammed gene expression within the prostate gland itself.

Tang T - YD, Van Swaay D, de Mello A, Anderson JLR, Mann S In vitro gene expression within membrane - free coacervate protocells Chemical Communications, 51, 11429 — 11432

It is an important factor for the correct regulation of gene expression within all these groups of organisms.

«By looking comprehensively at gene expression within cells, we can now spot numerous important differences in complex tissues like the brain that are invisible today,» said George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School.

Following on from this discovery, the next fundamental question to answer is, how is this signal being transmitted from the chloroplast to the nucleus to change gene expression within the cell?

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

Not exact matches

Within the cell, they can trigger changes in gene expression and biochemical reactions, among other things.

Objective: Research microbiologist with 3 years of postgraduate research in gene expression and metabolism of E. coli would like to apply knowledge within an industry setting.

The gene expression patterns, like the structural changes, then returned to pre-eating state within 10 days after eating, «indicating a tight association between differential gene expression and the rapid and cyclic physiological remodeling of the intestine,» the researchers said.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

Kingsley's research has shown that these adaptive changes are often driven by changes in the regulatory regions that surround and control gene expression, rather than within the coding regions of the genes themselves.

Weaving together perspectives from the fields of gene regulation and chromatin, Turner offers a concise discussion of the relations between the packing and organization of DNA within the cell nucleus and the regulation and expression of genes.

Also from previous work, they knew the genes whose expression within the transition zone was higher than elsewhere in the cell (indicating that they were being «turned on» for this specific purpose).

Prof Tony Green, an author from the Wellcome Trust - MRC Stem Cell Institute and Cambridge University, said: «The SC3 tool was able to use patterns of gene expression to distinguish, within an individual cancer, subclones that carried different mutations.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

The researchers found that the gene expression levels in immune cells changed in response to the macaque's new social rank within 3 months of establishing the new groups, and the cells got better at fighting infection.

But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high - fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

Gene expression profiling tests, such as Oncotype Dx, analyze the patterns of 21 different genes within cancer cells to help predict how likely it is that a women's cancer will recur within 10 years after initial treatment and how beneficial chemotherapy will be to her.

«It is also possible that these data will reveal that some previously identified disease - associated sequence variants actually fall within a formerly unrecognized primary miRNA gene, thereby raising the possibility that such variants may influence expression of the encoded miRNA,» Mendell said.

Gene chips, for instance, can measure the expression of thousands of genes at a time, but the important question is how one gene regulates others within that incredibly complex web of relationshGene chips, for instance, can measure the expression of thousands of genes at a time, but the important question is how one gene regulates others within that incredibly complex web of relationshgene regulates others within that incredibly complex web of relationships.

Differences in gene expression are likely to specify much of the phenotypic differences between and within species.

Identifying adaptive and plastic gene expression levels using a unified model for expression variance between and within species Rohlfs, R. and R. Nielsen.

Modeling gene expression evolution with an extended Ornstein — Uhlenbeck process accounting for within - species variation Rohlfs, R. V., P. Harrigan and R. Nielsen.

The new dependency data complement the Dependency Map team's ongoing efforts to use functional genomic technologies like CRISPR and RNA interference (RNAi) to locate vulnerabilities that arise within cancer cells as they compensate for the loss of critical genes due to mutations or expression changes.

Identifying adaptive and plastic gene expression levels using a unified model for expression variance between and within species.

Calcification rate measurements and gene expression analysis by microarray RNA transcriptional profiling at two time - points (midday and night - time) revealed several genes common within mammalian gene regulatory networks.

Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.

Expression and functional analyses of the gene strongly suggest that PDE4D plays an important role in atherosclerosis, most likely by influencing the proliferation and migration of smooth muscle cells within arteries that is central to the biology of ischemic stroke.

«By knowing which of the Cohesin / CTCF bound sites are coming together in physical proximity, we started to go from a linear view of the genome to sets of looping interactions, which led us to these domains, these super enhancer domains, where gene expression enhancement is contained within the loop,» says Jill Dowen, a postdoctoral researcher in Young's lab.

We also identified a «meditation effect» within the regular meditator group, characterized by a distinct network of genes with cellular functions that may be relevant to healthy aging, and this network was associated with increased expression of a number of telomere maintenance pathway genes and an increase in measured telomerase enzymatic activity.

Specifically, use of post-mortem material is crucial for studying the patterns of normal gene expression underlying tissue specificity within individuals, as sampling such tissues from living individuals would be impossible.

Here we use semi-conserved regions within short var gene sequence «tags» to make direct comparisons of var gene expression in 12 clinical parasite isolates from Kenyan children.

The Chips are cultured under continuous flow within engineered 3D microenvironments that go beyond conventional 3D in vitro models by recapitulating in vivo intercellular interactions, spatiotemporal gradients, vascular perfusion, and mechanical forces — all key drivers of cell architecture, differentiated function, and gene expression.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

Recombinant Deoxyribonucleic Acid (DNA) vaccines contain some or all of the gene (s) for expression of the antigen (s) within a suitable molecule.

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression.

To directly measure the level of coordination in the expression of genes, we used highly sensitive fluorescence in situ hybridization (FISH) to count individual mRNAs of functionally related and unrelated genes within single Saccharomyces cerevisiae cells.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

LOS ALAMOS, N.M., Jan. 31, 2018 — Using a simple analytical framework for random events within a predictable system, computational biologists have found a new way to accurately model certain forms of gene expression, including the body's 24 - hour internal clock.

Understanding the metabolism and gene expression profiles as well as inter-species interactions within these complex microbial communities are necessary steps in studying the diseases and finding new treatment solutions.

An equally consistent pattern of gene expression is observed in the set of ICM markers (contained within Group 2 in Figure 4A, Figure 4C, and Figure S3).

We therefore focused our analysis of differential gene expression on those genes that have at least a 25 % probability of being within the highly - expressed distribution: 17,698 genes in the VNO and 17,983 in the OM (see Materials and methods for details).

We sought first to examine gene expression in single ES cells isolated directly from specific zones within colonies, with two objectives.

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes.

Kennedy is interested in understanding why reduced gene expression in ribosomes enhances longevity in yeast and worms — ribosomes are tiny organelles that occur within the cell and are involved in the production of proteins.

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J. & Marsh - Armstrong, N. (2008) Journal of Neuroscience, 28:548 - 61.

The present study shows that such a gradient is also seen at the level of single cell analysis, but reveals that there is considerable cell - to - cell variation within this gradient in the expression of pluripotency genes.

Results: Within 4 h, activation of CD4 (+) T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi - C.

During development, genes within specific cell types are turned on and off to trigger the necessary expression patterns that create a whole animal.

Researchers have identified some 6600 genes whose level of expression varies within a comparatively restricted range in humans and mice...