Sentences with phrase «gene expression without»

Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up - regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes.

In particular, the lab investigates how alterations in epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian cancer.

Recently, accumulating observations support the notion that STAT proteins can drive gene expression without tyrosine phosphorylation (14 — 19).

During the past decade, data on the putative roles of STAT proteins in mediating gene expression without tyrosine phosphorylation have been accumulating.

The presence of such sequences could provide organisms with a way to modify their gene expression without altering the actual coding sequence of genes.

The study examined DNA methylation — an «annotation» of DNA that alters gene expression without changing the genomic sequence itself — in a group of diverse Latino children.

«This is the first example of how early environment can alter gene expression without mutating the gene itself,» Jirtle says.

And in 2012, they uncovered the first evidence that sleep apnea influences epigenetics, altering gene expression without changing an individual's DNA.

Monitoring mRNA could tell scientists a great deal about which genes are being expressed in a cell, and tweaking the translation of mRNA would allow them to alter gene expression without having to modify the cell's DNA.

Not exact matches

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

While nicotine and non-nicotine products both produced changes, e-cigarette products without nicotine resulted in even more gene expression changes than products with nicotine, Zelikoff said.

Judith Zelikoff of NYU Langone Medical Center studied pre - and post-natal exposure to mice of commercially available e-cigarette vapors and aerosols with and without nicotine, finding changes to frontal cortex gene expression associated with mental health and activity issues, some of which are associated with schizophrenia, she said.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

When the researchers started taking weeds out of the corn at early points, such as when the corn had as few as two and four leaves, they still saw differences in gene expression when compared to corn without weeds.

Active NtrC binds to DNA and boosts the expression of certain genes that allow the cell to live without nitrogen.

When the team measured gene expression first in the stem cells, and then re-evaluated the cells once they had become neurons, very specific differences emerged between the cells derived from bipolar disorder patients and those without the condition.

Without an adequate supply of the S - adenosyl methionine, regulation by histone methylation — and therefore correct gene expression — can not take place.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.

The study was also the first to study gene expression in children over the course of their allergic reactions, allowing each subject's reaction to be compared to their own pre-reaction state, rather than to a control group without peanut allergies.

By slightly changing these master genes, evolution could have an outsized effect on overall expression without as much chance of negative mutations, Gilad says.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

Additionally, the interpretation of levels of change in gene expression in isolation, without the additional statistical rigor provided by the concomitant analysis of ontological interaction networks, may severely limit critical insights into relevant biologic processes.

Induction of stem cell gene expression in adult human fibroblasts without transgenes.

In these tests, StemFit not only delivered higher cell proliferation, but also showed characteristics such as homogeneity of gene expression compared with iPS cells cultured with four other media without any chromosomal abnormalities.

On average we found only 54 genes per tissue (0.2 %), which showed significant correlation of gene expression with PMI (FDR < 1 %)(Fig. 3a, Supplementary Table 6), compared to 6919 genes per tissue (39.3 %), if using the same model without covariates.

«Without computer analysis of sequencing results, we would not have been able to determine relationships between DNA methylation, how accessible regions of the genome were, global gene expression, or the emergence of cancer cells,» says González - Avalos, a graduate student in UCSD's Bioinformatics Graduate Program.

To compute the correlation values of gene expression and PMI without the covariates, a procedure similar to the above was used where Pearson correlation is obtained between gene expression and PMI values (Supplementary Fig. 38).

We included genes with and without a known function in olfactory and vomeronasal signaling that cover the whole range of expression values observed (Table S1).

Ethylene and Jasmonic Acid Signaling Affect the NPR1 - Independent Expression of Defense Genes Without Impacting Resistance to Pseudomonas syringae and Peronospora parasitica in the Arabidopsis ssi1 Mutant

Based on this classification of evolutionary age of each gene, induced genes are much younger than either non-regulated or repressed genes: excluding those genes without significant expression, induced genes are only 37.9 % Metazoan compared to 64.5 % Metazoan for non-regulated genes and 55.9 % Metazoan for repressed genes (Figure 4A).

GFP expression robustly activated the reporter gene TdTomato, whose expression was absent without electroporated GFP.

Furthermore, our data from hESC - derived NSCs indicate that reprogramming can be achieved without ectopic expression of the tumor - associated genes, c - Myc and Klf4.

In agreement with this, both wt STAT2 and mutant STAT2 - Y690F displayed a similar effect on the luciferase reporter gene expression in U3A cells without IFNα.

The activated AHR / NuRD complex altered the expression of differentiation - specific genes that control the first two developmental decisions without affecting the pluripotency program.

The team identified 85 small molecules that increased noise without changing average GFP gene expression levels.

They discovered that increasing the random activity, or noise, associated with HIV gene expression — without increasing the average level of gene expression — can reactivate latent HIV.

From a total of 23 samples, we used high - throughput cDNA sequencing (RNA - Seq) on the Illumina platform to profile gene expression between genders and tissues, with and without pairing influence.

Hormesis: an alternative longevity mechanism There are some other lifestyle factors that can also boost the expression of stress resistant genes without the downsides to low levels of growth hormone and IGF - 1.

Food - based botanicals have the potential to restore a healthier gene expression in patients but without the toxicity of certain drugs.

Acute and long - term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression.

In this world, each emoji has only one facial expression — except for Gene, an exuberant emoji who was born without a filter and is bursting with multiple expressions.

Surprisingly, they did this without altering the expression of genes thought to be involved with the calcification process.