Sentences with phrase «gene family encodes»

This was followed by Ph.D. studies at the University of Leicester, completed in 1984 with a thesis entitled «The Gene Family Encoding a Major Glycoprotein in the Murine Submaxillary Glands».

Not exact matches

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

The gene aquaporin - 1 encodes channel - forming integral protein (CHIP), a member of a large family of water transporters found throughout nature.

Snake venoms are complex protein mixtures encoded by several gene families and these proteins function synergistically to cause rapid paralysis or death in prey.

In 2004 the Nobel Prize in Physiology or Medicine went to Linda B. Buck and Richard Axel for their research showing that there is a huge family of genes that encode proteins called olfactory receptors.

Together, the researchers focused on a family of genes that encode taste receptors found in fruit flies.

Closer scrutiny revealed that one gene, encoding a protein called TIGR, was mutated in five of the eight families tested, but not in 100 healthy controls.

A family of neuropeptide genes which includes the gene encoding ELH along with two additional genes encoding the A and B peptides thought to initiate the egg - laying process has been isolated and their nucleotide sequence has been determined.

The MHC is a family of genes found in all vertebrates that encodes vital proteins in the immune defense system.

Carter's recent experimental studies showed that the two small enzyme ancestors of these two families were encoded by opposite, complementary strands of the same small gene.

At the heart of the pathway lies the daf - 2 gene, which encodes a member of the insulin family of cell surface receptors.

In the October issue of Nature Genetics, Siddique's team writes that a mutated gene on chromosome 2 common to both families encodes a novel protein they dubbed alsin.

And curious as to how widespread this phenomenon might be, the researchers looked for protein families with nearly identical members that are encoded by different genes and had significant variations in ribosome density across the family.

Around 50 % of cases of familial recessive Parkinson's disease are caused by mutations in the PARKIN gene, which encodes a protein that belongs to the RBR ubiquitin ligase enzyme family.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Activation of the UPR induces the production of a family of basic leucine zipper - containing transcription factors that activate transcription of genes encoding functions to reduce the protein - folding load and increase the protein folding capacity of the ER.

The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence.

The variant surface antigens expressed on Plasmodium falciparum - infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome.

In P. vivax, genes encoding the exported protein family «PHIST», and exported proteins in general (as predicted by ExportPred47), have paralogously expanded compared to P. cynomolgi (84 vs 54).

Although antimicrobial peptides are not the only functional class to be overrepresented among short, secreted proteins encoded by members of multi-gene families, the prevalence of these properties among induced genes strongly suggests the possibly that at least some of these genes encode novel immune effectors.

In Nasonia, 38.5 % of genes encoding AMPs are in multi-gene families, compared to 17.1 % of non-immune genes (Fisher's Exact Test P = 0.0081).

PfEMP1s are encoded by a family of 60 var genes that are constantly changing through a process called recombination.

Finally, genes encoding antimicrobial peptides (and indeed many non-signaling components of the immune system) are often members of multi-gene families present across insects [5].

PfEMP1s are encoded by a family of roughly 60 genes called var genes.

The human leukocyte antigen (HLA) system is a gene family that encodes the human major histocompatibility complex (MHC).

Regarding other members of the p53 family, the p63 gene encodes 6 isoforms which migrate on gels in sizes from 32 - 90 kDa [21,30].

The SNP is in the gene encoding claudin 14 (CLDN14), a protein expressed in the kidney and one of a family of membrane proteins that regulate the passage of ions and small solutes between cells.

The family values encoded into the Cayman genes since the very beginning are evident.

ADAMTS17 is one of 29 known mammalian members of the ADAMTS family of genes that encode secreted metalloproteases that proteolytically modify extracellular structural proteins.