Sentences with phrase «gene for obesity»

This fascinating field of epigenomics examines how genes are modified without changing the DNA sequence — that is, how a gene for obesity, for instance, is modified by eating nonstarchy vegetables versus cupcakes.

Other accomplishments in this area include the mapping of variation in the FTO gene for obesity, characterizing the role of interleukin (IL)-6, IL - 10, and IL - 1RA in obesity and insulin resistance in African Americans (AA), and determining the loci associated with CRP, IL - 10, IL - 1Ra, and IL - 6 levels in a GWAS of AA.

The effects of the gene for obesity do not show up much in the starving Third World.

Don't blame gluttony or genes for the obesity epidemic — it's our sedentary habits echoing down the generations, says obesity theorist Edward Archer

These genes are associated with these traits through SNPs, which may be located in intergenic regions, and they do not need to have functional evidence as causal genes for obesity or T2D.

Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins.

Moreover, 127 sites representing 65 candidate genes for obesity were differentially methylated in case - control cohort 2 (q < 0.15, P = 0.5, χ2 test; Supplementary Table 15).

Not exact matches

«Together, our data strongly suggest that cutaneous gene therapy with inducible expression of GLP1 can be used for the treatment and prevention of diet - induced obesity and pathologies,» the authors wrote.

Seven genes for intelligence are also associated with schizophrenia; nine genes also with body mass index, and four genes were also associated with obesity.

Until now, hundreds of labs searching for a leptin defect or another gene that might cause human obesity had come up empty - handed.

We now know how to turn fat cells into ones that burn calories as heat rather than store them — raising the prospect of a gene therapy for obesity

For example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatioFor example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatiofor obesity, and they replicated the results in four human populations.

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes — fam57ba and doc2a — in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

The revolution in obesity research began less than five years ago with the landmark discovery of a gene for leptin, the weight - regulating hormone found in both mice and people.

What does it mean for a gene to be associated with obesity?

«The BDNF gene has previously been linked to obesity, and scientists have been working for several years to understand how changes in this particular gene may predispose people to obesity,» said Jack A. Yanovski, M.D., Ph.D., one of the study authors and an investigator at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

A single variation in the gene for brain - derived neurotropic factor (BDNF) may influence obesity in children and adults, according to a new study funded by the National Institutes of Health.

«The large number of genes makes it less likely that one solution to beat obesity will work for everyone and opens the door to possible ways we could use genetic clues to help defeat obesity,» she says.

«Finding the genes that increase risk of obesity is only the end of the beginning,» says senior author Ruth Loos, Ph.D., professor of preventive medicine at Mt. Sinai Hospital, and director of the Genetics of Obesity and related Metabolic Traits Program in the Charles Bronfman Institute for Personalized Meobesity is only the end of the beginning,» says senior author Ruth Loos, Ph.D., professor of preventive medicine at Mt. Sinai Hospital, and director of the Genetics of Obesity and related Metabolic Traits Program in the Charles Bronfman Institute for Personalized MeObesity and related Metabolic Traits Program in the Charles Bronfman Institute for Personalized Medicine.

By analyzing genetic samples for over half a million individuals as part of the GIANT research project, which aims to identify genes that regulate human body and size, researchers found more than 100 locations across the genome that play roles in various obesity traits.

«A lot of diabetes in the elderly goes undiagnosed because they don't have the classical risk factors for type 2 diabetes, such as obesity,» says Evans, director of Salk's Gene Expression Laboratory and senior author of the new paper, which was published November 18, 2015 in Nature.

«Our findings suggest that certain mutations in the BRCA1 gene may put people at increased risk for metabolic diseases like obesity and type 2 diabetes,» said Dr. Spangenburg.

«Lots of genes have multiple roles, but the idea here is that this gene may be involved in the coordination of roles in traits important for feeding and obesity.»

MEGENA (for Multiscale Embedded Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and AlzheimeGene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimegene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.

For example, higher chocolate intake and a larger waist size was associated with certain forms of the oxytocin receptor gene, and an obesity - associated gene played a role in vegetable and fiber intake.

Animals with gene mutations that significantly alter their circadian rhythms have shorter life spans, and circadian rhythm sleep disorders in humans can have profoundly negative effects, including increased risk for obesity, depression, cardiovascular disease and cancer.

The relationship held: Of the 78 genes the researchers examined for epigenetic marks, only the methylation of the RXRα gene showed a strong relationship with obesity.

Viewed this way, humans can be considered to have lost two genes — one affecting uricase and the other affecting the ability to produce vitamin C — whose absence helped our ancestors during famine but, in today's world, may be increasing our risk for obesity and diabetes.

The team identified multiple germline mutations in the human genes responsible for SNRK production that were directly associated with higher body mass index, higher waist circumference and risk of obesity in a cohort of 12,000 women who participated in the Women's Health Initiative.

SNPs in the human IL15 and IL15RA genes have been associated with muscle phenotypes (16), muscle responses to resistance training (17), metabolic syndrome (16), and obesity (18 — 20), providing additional rationale to support a role for these molecules in muscle.

These fruit flies in a lab at UNLV are good models for studying how genes affect human obesity.

«Finding a SIRT3 gene mutation linked to metabolic syndrome is a big step towards developing treatments for this increasingly common collection of obesity - related illnesses,» said Dr. Verdin, who is also a UCSF professor of medicine.

Among differentially expressed obesity and T2D candidate genes (Supplementary Tables 4 and 5), there were significant associations between methylation and expression for 65 sites corresponding to 17 genes (Supplementary Table 20).

«It's a timely reminder that when contemplating the scene of a crime, it is wise to look beyond those potential culprits standing nearest to the body, some of whom may well be innocent bystanders, and to look for «motive» amongst those who may be standing a little distance away,» Mark McCarthy of the University of Oxford, a researcher who has worked on the connection between obesity and the FTO gene, told National Geographic's Not Exactly Rocket Science.

We also examined whether candidate genes for T2D and / or obesity, previously identified by GWAS (P < 1.0 × 10 − 5 [www.genome.gov/gwastudies]-RRB-, exhibit differential methylation in adipose tissue of unrelated patients with diabetes versus nondiabetic subjects.

Obesity increases the risk for T2D, and, hence, it is possible that altered expression and / or methylation of these genes may contribute to the development of T2D.

Common forms of these genes confer significant predisposition to obesity Reykjavik, ICELAND, December 11, 2003 — deCODE genetics (Nasdaq: DCGN) today announced that it has isolated two new genes as part of its alliance with Merck & Co, Inc. to develop drugs for the...

Prior to modern agriculture, it was very important for the body to keep extra resources, but in today's environment, those genes have been linked to obesity.

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs (Credit: < a href ="https://depositphotos.com/19154541/stock-photo-serious-doctor-examining-a-patient.html" rel="nofollow"> sunabesyou / Depositphotos )

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs (Credit: sunabesyou / Depositphotos)

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs

Reykjavik, ICELAND, December 11, 2003 — deCODE genetics (Nasdaq: DCGN) today announced that it has isolated two new genes as part of its alliance with Merck & Co, Inc. to develop drugs for the treatment of obesity.

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Dr. Tove Fall, lead study researcher at the Department of Medical Sciences and the Science for Life Laboratory at Uppsala University commented, «We knew already that obesity and cardiovascular disease often occur together... in this study we found that individuals with gene variants that lead to increased body - mass index also had an increased risk of heart failure and diabetes.»

It is accepted that the regulation of adipocytokine secretion or the adipocyte specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.

It is accepted that the regulation of adipocytokine secretion or the adipocyte - specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.

Recent research into a field of science called nutrigenomics makes it safe and easy to use a simple home kit to examine your genes for the presence of particular variants that predispose you to weakness in detoxification, Vitamin D metabolism, antioxidant processing, other nutrient imbalances and certain conditions, such as obesity, hypertension, diabetes and cardiovascular disease.

An additional Harvard study concluded that regularly consuming drinks high in sugar interacts with the genes that affect weight, dramatically increasing a person's risk for obesity.

In the Diet, Obesity, and Gene (Diogenes) Project, increased protein consumption together with a modest reduction in glycemic index was beneficial for weight control.49 Substituting protein for carbohydrate also partly resulted in lower blood pressure, improved lipids levels, and concomitantly reduced cardiovascular risk.50 Higher vitamin D intake might have beneficial effects on the reduction of visceral adipose tissue51 and other cardiovascular risk factors52.