To boost production of the enzyme in animals, U.C. Davis scientists have transferred the human
gene for the enzyme into dairy goats.
Scientists identified the human
gene for this enzyme in 2000, and since then it's been linked to human diseases including autoimmune disorders, HIV infection and cancers.
From such studies came the current canonical model of how venom genes evolve through the chance replication and mutation
of genes for enzymes, peptides and other proteins.
Individuals with GSDIa have a
defective gene for the enzyme glucose -6-phosphatase, resulting in the inability to regulate blood sugar (glucose).
DTX 401 is designed to address the defective
gene for the enzyme glucose -6-phosphatase-α, a defect that results in the inability to regulate blood sugar (glucose).
In another landmark success, scientists in Italy and the United States cured «bubble» babies who have a
malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cells.
Doctors gave the patients stem cells containing copies of a properly
functioning gene for the enzyme; the babies» immune systems were then able to reconstitute themselves.
Guessing that worm burgers would never catch on, Jing Kang and colleagues at Harvard Medical School in Boston inserted the
worm gene for an enzyme that turns omega - 6 fatty acids into omega - 3's in mice.
This is clear from the fact that people with a defective gene for the LDL - receptor get heart disease very early — in infancy in the most extreme case — and people with a
defective gene for an enzyme that degrades the LDL - receptor have virtual immunity to heart disease.
The animals lack
the gene for an enzyme called inositol hexakisphosphate kinase 1 (IP6K1), which is known to play a role in fat accumulation and insulin sensitivity.
A gene for the enzyme that splits starch into simpler sugars has replicated itself in the dog genome, and become more efficient — a sure sign that it is in demand.
Another research group had shown that an enzyme called salt - inducible kinase inhibits melanin production in mice and that animals lacking
the gene for this enzyme developed darkened fur.
Guided by specially tailored RNA molecules,
the gene for the enzyme can be inserted anywhere on the chromosomes, and it delivers an attached transgene to the site, like a locomotive pulling a freight car.
«However, recent work has shown that at least some of the fungal partners in arbuscular mycorrhizal symbioses lack
the genes for enzymes involved in the major pathway of lipid biosynthesis, and are therefore unable to produce certain essential fatty acids,» Gutjahr explains.
Guengerich and his colleagues are planning to transfer
the gene for the enzyme into roses and then expose the plants to a chemical that would activate the blueing process.
Last year, scientists found mutated forms of
the gene for an enzyme called superoxide dismutase in people with motor neurone disease.
This is because
their gene for the enzyme lactase, which breaks lactose down, is switched off by late adolescence.
The researchers introduced yet
another gene for an enzyme used by many bacteria to make polyhydroxyalkanoates (PHAs), which are polyesters used to store carbon and energy.
But just where
the genes for these enzymes came from has been a mystery.
Its sequence resembled
a gene for an enzyme called Complex II, which helps mitochondria consume energy in cows and humans.
On Nov. 10 in the journal Science Signaling, Ferkey and Yu's team will report that the mutant worms they were studying had altered dopamine signaling because the animals were missing
the gene for an enzyme called PRMT - 5, which facilitates another important cellular process — protein arginine methylation.
Because of defects in
the gene for the enzyme, fat clogs up blood vessels in the gut and pancreas of those with LPLD.
When the researchers determined which genes were active in plants that were making lignin, they noticed one that hadn't been identified as central to lignin biosynthesis,
a gene for an enzyme called caffeoyl shikimate esterase (CSE).
Lippman and Cora MacAlister, Ph.D., lead author on the new paper, found that deleting
the genes for these enzymes from the flowering mustard plant Arabidopsis thaliana and the moss Physcomitrella patens resulted in similar defects in both species, which are widely separated in evolutionary time.
It is hard to imagine any way in which a herbicide could have identical toxic effects to a gene tweak that gives the maize
a gene for an enzyme that actually destroys the herbicide.
Researchers long have believed that to accomplish this feat, RNA viruses had to carry
the gene for an enzyme, reverse transcriptase, to convert their RNA into DNA.
They then identified a novel enzyme at work in A. annua that completes the artemisinic acid synthesis and popped
the gene for the enzyme into their yeast.
Hunter syndrome results from a mutation in
a gene for an enzyme that cells need to break down certain sugars.
Other genetic diseases include Tay - Sachs disease (damage to
the gene for the enzyme hexosaminidase A leads to an accumulation of a chemical in the brain that destroys it), sickle cell anemia (improper coding of the gene that produces hemoglobin), hemophilia (lack of a gene for a blood - clotting factor) and muscular dystrophy (caused by a defective gene on the X chromosome).
Individuals inherit two copies (one from each parent) of
the gene for the enzyme catecho - O - methyltransferase (COMT), which chemically breaks down dopamine.
Researchers found deleting
the genes for enzymes in two plants widely separated in evolutionary time resulted in similar defects...