Individuals with GSDIa have a defective
gene for the enzyme glucose -6-phosphatase, resulting in the inability to regulate blood sugar (glucose).
DTX 401 is designed to address the defective
gene for the enzyme glucose -6-phosphatase-α, a defect that results in the inability to regulate blood sugar (glucose).
Not exact matches
Hypoxia - inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression of various
genes for glucose metabolism under conditions of low oxygen levels, is the most well documented substrate of the von Hippel - Lindau (VHL)
enzyme.
This
gene gives instructions
for an
enzyme that attaches the appendage to the
glucose chain after it's produced, altering the cellulose just before it leaves the cell.
Livers collected from CA33 - treated B6 DIO mice revealed decreases in mRNA and
enzyme activity
for the gluconeogenic
genes phosphoenolpyruvate carboxykinase 1 (Pck1) and
glucose 6 - phosphatase (G6Pase).