Not exact matches
So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three
genes to
find out if an extra copy gave them extra protection
against cancer.
If similar
genes are
found in people, drugs that mimic their protective effects could be a better strategy
against cancer and ageing than simply mopping up all free radicals (PLoS Genetics, DOI: 10.1371 / journal.pgen.1000488).
In his «lessons learned» article, Wilson advises researchers
against putting themselves in situations that might create potential financial conflicts (in 1992 Wilson had
founded a biotechnology company focused on
gene therapy).
She harbors two mutant copies of a
gene, and therefore lacks a protein that manages blood clotting, but researchers
found that people with one inactivated
gene copy outlive their peers by a decade and gain protection
against diabetes.
The population study
findings, including those from the JACC study, suggest that even the partial inactivation of ANGPTL3 — carriers typically have one mutant copy of the
gene and one working copy — may be powerfully protective
against coronary artery disease, which has long been one of the leading causes of death in developed countries.
New research presented here yesterday at the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW)
finds that a
gene associated with increased risk of asthma is also linked to resistance
against a parasitic worm.
«
Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research
found many targeted therapies for prostate cancer may not be effective
against tumors in African - American men.»
To win the war
against antibiotic resistant super bugs, scientists seek to
find the origin of resistance
genes.
Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers
found that one genetic variant in the TYK2
gene protects
against a wide range of...
Additionally, when the researchers checked their network
against the DNA of patients with nonsyndromic, or «stand - alone,» autism, they
found abnormalities involving three of the network
genes.
Nine groups of bacterial
genes turned out to be antiphage defense systems, and one system protected
against plasmids, another source of foreign DNA, the researchers
found.
They may have lacked a
gene mutation that modern humans carry that offers some protection
against cancer - causing chemicals
found in wood smoke.
Intriguingly, Dr Fieten and colleagues also
found that mutation of a second copper transporter
gene, ATP7A, protected dogs
against hepatic copper accumulation.
After clearing the samples of variance due to technical artifacts that could potentially confound the
findings, they performed 3.5 trillion statistical tests
against every mutation in the genome compared to every expressed
gene in each of the 44 tissues.
When the team compared E. rubrum's
gene families
against those in two other halophilic species (Wallemia ichthyophaga and Hortaea werneckii), they
found that high acidic residues were common in all three species, a general trait all salt - tolerant microbes share.
«We
found polyploidy in liver cells did not strongly affect the activity of some oncogenes, but it did protect
against the loss of tumor suppressor
genes.
I
found that negative selection
against new mutations and positive selection for new mutations shape broad patterns of genomic variation and that much of the genomic variation that actually affects
gene expression is under negative selection.
We
found that degradation of DNA in the cytoplasm serves as one important defense mechanism
against exogenous
gene expression, and blocks the effective expression of exogenous
genes.
They
found that the transplanted cells strongly activate
genes that help to guard
against damage from ER stress, and suppress other
genes that may trigger cellular attempts to self - destruct.
Researchers have also
found the
gene that underlie the altered metabolism that protects
against arsenic.
We
found that the robustness of the
gene networks of the early organogenesis stage
against mutational changes is surprisingly low.
Upon filtering the list of 348
genes against lists of target
genes derived from whole - genome analysis studies of Oct4 binding [6], [28], 30 PORE
genes were
found to be bona fide Oct4 targets (Table S2).
The
finding that sexual isolation may be brought about by changes in at most a few
genes argues
against the evolution of new species in this manner by long - term runaway processes, as dictated by evolutionary dogma, Coyne said.
«It is certainly an interesting study, as its
findings inform us of the protective effects of the
gene associated with higher aerobic capacity
against breast cancer,» she explains.