Sentences with phrase «gene function across»
Graber will also lead the development of the Comparative Models of Regeneration Database (RegenDB), a novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug therapies.
https://mdibl.org/
Ongoing comparative analysis will provide insights to help us understand gene function across all large animal species, including humans.»
Not exact matches
Published in GigaScience, the open source Galaxy workflow allows researchers to make easier work of finding gene families; an important tool when it comes to analysing the evolution, structure and function of genes across species.
«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»
The European Mouse Disease Clinic (EUMODIC) brought together scientists from across Europe to investigate the functions of 320 genes in mice.
In search of clues about the function of the two paralogs, the researchers looked for the genes across many water strider species.
In separate experiments, they picked 13 other codons and substituted them for alternatives with the same function across 42 different E. coli genes.
A DNA sequence that is conserved across species suggests that it plays an important role in the ultimate function of that particular gene.
The interplay between fly and microbes has come to fascinate evolutionary biologists, as genes in both bacterium and host change across generations, sometimes breaking down or taking on odd functions, depending on what the other partner is doing.
They also found that these culprit genes are involved in various key human neurological functions within the prefrontal cortex, including the transmission of the neurotransmitter GABA across a synapse from one neuron to another.
The function of myostatin appears to have been conserved across species, as inactivating mutations in the myostatin gene have been demonstrated to cause increased muscling in cattle [8]--[11], sheep [12], dogs [13] and humans [14].
Researchers make knockout mice by disrupting the function of individual genes across the animal's genome.
Scientists believe that «conserved» genes — those found in life forms that range from bacteria to plants, insects and humans — perform vital biological functions across species.
A broad range of biological processes, molecular functions, cell cycle pathways (Supplementary Table S5) and gene sets from the MSigDB (Supplementary Table S6) was enriched across these different modules.
As those genes seem to be conserved across evolutionary time, it is unlikely that they are extracellular (where they would be under immune pressure), rather they must have more conserved core functions.
Importantly, unlike many connections seen in classic loss - of - function studies, the gene - gene and gene - phenotype links identified in population studies were robust and translated well across populations and species.
While not all genes with an immune function will necessarily be regulated by any specific infection, and thus an RNA - seq - based catalog of immune - related genes can not be expected to be complete, it has the significant advantage of being unbiased by assumptions about conservation of genes across species, and thus serves as a valuable starting point for comparative analysis of the evolution of immune pathways.
The focus of Dr. Smoller's research interests has been 1) understanding the genetic and environmental determinants of psychiatric disorders across the lifespan; 2) integrating genomics and neuroscience to unravel how genes affect brain structure and function; and 3) using «big data», including electronic health records and genomics, to advance precision medicine.
While it remains to be seen if Boule homologs are restricted only to spermatogenesis or also function in the ovary, we have shown a clear case of conservation of a reproduction - specific gene across Bilateria.
To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.
Signed networks were constructed in WGCNA using an adjacency function that incorporates gene correlation and connectivity across the dataset.
Intriguingly, an identical homozygous mutation was identified in a human patient with recessive retinitis pigmentosa, the human equivalent of PRA, and established the novel retinal gene, PRCD, as an important gene for the maintenance of rod photoreceptor structure and function across species.