Sentences with phrase «gene function in»

Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans.

We conclude that CRISPR - Cas9 - mediated genome editing is a powerful method for investigating gene function in the context of human development.

He continues to study cancer gene function in his Georgetown lab, and has recently identified a new cancer gene called STAG2 that is among the most commonly mutated genes in cancer, involved in causing bladder cancer, pediatric bone tumors, leukemias, brain tumors, and other tumor types.

«Studying gene function in cancer cells is now a lot more straightforward and will continue to get easier as even newer technologies are developed,» says Waldman.

Live at IMG Marie - Christine Birling, PHENOMIN - ICS, France Title: «Genome editing using nucleases: new possibilities and application to reveal gene function in diseases»

In addition, with the advancement of genetic techniques it has become an excellent model to study the gene function in vivo.

The CNCR focuses on the mechanistic understanding of gene function in the context of cognitive function.

The Phenotyping department provides comprehensive, standardized or advanced, customized characterization of gene function in mouse models.

Due to the manual curation, 12 % more genes have been assigned a gene function in the new assembly.

These projects explore the consequences of genome variation on human cell biology, and thus gene function in health and disease.

Abnormalities in mitochondrial genes, gene expression and gene function in inherited and complex diseases, like neuromuscular disorders, neurological syndromes and cardiomyopathies, in human patients and animal models, but alos in therapy - predictions (radiotherapy).

This is the first time that genome editing has been used to study gene function in human embryos, which could help scientists to better understand the biology of our early development.

INFRAFRONTIER - I3 General Meeting will be hold in Marseille, on December 9th - 10th INFRAFRONTIER aims to build a world - class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function in human disease.

«This is a great tool to study gene function in a single cell,» he says.

After decades of extrapolating about gene function in trees based on gene function in a tiny, less complex plant, a team of scientists has sequenced whole genomes — determined the DNA sequence of all the genes — from 544 unrelated trees of the same species.

RNA interference (RNAi), an effective tool to assess gene function in many organisms, is largely ineffective in apicomplexans, while random mutagenesis is difficult to interpret because the altered gene is difficult to identify.

This would allow them to better understand gene function in a variety of neurological disorders.

The light - activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

«While they're useful for studying gene function in an animal, they also have their own inherent interest,» Melton says.

The article published on the journal Molecular Biology and Evolution provides the framework for posing new hypotheses on the phylogenetic relations among poriferans, determining gene function in sponges and the early evolution of molecular complexity in metazoans.

They validated the cell models and showed that changing clock gene function in these cells is similar to what happens in mice lacking clock genes.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

With molecular biologist Gregory Hannon of Cold Spring Harbor Laboratory in New York state, Elledge developed genetic tools that examine how genes function in human cancer cells.

Both genes function in the homologous recombination (HR) pathway of the DNA double - strand break (DSB) repair...

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such as cancer.

The frog genes functioned in their new home.

Large - scale targeted - deletions have been successful in defining gene functions in the single - celled yeast Saccharomyces cerevisiae, but comparable analyses have yet to be performed in an animal.

Not exact matches

The advance is based on a technique that allows scientists to narrow in on a specific gene and cut - and - paste bits of DNA to change its function, known as CRISPR - Cas9.

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

Our genome is nearly identical to the chimpanzee genome, a little less identical to the gorilla genome, a little less identical to the orangutan genome, and so on — and this correspondence is present in ways that are not needed for function (such as the location of shared genetic defects, the order of genes on chromosomes, and on and on).

Gene Reeves, however, has contested Cobb's conclusion.93 Reeves argues in detail that Cobb's theory of the originative function of the initial aim can not be sustained.

The original change is reversed by mutations occurring at high frequency, not just reversing the engineered change — that does happen, to be sure — but causing compensatory changes that appear in many places in the knocked out gene restoring function to the gene in quite unexpected ways.

In other words, they now have total control over that genome and can examine the function of every gene, seeing if each part of the genome serves a biological function or is redundant.

What all these have in common is that, without any central control, individual units (genes, cells neurons or workers) respond to simple, local information, in ways that allow the whole system (cells, brains, organisms or colonies) to function: the appropriate number of units performs each activity at the appropriate time.

The EC has historically supported IRRI's work to conserve the genetic diversity of rice, understand the function of rice genes, and develop new rice varieties, particularly for use in difficult growing environments.

This can disrupt the functioning of other genes and create novel proteins that have never been in the food supply and could create toxins and allergens in foods.

A gene on the Y chromosome becomes active late in the sixth week, functioning for only a few days to tell the embryo to become a boy.

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

Blasting GM DNA into a plant arbitrarily and out of a sequence of genes that has evolved over hundreds of millions of years, in a manner aimed to optimise the functioning of an organism, is risky and unpredictable, and bound to destabilise the biochemistry of the plant.

The acetylation changes were observed at genes that mediate glutamatergic function, specifically the glutamate receptor gene GRIA1, which has previously been implicated in drug use.

The team cemented its finding by noting the mice's neurons» ability to undergo long - term potentiation — a type of response to stimulation, which has been implicated in learning processes — after gene function was restored.

The scientists from the Montreal Neurological Institute and Hospital at McGill University, led by Peter McPherson, along with collaborators in Saudi Arabia, Jordan, Germany, and at SickKids Hospital and the University of Toronto, have discovered that a severe form of epileptic encephalopathy is caused by recessive loss - of - function mutations in the gene DENND5A.

When the authors tested the ability of the lizard and snake versions of this limb - genital enhancer to function in mice, they found that the lizard version was capable of driving gene expression in the legs and the genitalia (much like the mouse version), while the snake version was only capable of driving gene expression in the genitalia.

An international team of experts developed an injection that restored the function of dystophin - expressing genes in 12 golden retrievers.

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

A large number of genes involved in nervous system development and function were also deregulated.