It is used today primarily
by gene hunters and other researchers who focus on specific areas of the genome.
For gene hunters, it's relatively straightforward to determine where a version of a particular gene lies on a given chromosome.
Stefánsson is the famous
gene hunter who spearheaded the effort that mapped 65 percent of Iceland's genome.
The map
allows gene hunters to get away with less (and thus cheaper) DNA sequencing while still, it's hoped, homing in on disease genes.
With increased access to information and off - the - shelf supplies, the practice of bioscience is becoming available to a burgeoning community that
includes gene hunters, curious tinkerers, and independent bioengineers eager to try their hand at creating synthetic life.
While the Perlegen HapMap differs somewhat from the HapMap created by the international consortium map, says Cox, both should
point gene hunters to similar DNA regions — though that hasn't been put to a rigorous test.
Gene hunters still need physical maps, with their cloned fragments of DNA that correspond to specific portions of chromosomes.
The second and third articles
follow gene hunters into more isolated and homogeneous gatherings of people — the Finns at the top of the European continent and the Native Americans in Arizona and New Mexico.
By bringing together seemingly disparate disciplines, bioinformatics has united the foot soldiers of scientific research: Computer scientists find themselves sharing coffee
with gene hunters, programmers sit in on molecular biology seminars, and biologists and technologists share bylines on research papers.
Although Jack and Malcolm had never met F2F, they were a tight team with a good rep on the Distributed Biology Network:
gene hunters who amplified bacterial DNA from soil and water samples, shotgun sequenced it, and identified genes that weren't in the catalogs.
In the coming months, plummeting costs will
allow gene hunters to start routinely working with complete human genome sequences.
«It's my life's work to solve the problem of heart disease,» said Jukka Salonen, an epidemiologist and
gene hunter at the University of Kuopio.
Gene hunters have had an outstanding year, bagging genes for Huntington's disease, Alzheimer's, amyotrophic lateral sclerosis and many other hereditary illnesses.
After crudely mapping a gene to within a few million base pairs of a chromosomal marker,
gene hunters could sequence the entire region in a bid to find it.
Herbert argues that «we can address the disturbed pathways now, before
the gene hunters have definitive information.
When it comes to questions of human behavior, Dean Hamer, big -
gene hunter, is sure he's got the answers.
This is absolutely necessary: just ask
any gene hunter to tell you about that huge linkage peak they have in a region without any annotated genes.
This will require bringing together the functional experts (molecular biology, model organisms, and reverse genetics) with the «
gene hunters» as well as a serious commitment from funding agencies.
This unique research model was first established and proven in 1983 when the HDF brought together a multi-disciplinary group of about 100 international scientists, know now as «
The Gene Hunters,» to discover the Huntington's disease gene.