Sentences with phrase «gene in embryonic development»

A new study indicates an essential role for a maternally inherited gene in embryonic development.

Not exact matches

From such work, we've learned that many of the genes deployed in the developing phallus are also used to build limbs during embryonic development.

The huntingtin gene is essential for embryonic development, and scientists have already shown that if mouse embryos don't have it at conception, they die in utero.

The researchers discovered that both major living lineages of birds (the common neognaths and the rarer paleognaths) differ from the major lineages of non-bird reptiles (crocodiles, turtles, and lizards) and from mammals in having a unique, median gene expression zone of two different facial development genes early in embryonic development.

Furthermore, p53 inhibition could be harmful because this gene has many functions in correct embryonic development,» they add.

You can't necessarily see the change happening in the adult, but you can see that if you change that nucleic acid base right there in that gene, at that particular point in embryonic development, that animal is darker.

The ALK gene is important during embryonic development of the nervous system but should be inactive later in life.

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

Those deletions tended to involve genes that affect cilia, cellular structures that are important for signaling and patterning in embryonic development.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

According to a report published online today by the journal Nature, mutations in genes that guide embryonic development allowed insects to develop a radically different body plan from that of their crustacean - like ancestors some 400 million years ago.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

This program normally shuts off after embryonic development, but occasionally — for reasons not yet known — crestin and other genes in the program turn back on in certain cells.

In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.

They hope to study APOBEC's importance in fighting off mutations early in the development of embryonic life, and in the development of the eggs and sperm that carry our genes to the next generation.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

The findings are reported in the article «A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential» published online December 15 in Genes & Development.

Embryonic development is a well - studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner.

The «Hox» genes, involved in embryonic development in all animals, are a particularly dramatic example.

Using the CAGE (Cap Analysis of Gene Expression) high - throughput method, the scientists determined the starting points of transcription of many thousands of genes in various phases of embryonic development of zebrafish.

The gene's apparently crucial role in embryonic development «is remarkable,» says William Kimberling, a geneticist at Creighton Medical School in Omaha, Nebraska, who studies children with BOR.

In addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such as Keratin - related gene families associated with hair formation, several Hox genes that play an important role in the body plan and embryonic developmenIn addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such as Keratin - related gene families associated with hair formation, several Hox genes that play an important role in the body plan and embryonic developmenin the body plan and embryonic development.

The next step, he says, is to investigate how embryonic mouse brains with induced folds develop as they mature past the fetal stages of development and to look across species to see if the gene has similar effects in other mammals.

Seeking fresh sources, they looked for cells that express the gene neurogenin 3, a potential sign of cell differentiation because it is the first gene to only switch on in pancreatic islets during embryonic development.

Now, with more ways to monitor gene activity during development — and fully sequenced genomes of various snakes and other reptiles for comparison — Cohn and graduate student Francisca Leal have tracked the genetic activity in embryonic pythons to see why their legs start, but never finish, developing.

Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.

To find out what these genes do, and which ones are master regulators of development, researchers have several approaches, including deactivating embryonic genes in mice.

As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.

Cook's illustrious subjects include the umbrella - bearing British cosmologist Sir Martin Rees of the University of Cambridge, the wrinkle - faced late naturalist and flea expert Miriam Rothschild, and the biologist Christiane Nüsslein - Volhard (left) of the Max Planck Institute for Developmental Biology in Tübingen, Germany, who won the 1995 Nobel Prize in Physiology or Medicine for codiscovering key genes that shape embryonic development.

The researchers used this live - imaging technique to study fly embryos at a key stage in their development, approximately two hours after the onset of embryonic life where the genes undergo fast and furious transcription for about one hour.

However, malformation of skeletal bones during embryogenesis also occurs in FOP patients and illustrates that the underlying genetic mutation occurs in a gene with functional importance in regulating chondro - osseous differentiation during embryonic skeletal development as well as in adult musculoskeletal tissues.

«New methods such the CRISPR - Cas9 system for gene editing now make it possible to carry out functional studies in other species, and this will in turn lead to decisive advances in our understanding of early embryonic development in mammals.»

Researchers have identified genes that play a role in the condition, some of which are essential for cerebral cortex growth during embryonic development.

Christiane Nüsslein - Volhard and Erich Wieschaus were awarded the Nobel Prize in Medicine in 1995, for the first systematic genetic analysis of embryonic development in the fruit fly, in which they identified genes responsible for the body plan of insect embryos.

In the new research, Pollen and co-first author Tomasz Nowakowski, PhD, also a postdoctoral researcher in the Kriegstein lab, partnered with Fluidigm Corp. to develop a microfluidic approach to map out the transcriptional profile — the set of genes that are actively producing RNA — of cells collected from the VZ and SVZ during embryonic developmenIn the new research, Pollen and co-first author Tomasz Nowakowski, PhD, also a postdoctoral researcher in the Kriegstein lab, partnered with Fluidigm Corp. to develop a microfluidic approach to map out the transcriptional profile — the set of genes that are actively producing RNA — of cells collected from the VZ and SVZ during embryonic developmenin the Kriegstein lab, partnered with Fluidigm Corp. to develop a microfluidic approach to map out the transcriptional profile — the set of genes that are actively producing RNA — of cells collected from the VZ and SVZ during embryonic development.

Zebrafish also express this gene, and the study showed that it plays a crucial role in embryonic development.

The gene, known as gata5, acts in embryonic cells, which are primordial, unspecialized cells that form in the earliest stage of embryonic development and are genetically programmed to evolve into one of many specialized cell types, such as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

«Discovery of a gene that could convert human embryonic stem cells into myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF study and a pioneer in the study of heart development in the transparent zebrafish embryo.

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

They found that groups of genes appear to work together in heart cells in a coordinated fashion — switching on and off as a group at designated times during embryonic development.

In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned oIn this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned oin order to determine how the Dll4 gene is turned on.

Eight HARs showed differences in their enhancer activity when the human mutations were present.4 These differences modify how genes were expressed in the developing limb (HAR2, 2xHAR114), eye (HAR25), and central nervous system (2xHAR142, 2xHAR238, 2xHAR164, 2xHAR170, ANC516 / HARE5).4, 10 Because relatively few time points have been examined, it is likely that an even higher percentage of the tested HARs are active enhancers at some point during embryonic development or in adult tissues, possibly with human - chimp differences.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

Lanner is attempting to edit genes in human embryos to learn more about how the genes regulate early embryonic development.

Created in 2005 through a collaboration between Inserm — National Institute of Health and Medical Research — and AFM - Telethon — French Association against Myopathies — I - Stem is the largest French laboratory for research and development dedicated to human pluripotent stem cells, of embryonic origin or obtained by reprogramming gene.

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

These findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres.

Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.