Researchers have used genome editing technology to reveal the role of a key
gene in human embryos in the first few days of development.
Sarah Norcross, Director of the Progress Educational Trust, said: «The UK has pioneered embryo research and while UK - based scientists need to keep a close watch on developments in China and elsewhere, public discussion of the ethics and implications for society of
editing genes in human embryos needs to be stepped up so that policymakers can make informed decisions about whether the law should be changed in the UK to permit this type of research.»
And in a milestone this year, Oregon Health and Science University researchers used CRISPR to successfully correct heart disease -
causing genes in human embryos.
The first UK license for CRISPR / Cas9 use in
editing genes in human embryos was granted in 2016, xvii and CRISPR - edited cells to treat lung cancer were administered in the world's first human trials for the technique by a Chinese group in late 2016.
In April 2015, researchers in China reported that they had used CRISPR, with limited success, to repair a disease -
causing gene in human embryos.
But organizers of the International Summit on Human Gene Editing said editing
genes in human embryos was permissible for research purposes, so long as the modified cells would not be implanted to establish a pregnancy.
For the first time, researchers have disabled
a gene in human embryos to learn about its function.
Chinese researchers have twice reported editing
genes in human embryos that are unable to develop into a baby (SN Online: 4/6/16; SN Online: 4/23/15).
At the Karolinska Institute in Stockholm, Fredrik Lanner is preparing to edit
genes in human embryos.
► The potency of new gene - editing technologies presents new ethical quandaries for scientists — as demonstrated by the debate following an announcement that a Chinese team had altered
genes in a human embryo.
This concern was also brought to the forefront of the scientific and public consciousness when a report by Chinese scientists described the use of CRISPR - Cas to modify
a gene in human embryos making them resistant to HIV infection [to learn more about CRISPR - Cas, read our previous blog].
Lanner is attempting to edit
genes in human embryos to learn more about how the genes regulate early embryonic development.
But there are already reports that Huang's group and possibly others in China continue to try editing
the genes in human embryos.