Sentences with phrase «gene in humans leads»

Conversely, the lack of this same gene in humans leads to a developmental disorder called Angelman's syndrome, characterized by increased sociability.

Not exact matches

It is for this reason that utopian thinking led some of its modern promoters, such as Arthur Koestler and Carl Sagan, to propose ways of «improving» human beings by biological manipulation such as surgical removal of certain centers in the brain or by genetic engineering to remove «bad» genes.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

Diane Dickel is the lead author of Nature Methods paper describing a new technique for identifying gene enhancers in the genomes of humans and other mammals.

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

In one experiment with human cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

Matthew Brown, a skeletal geneticist at the University of Oxford says the gene is «a really hot candidate for [human] chondrocalcinosis,» a rare genetic form of joint stiffening that leads to crystal deposition and shows a similarly imbalanced pyrophosphate distribution in the joints.

To test this hypothesis, an international team led by evolutionary biologist Philipp Khaitovich of the Shanghai Institutes for Biological Sciences in China and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, set out to see how many brain - related genes implicated in schizophrenia underwent positive natural selection since humans and chimpanzees diverged from a common ancestor between 5 million and 7 million years ago.

A team of scientists, led by academics from King's College London and Erasmus MC University Medical Center Rotterdam, have discovered 124 genes that play a major role in determining human hair colour variation.

Joint lead author Professor Manfred Kayser from Erasmus MC said: «Besides substantially increasing our understanding of human pigmentation genetics in general, finding these new hair colour genes is also important for further increasing the accuracy of hair colour prediction from DNA traces in future forensic applications, which can help to find unknown perpetrators of crime.»

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

The method, reported in the November issue of Nature Biotechnology, could lead to safe and effective human gene therapies for cystic fibrosis, hemophilia, and a variety of other diseases.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druIn one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druin Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druin groups of cells to identify those involved in resistance to a melanoma druin resistance to a melanoma drug.

For the first time, a research team led by Dr. Ralf Gilsbach and Prof. Dr. Lutz Hein from the Institute of Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg have mapped out the gene regulators in the DNA of human cardiac muscle cells.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

To do so, a team led by neuroscientist David Holtzman of Washington University in St. Louis injected genes for human apoE3 or apoE4, which is about a third as common, into fertilized mouse eggs.

Two studies presented at the Biology of Genomes meeting in Cold Spring Harbor, New York, last week show how human genomes have changed over centuries or decades, charting how since Roman times the British have evolved to be taller and fairer, and how just in the last generation a gene that favors cigarette smoking led to early death in some groups.

However, since the novel genes that were identified, are known to lead to aging - associated diseases in humans, their further analysis seems to be promising for developing new approaches to understand and possibly cure these diseases and to contribute to a long life and healthy aging in humans — in a way, long - lived rodents do.

Alongside its soon - to - be — unveiled physical map, CEPH - Genethon is also leading the world with its efforts to build human «genetic maps» — maps which show the relative positions of thousands of genes, culled from careful genealogical work on the way characteristics are passed on in human families.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

And researchers at the «Seattle project», an effort funded by the National Cancer Institute to find new anticancer drugs, are mutating genes in yeast cells — such as the ATM gene or the mismatch repair genes — that often lead to cancer in humans.

In the study, the working group led by Leopold Eckhart investigated the genes responsible for the skin layers of the shell of the European terrapin and a North American species of turtle, in order to compare them with the genes of human skiIn the study, the working group led by Leopold Eckhart investigated the genes responsible for the skin layers of the shell of the European terrapin and a North American species of turtle, in order to compare them with the genes of human skiin order to compare them with the genes of human skin.

Mutations in the human gene encoding the Nav1.7 sodium channel can lead to either the inability to sense pain or pain hypersensitivity.

Geneticists speak of «mapping» the human genome, so that we know where genes «for» all kinds of things (from homosexuality to manic depression) are located; a promotional video produced by the Human Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found&rahuman genome, so that we know where genes «for» all kinds of things (from homosexuality to manic depression) are located; a promotional video produced by the Human Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found&raHuman Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found».

In the animal studies, mice containing the gene expressing human resistin and infected with a parasitic worm similar to the human hookworm experienced excessive inflammation, leading to increased weight loss and other symptoms.

The book, A Troublesome Inheritance: Genes, Race and Human History, contends that human races are a biological reality and that recent human evolution has led to racial differences in economic and social behaHuman History, contends that human races are a biological reality and that recent human evolution has led to racial differences in economic and social behahuman races are a biological reality and that recent human evolution has led to racial differences in economic and social behahuman evolution has led to racial differences in economic and social behavior.

«Fish eyes to help understand human inherited blindness: Discovery of a gene in zebrafish that triggers congenital blindness could lead to a suitable cure for similar disease in humans..»

Deth reported last year, for example, that in human nerve cells thimerosal blocks a chemical reaction called methylation that is critical to gene activity and that is also disabled by exposure to lead.

In previous research, Quaggin's lab showed that deleting the gene in mouse models led to glaucoma, but the scientists didn't know how mutations impairing the gene affected humanIn previous research, Quaggin's lab showed that deleting the gene in mouse models led to glaucoma, but the scientists didn't know how mutations impairing the gene affected humanin mouse models led to glaucoma, but the scientists didn't know how mutations impairing the gene affected humans.

In the first study, published in Science (25 April 2003, p. 640), a team led by John Collinge of University College London (UCL), looked at a human gene called PRNP which codes for prions (ScienceNOW, 10 April 2003In the first study, published in Science (25 April 2003, p. 640), a team led by John Collinge of University College London (UCL), looked at a human gene called PRNP which codes for prions (ScienceNOW, 10 April 2003in Science (25 April 2003, p. 640), a team led by John Collinge of University College London (UCL), looked at a human gene called PRNP which codes for prions (ScienceNOW, 10 April 2003).

Led by scientists at The Institute for Genomic Research (TIGR) in Rockville, Maryland, and the Wellcome Trust Sanger Institute in the United Kingdom, the study indicates that the amoeba has snagged an astonishing 92 genes from bacteria in recent times, presumably by gobbling them up during its life in the human gut.

The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene - and stem cell - based therapies, said Keith Latham, MSU animal science professor and lead author of the study.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

To nail down these evasive genes, teams led by human geneticist Jonathan Haines of Vanderbilt University in Nashville, Tennessee, and neurologist Jan Hillert of the Karolinska Institute in Stockholm, Sweden, compared several thousand MS patients from the United States and Europe with their family members and healthy controls.

For their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.

There are something like 60,000 genes in the human genome, and over 5,000 of them, if damaged or missing, are known to lead to genetic diseases.

Our work has implications for two human genetic diseases, which are caused by mutations in the ATP7B and ATP7A genes and lead to copper overload in the liver (Wilson Disease), due to the failure to excrete copper into the bile, and copper deficiency in many organs (Menkes Disease), due to the failure to deliver intestinal copper to the blood.

One CUMC team, led by Tom Maniatis, PhD, the Isidore S. Edelman Professor and chair of biochemistry & molecular biophysics, will construct an atlas of gene activity of all cells in the human spinal cord.

The National Human Genome Research Institute, part of the National Institutes of Health, has awarded $ 9.1 million over four years to a research team led by the University of Chicago to identify all regulatory elements, the DNA sequences that control when and where specific genes get turned on or off, in the fruit fly genome.

We now understand the chain of action: how our genes shape this function in our brains and how that, in turn, leads to human behaviour.

The 2013 Warren Alpert Foundation Prize will be awarded to David Botstein of Princeton University, and Ronald W. Davis and David S. Hogness, of Stanford University School of Medicine, for their seminal contributions to the concepts and methods of creating a genetic map in the human, leading to the identification of thousands of disease genes.

Inhibitors and activators of fusion, members of various signaling pathways, genes that when mutated, lead to muscle dystrophies in human: there are many surprises within this list of putative modulators of muscle fusion.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

The gene and associated mechanism of quality control appears to be conserved in mammals, but there is as yet little further research leading towards trying a similar approach in mice and humans to see what happens.