However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer
gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.
Not exact matches
When the group
stopped the
gene working
in mice, the animals no longer developed diabetes if fed a high - fat diet.
When researchers suppressed the ARF
gene in mole - rat cells during the reprogramming process to iPSCs, the cells
stopped proliferation with sign of cellular senescence, while the opposite happens with
mouse cells.
Instead, they found,
in quiescent satellite cells taken from the younger
mice, copious instances
in which histones
in the vicinity of
genes ordinarily reserved for other tissues were marked with both «
stop» and «go» signals, just as
genes associated with development to mature - muscle status were.
When bred to
mice with a cre recombinase
gene under the control of a promoter of interest, the
STOP sequence of the targeted
gene is deleted
in the tissue of interest, and EYFP expression is observed.