Sentences with phrase «gene in the yeast cell»

Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.

And researchers at the «Seattle project», an effort funded by the National Cancer Institute to find new anticancer drugs, are mutating genes in yeast cells — such as the ATM gene or the mismatch repair genes — that often lead to cancer in humans.

Not exact matches

Yoshinori Ohsumi, the most recent prizewinner, used baker's yeast to identify genes crucial in autophagy, the process by which cells recycle their components.

The new compounds boost the activity of Sir2 in yeast and of an analogous gene, SIRT1, in human cells.

A class of small molecules found in grapes, red wine, olive oil, and other foods extends the life of yeast cells by approximately 70 % and activates genes known to extend life span in laboratory animals.

To answer this question, the researchers created numerous premature stop signs, known as nonsense mutations, in test genes in human and yeast cells.

Already, researchers have used CRISPR / Cas9 to edit genes in human cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.

She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the cell - cycle regulated HO gene in the yeast Saccharomyces cerevisiae.

They found numerous genes activated in the XYL regulon - controlled yeast that upregulated pathways involved in growth, such as cell wall maintenance, cell division, mitochondrial biogenesis and adenosine triphosphate (ATP) production.

When Fishel and Kolodner heard of the accumulation of mutations in cancer cells from patients with familial colon cancer, they suspected that the gene responsible would be similar to the bacterial and yeast genes they had studied.

Dr Nadeau added «Our results are even more surprising because the cortex gene was previously thought to only be involved in producing egg cells in female insects, and is very similar to a gene that controls cell division in everything from yeast to humans.»

But while this study has proved that the technique works in a simple organism, it could also be applied to other bacterial species, yeast or even human cells to find useful information about how genes are controlled and how they can be manipulated.

A yeast retrotransposon called Ty3, the researchers have found, is especially judicious: it always inserts itself in safe places, outside genes rather than inside them, and only near genes of which a yeast cell has many copies.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

«Mapping the genes that increase lifespan: Comprehensive study finds 238 genes that affect aging in yeast cells.»

Light played a key role in the experiment because it allowed the researchers to switch on genes that they had added to the yeast cells.

If the cells grew on culture plates, the team inferred that the human gene could fill in for its yeast equivalent.

In 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquIn 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin aging.»

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

The group took the first step toward their goal of a novel engineering strategy for yeast by creating what is known as a cDNA library: a collection of over 90 % of the genes from the genome of baker's yeast (Saccharomyces cerevisiae), arranged within a custom segment of DNA so that each gene will be, in one version, overactive within a yeast cell, and in a second version, reduced in activity.

An ambitious study in yeast shows that the health of cells depends on the highly intertwined effects of many genes, few of which can be deleted together without consequence.

October 21, 1994 Immortalizing agent of tumor cells found in yeast Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal.

Simon's strategy is to compare the effects of a drug on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal cell division - a property that is disrupted in cancerous cells.

A dual yeast and human stem cell discovery platform for Parkinson's disease: Investigations in simple baker's yeast cells brought to light abnormalities in Parkinson's patient neurons and identified genes and small molecules that correct them.

These methods integrate single - cell experiments and discrete stochastic analysis to predict complex gene expression and signaling behaviors in Saccharomyces cerevisiae — or yeast, a scientific - lab standard since yeast and human cells share many genes.

The research team identified predictive models of transcription — the first step in gene expression — when the yeast cell is responding to osmotic stress (salt), which greatly affects cell growth.

Kennedy is interested in understanding why reduced gene expression in ribosomes enhances longevity in yeast and worms — ribosomes are tiny organelles that occur within the cell and are involved in the production of proteins.

The human microbiome — the diverse array of bacteria, yeast, parasites, and other single - celled organisms that live in and on our bodies — is comprised of more microbes than there are stars in the galaxy, and the genes encoded in microbiome DNA vastly outnumber our own genes.

Large - scale targeted - deletions have been successful in defining gene functions in the single - celled yeast Saccharomyces cerevisiae, but comparable analyses have yet to be performed in an animal.

Breeden, Prentice and Zhao, whose study appeared in the May 8 Proceedings of the National Academy of Sciences, compared their new algorithm to other methods used to analyze microarray experiments designed to identify cell cycle genes in yeast.

We combine biochemical, structural, cellular and functional information using purified proteins, mutant and transgenic plants, yeast and chemical genomic screening systems, transient gene expression assays, confocal microscopy and in silico data analysis to compare ROP - centered kinase signaling during cell polarity (in vitro pollen tubes), morphogenesis (whole plant) and pathogenesis (fungi - infected cells).

This new research, conducted by scientists in Belgium and published in the journal Nature Communications, found that in yeast, the presence of high levels of glucose (sugar) can activate a gene called Ras — the role of which is to regulate cell generation, both in mammals and in yeast — which is often found in tumours.