Sentences with phrase «gene inactivation in»

However, conditional gene inactivation in diploid cells is still difficult to achieve.

His research currently focuses on determining the mechanisms and consequences of cohesin gene inactivation in human cancer.

Not exact matches

Before the divergence, the common bacteria ancestor had undergone a massive reductive evolution that resulted in inactivation of approximately 40 percent of all the genes in its genome.

The population study findings, including those from the JACC study, suggest that even the partial inactivation of ANGPTL3 — carriers typically have one mutant copy of the gene and one working copy — may be powerfully protective against coronary artery disease, which has long been one of the leading causes of death in developed countries.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Combining this mouse model with the reliable RNA sequences allowed an efficient inactivation of genes in primary cells.

«Because TIA - 1 is known to suppress COX - 2 expression in other cells, we reasoned that the inactivation of the TIA - 1 gene would increase COX - 2 expression in neurons and, consequently, would increase resistance to acute seizures,» he continues.

«In that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane sayIn that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane sayin the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane says.

Another is involved in X chromosome inactivation, which ensures that females don't get a double dose of proteins made by genes housed on their pair of X chromosomes.

Genes in the first group were expressed in many organs; these housekeeping genes have X homologs that escape X inactivaGenes in the first group were expressed in many organs; these housekeeping genes have X homologs that escape X inactivagenes have X homologs that escape X inactivation.

The researchers were able to show that mice with an acute inactivation of the p53 gene in liver had difficulties in adapting their metabolisms to starvation.

** microRNAs (miRNAs) are noncoding RNAs which play an important role in gene regulation and in particular in the inactivation of genes.

Inactivation of this gene in zebrafish induced retinal photoreceptor defects that were rescued by human NEK2mRNA.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

Consistent with these results, genetic inactivation of an HR gene (Fancd2) and Polq in mice results in embryonic lethality.

In addition, some CFSs overlap tumor suppressor genes, whose inactivation further fuels tumor progression.

Finally, the functional inactivation of our target gene by one identified pharmaceutical agent will be tested in DM1 mouse model in order to monitor its ability to impact in vivo on DM1 molecular and physiological features.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

Inactivation of ABL kinases inhibited the expression of the TAZ target gene AXL, which shows increased expression in several human cancers and correlates with poor prognosis, increased invasiveness and metastasis, and enhanced drug resistance (53, 54).

In humans, inactivation of the TBX3 gene causes a constellation of birth defects known as Ulnar - Mammary Syndrome.

Researchers from the Institute of Psychiatry and colleagues found evidence that gene inactivation is often skewed toward one X chromosome over the other, and that this bias may already be established in early childhood.

In one of these projects, we seek to understand how inactivation of one allele of the SOX5 gene causes LAMSHF syndrome.

We found that inactivation of the ABL kinases in breast cancer cells also decreased STAT5A mRNA and downstream expression of STAT5 target genes, including TNC (Fig. 6D).

Further, inactivation of the ABL kinases resulted in decreased expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and cytokine / cytokine receptor pathway signatures (Fig. 6B).

CELPHEDIA with the partners of PHENOMIN (ICS, TAAM, CIPHE), the National Infrastructure for Mouse Phenogenomics, is committed in international consortia, such as IMPC «International Mouse Phenotyping Consortium» whose goal is to create the functional encyclopedia of the mouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functions.

ii) HNPCC: germ line inactivation of one allele of either of the mismatch repair genes MSH2 or MLH1 in combination with somatic inactivation of the other allele leads to an increase in the mutation rate, which in turn speeds up the adenoma to carcinoma progression.

The SKIP - e bioinformatics system has been developed to assist researchers in selecting antisense oligonucleotides that can be used as therapeutic agents to restore the production of a functional deleted protein such as for DMD or as tools to study gene function through the inactivation of a protein through nonsense mediated decay.

We use the Cre - loxP recombination system to generate mice with cell type - specific inactivation of the IL - 10 gene in order to identify cellular sources of the cytokine that are relevant in various situations of immune challenge.

Allele - specific expression of the MAOA gene and X chromosome inactivation in in vitro produced bovine embryos

We are currently employing our new genetic tools for mast cell - specific inactivation of loxP - flanked genes and for inducible ablation of mature mast cells in adult animals to clarify the roles mast cells play in neoplastic disease.

In cancers, aberrant promoter CpG island hypermethylation correlates highly with gene inactivation and can account for lack of gene expression where mutations do not exist.

We have generated new genetic tools for the analysis of in vivo mast cell functions that allow for cell type - specific inactivation («knock out «-RRB- of target genes selectively in mast cells by Cre loxP - mediated recombination.

Mutation in a tumor suppressor gene acts in the opposite way, causing cancer in a recessive fashion by inactivation of the tumor suppressor protein.