Sentences with phrase «gene interaction screens»

Not exact matches

The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.

use CRISPR - Cas technology to carry out genome - wide screens of gene - gene, gene - drug and cancer - microenvironment interactions in cells and mice in order to explore fundamental biology and to identify drug targets and drug resistance / sensitisation mechanisms.

Molecular and cell biology of retrovirus - host cell interactions — Development and application of retroviral gene transfer and drug screening systems

We have previously identified hundreds of new cell division genes by RNAi - based screening of the entire human genome and we are now studying — in live cells and with high - throughput — protein function, interactions and networks.

In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systems.