Sentences with phrase «gene interactions in»

Little empirical research, however, has been undertaken that examines gene × gene interactions in the etiology of conduct disorder and antisocial behavior.

In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanisms.

This highlights the importance of integrating gene — gene interactions in the genetic studies.

Evidence for a gene — gene interaction in predicting children's behavior problems: Association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7 - year - olds

Not exact matches

«The interaction of genes, environment and nurture come together in complex ways to produce the variety of human behavior.»

A separate genetics adviser will review, support and identify potential linkages in the genetics component of methane mitigation, including genomics (work on recombinant DNA and gene sequencing) and genetic interaction with environment.

Ongoing projects include studies of gene - environment interactions and adverse pregnancy outcomes, as well as informed medical decision making demonstration projects in Medicaid maternity populations and within HealthWise, the nation's largest source of health information materials distributed through healthcare networks.

We confirmed this gene — environment interaction in two birth cohorts, and we ruled out alternative explanations of the finding involving gene — exposure correlation, intrauterine growth, social class, and maternal cognitive ability, as well as maternal genotype effects on breastfeeding and breast milk.

This study found that the interaction between these genomes and the implications on energy production is strong enough that the mitochondrial genome can alter which version of a gene is present in the nuclear genome.

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

The huntingtin gene encodes a large scaffold protein, with many interaction partners, which is thought to be involved in intracellular trafficking.

After moving to Berkeley, he arrived at a career crossroads in 1994, when Spyros Artavanis - Tsakonas, then at Yale, discovered and subsequently patented the human relative of the fruit fly gene notch, which plays a role in cell - to - cell interactions and could be an anti-cancer target.

The answer is that it forms the platform for illuminating the interaction between the use of animal manure and the appearance of genes for antibiotic resistance in soil.

Using the genomic technologies he's learned at the IGB, Woolbright hopes to develop a research program that investigates climate - driven changes in species interactions at the gene level.

Previous work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different cell types are organized differently in three dimensions.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

This finding, reported in today's Proceedings of the National Academy of Sciences, is an important example of a disease caused by the interaction of two genes.

Yin is the corresponding author of a study published in the peer - reviewed academic journal Nature Communications, which shows those interactions depend on a pair of genes known as BES1 and RD26.

In doing so, they preserved a more natural interaction between the genes that govern feeding and those that govern survival.

They achieved this by transiently disturbing interactions between target genes and PcG proteins, which are complexes involved in the repression of several genes governing development.

James Collins, a professor of biomedical engineering at Boston University who was not associated with this research, says, «Efforts in synthetic biology to create complex gene circuits are often hindered by unanticipated or uncharacterized interactions between submodules of the circuits.

Studies seeking subtle signs of selection in the DNA of humans and other primates have identified dozens of genes, in particular those involved in host - pathogen interactions, reproduction, sensory systems such as olfaction and taste, and more.

In a 2006 study published in Cell, Vidal and Huda Zoghbi, a neurobiologist at Baylor College of Medicine in Houston, Texas, teamed up to show previously unsuspected interactions among the proteins produced by mutated genes in several of the movement disorders known as ataxiaIn a 2006 study published in Cell, Vidal and Huda Zoghbi, a neurobiologist at Baylor College of Medicine in Houston, Texas, teamed up to show previously unsuspected interactions among the proteins produced by mutated genes in several of the movement disorders known as ataxiain Cell, Vidal and Huda Zoghbi, a neurobiologist at Baylor College of Medicine in Houston, Texas, teamed up to show previously unsuspected interactions among the proteins produced by mutated genes in several of the movement disorders known as ataxiain Houston, Texas, teamed up to show previously unsuspected interactions among the proteins produced by mutated genes in several of the movement disorders known as ataxiain several of the movement disorders known as ataxias.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

«Our work helps us to understand what causes human diversity in appearance by showing how genes involved in pigmentation subtly adapted to external environments and even social interactions during our evolution.

TEDDY researchers next plan to look at factors including interaction between genes and the environment, including examining how diet affects bacteria in the gut and the immune system of children with differing genetic risks.

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

The researchers next conducted a variety of brain mapping experiments to locate where in the brain these crucial seizure - gene interactions take place.

«We have developed a bioinformatics approach that suggests that such changes might alternatively occur through changes in the interactions of proteins encoded by the gene.»

Even though the corn has only four leaves, the way in which its genes are expressed has already been altered through interaction with the velvetleaf planted alongside it, according to plant science professor Sharon Clay.

The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.

He found that the genes together regulate the interaction between the two mutually exclusive behaviors, sleep and feeding, kicking in to suppress sleep when a fly is hungry.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

According to a new study recently published in the online edition of the journal Cancer Research, scientists pinpointed a novel interaction between the genes AEG - 1 and Akt2 that regulates the malignant characteristics of GBM.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

«The database is a precious resource for the research community studying plant - microbe interactions as it is an unbiased way to identify potentially interesting genes involved in interaction with a plant — including many totally novel genes.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

Based on their gene - drug interaction map, the researchers predicted that mutations in two genes, called ARID1A and GPBP1, could contribute to ovarian cancer's ability to develop resistance to this class of drugs.

«In hybrids we think there's a breakdown in the interaction of the organism's genes with those of its microbiome, and that causes its death,» says Brucker, although the precise mechanism is uncleaIn hybrids we think there's a breakdown in the interaction of the organism's genes with those of its microbiome, and that causes its death,» says Brucker, although the precise mechanism is uncleain the interaction of the organism's genes with those of its microbiome, and that causes its death,» says Brucker, although the precise mechanism is unclear.

«We identified, across the genome, that enhancer RNAs were the most common type of RNA that bound to CBP, and that by making this interaction, eRNAs play a crucial role in regulating CBP activity and gene expression.»

In the early stages of plant regeneration, plants benefit from the interaction with animals: bees pollinate flowers and maintain gene flow among plant populations, while birds disperse seeds that can establish as seedlings at new locations.

«Along with previous examples of small RNA exchange between fungi and plants, our results imply that this cross-species gene regulation may be more widespread in other plant - parasite interactions,» said Michael J. Axtell, professor of biology at Penn State and an author of the paper.

The difference in the hormone's effect for male and female progeny is related to the interaction of the estradiol and the genes determining the sex and throat color of the lizards.

Molecular analysis showed that heart cells in affected animals were poorly developed and had mitochondrial defects, indicating that Sap130 - Pcdha9 gene interactions play a crucial role not only in heart development but also in regulating metabolic function of the cardiac muscle.

However, animals that had mutations with Pcdha9, but not Sap130, can display defects in the aorta, but with normal - sized left ventricles, suggesting interaction between the two genes is needed to cause all the features of HLHS,» said Xiaoqin Liu, M.D., Ph.D., the first author of the new study and a research instructor in Lo's lab.

That is, there would be interactions with changes in lifestyle, just as Tuomilehto's diabetes genes have to be environmentally tripped.

«This is a very important discovery that will guide future research efforts to explore the interactions of these pigmentary genes with other genetic and environmental risk factors in cancers not linked to sun exposure, such as eye melanoma.

«It's quite probable that interactions between genes are critical in those fortunate enough to live very long, healthy lives.»

They built a new software tool called MIxT (Matched Interactions across Tissues) that uses computational and statistical methods to find and investigate links between gene expression in different body tissues.

This interaction is explained by divergent evolution occurring among paralogs of an essential duplicate gene, for which the functional copy is not located at the same locus in different accessions.