Sentences with phrase «gene interactions involving»

It includes more than 14,000 drug - gene interactions involving 2,600 genes and 6,300 drugs that target those genes.

Not exact matches

We confirmed this gene — environment interaction in two birth cohorts, and we ruled out alternative explanations of the finding involving gene — exposure correlation, intrauterine growth, social class, and maternal cognitive ability, as well as maternal genotype effects on breastfeeding and breast milk.

The huntingtin gene encodes a large scaffold protein, with many interaction partners, which is thought to be involved in intracellular trafficking.

«Fascinating genetic studies had been done on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature Genetics paper.

They achieved this by transiently disturbing interactions between target genes and PcG proteins, which are complexes involved in the repression of several genes governing development.

Studies seeking subtle signs of selection in the DNA of humans and other primates have identified dozens of genes, in particular those involved in host - pathogen interactions, reproduction, sensory systems such as olfaction and taste, and more.

«Our work helps us to understand what causes human diversity in appearance by showing how genes involved in pigmentation subtly adapted to external environments and even social interactions during our evolution.

The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.

«The database is a precious resource for the research community studying plant - microbe interactions as it is an unbiased way to identify potentially interesting genes involved in interaction with a plant — including many totally novel genes.

Bailey's laboratory is now working to unravel the genes and developmental pathways involved, as well as their interactions with the rest of the cricket genome.

«We want to identify the genes responsible for the interaction between plant and bacteria and meanly the ones involved with the nitrogen uptake,» Fernanda said.

Such disorders are caused by complex interactions among genes and environmental factors; the challenge facing researchers now is to find out which genes are involved and how they influence disease.

Human athletic performance involves interactions of some 220 genes; the situation is likely to be the same in horses.

They modernized the factory by updating the carboxysome, a particularly complex BMC that requires a series of protein - protein interactions involving at least six gene products to form a metabolic core that takes CO2 out of the atmosphere and converts it into sugar.

By representing data in BioPAX, Pathway Commons is able to provide a detailed representation of a variety of biological concepts including: Biochemical reactions; gene regulatory networks; and genetic interactions; transport and catalysis events; and physical interactions involving proteins, DNA, RNA and small molecules and complexes.

But this study showed an unexpected physical interaction between Pax3, p53, and Mdm2 that did not involve attaching to DNA or switching genes «on» or «off.»

After acknowledging that there can be complicated interactions between genes, and that DNA insertion might influence regulatory networks involved in many genes, it also should be remembered that the original discovery of genes was only possible because disruption of a gene causes a limited set of changes to the organism, such as a change in eye colour.

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

Our results suggest that ion channel gene expression and protein interactions display a modular structure that may be involved in stabilizing phenotype.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

However, the current P. cynomolgi B reference is very fragmented13, and lacks large parts of the subtelomeric regions, thought to harbour genes involved in host - parasite interactions.

In this review, I highlight the main genes known to cause uncommon monogenic forms of diabetes (e.g. maturity - onset diabetes of the young — MODY — and insulin resistance syndromes), as well as describe some of the main approaches used to identify genes involved in the more common forms of T2D that result from the interaction between environmental risk factors and predisposing genotypes.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Genes involved in conceptus - endometrial interactions in ruminants: Insights from reductionism and thoughts on holistic approaches

The gene expression viewer has proven to be an ideal tool for comparing gene family members, genes whose products participate in ligand — receptor interactions, and genes involved in signal transduction pathways.

Moreover, these joint data from humans and mice provide the first evidence that neurodegenerative effects of airborne PM may involve gene - environment interactions with APOE ɛ4, the major genetic risk factor for pathological brain aging and AD.