"Gene knockdown" refers to reducing the activity or expression of a specific gene in an organism. It is a technique used in genetic research to study the effects of inhibiting or decreasing the function of a particular gene.
Full definition
Heritable and inducible
gene knockdown in astrocytes or neurons in vivo by a combined lentiviral and RNAi approach.
«What we're excited about is how it only takes a very small amount of RNA to
cause gene knockdown in the whole liver.
«DEMETER
models gene knockdown and seed effects within the data, and computationally subtracts the seed effects.
Additional experiments,
including gene knockdown, surfaced prohibitin as a likely infection aide; prohibitin is a multi-functional protein found in human cells and in many other organisms.
This could be due to
incomplete gene knockdown, the presence of another body pigment in analogy with the Drosophila eye, or accumulation of colored intermediates in ommochrome biosynthesis (for instance, kynurenine imparts a yellow color to the eyes of deep - sea fish; Thorpe et al., 1992).
The Gross Lab at UCSF recently deposited 2 Bacillus subtilis libraries with Addgene — the B. subtilis Single Gene Deletion Library — Kanamycin and the CRISPRi
Essential gene Knockdown library.
In contrast, in a «
gene knockdown» scientists block protein production using particular substances, e.g. microRNAs.