Sentences with phrase «gene knockdown in»

«What we're excited about is how it only takes a very small amount of RNA to cause gene knockdown in the whole liver.

Not exact matches

«If the gene has been blocked in a knockdown, blood vessels do not develop normally,» explains Andrea Rossi, together with Zacharias Kontarakis first author of the study.

In contrast, in a «gene knockdown» scientists block protein production using particular substances, e.g. microRNAIn contrast, in a «gene knockdown» scientists block protein production using particular substances, e.g. microRNAin a «gene knockdown» scientists block protein production using particular substances, e.g. microRNAs.

«In addition, our study illustrates the power of comparing knockouts and knockdowns to identify modifier genes, a goal that remains a major challenge in the field of human genetics» says StainieIn addition, our study illustrates the power of comparing knockouts and knockdowns to identify modifier genes, a goal that remains a major challenge in the field of human genetics» says Stainiein the field of human genetics» says Stainier.

Additional experiments, including gene knockdown, surfaced prohibitin as a likely infection aide; prohibitin is a multi-functional protein found in human cells and in many other organisms.

Additionally, the study showed that genetic knockdown of RASAL2 gene can lead to reduced metastasis in breast cancer mouse model.

This could be due to incomplete gene knockdown, the presence of another body pigment in analogy with the Drosophila eye, or accumulation of colored intermediates in ommochrome biosynthesis (for instance, kynurenine imparts a yellow color to the eyes of deep - sea fish; Thorpe et al., 1992).

Researchers typically use viruses for two types of studies --(1) knock - in; introducing a protein - coding gene into cells to study its function, or (2) knockout / knockdown; studying gene function through deletion (potentially using CRISPR lentivirus knockout libraries) or reduction of gene expression, respectively.

Partial knockdown of this gene resulted in atypical behavior in 7 dpf larvae, as was measured in DanioVision using a light - dark - light paradigm (15-45-45 minutes).

Knockdown of both dec1 and per2 genes resulted in a noticeably disrupted circadian locomotor activity pattern.

(A) CummeRbund heat map of genes that were differentially expressed in control and single and double ABL1 and ABL2 knockdown cells.

We found that 180 genes showed significantly decreased expression and 40 genes showed significantly increased expression in ABL1 / ABL2 knockdown cells (fig.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

In order to amplify the efficiency of shRNA - mediated gene knockdown, UAS - dicer1 was constructed.

Many of the DNMT1 peaks were lost after DAXX knockdown (2,237 DNMT1 peaks in WT (Figure 2C) vs. 600 DNMT1 peaks in DAXX K / D (Figure 2E)-RRB-, indicating that DNMT1 recruitment is almost entirely dependent on DAXX further corroborating previous findings that DAXX recruits DNMT1 to repress its target genes [2].