Sentences with phrase «gene locus»
The phrase "gene locus" refers to a specific location on a chromosome where a particular gene is located. It is like an address that points to the spot where a specific gene is located in the DNA sequence. Full definition
From the genome wide scan, a set of gene loci correspond to thermostatic regulation has been identified.
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To demonstrate the critical role for ecRNA - directed methylation, first author Katherine Savell, a graduate student in the Day lab, blocked one specific ecRNA for the Fos gene locus in the hippocampus of the rat brain.
The human T cell receptor beta (TRB, previously known as TCRB) gene locus on chromosome 7 (7q34) includes 65 Vb (variable) gene segments, followed by two separate clusters of genes each containing a Db (diversity) gene, several Jb (joining) genes, and a Cb (constant) region spread over 685 kilobases.
This mechanism coordinates transcription with chromosomal architecture by linking dispersed gene loci with centromeres.
The pre-publication data that we release via this website is embargoed for publication except for analyses of single chromosomes in single strains or single gene loci across multiple strains.
Mature miR - 7 is individually transcribed and processed from 3 different gene locus in human genome, and it is highly expressed in parts of the brain, eye, and pancreas, suggesting its role in the development of these organs (20 — 22).
Allelic effects at the major gene locus showed nearly to complete dominance, with a recessive, unfavourable allele in both traits.
Effects of the genotypes were in m, with m ′ = (− a, d, d, a), where a was referred to as the additive and d as the dominant effect at the major gene locus.
That can make it hard to make subtle changes to a gene — like introduce point mutations corresponding to natural variations linked with human disease — without taking a sledgehammer to the entire gene locus.
PRC - dependent and H3K27me3 - associated gene silencing by EBNA3A and EBNA3C has however been convincingly demonstrated at multiple gene loci (Skalska et al., 2010; Harth - Hertle et al., 2013; Kalchschmidt et al., 2016b; McClellan et al., 2012; 2013).
Six gene loci here displayed a clear association with the FVC values.
Published in Nature, new findings detail a new gene locus that can explain why, in communities where everyone is constantly exposed to malaria, some children develop severe malaria and others don't.
This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.
This cascade of activity enables PRC2 to spread this modification over the entire neighboring gene loci, thereby marking it for silencing.
In mice heterozygous for tau - lacZ targeted to the melanopsin gene locus, β - galactosidase — positive RGC axons projected to the SCN and other brain nuclei involved in circadian photoentrainment or the pupillary light reflex.
You're looking at the association of Lp (a) levels in the well - known LPA gene locus.
The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.
Our results have revealed that although condensin and cohesin bind to the same gene loci, they direct different association networks (Figure).
Blue and red lines represent gene contacts between two gene loci positioned more than and less than 100 kb away, respectively.
Furthermore, our results have revealed that centromeric motion, which is controlled by cytoplasmic microtubules, contributes to the mobility of non-centromeric gene loci.
In the figure: A model for the role of centromeric motion in the mobility of many gene loci during interphase.
We have already screened several candidate genes in Old English Sheepdogs with PRA and also screened gene loci which cause PRA in other breeds.
GWA studies of type II diabetes identified nearly 20, robustly replicating gene loci.
The recommendation is to check for interaction with other polymorphisms (see, for example the replicability of «novelty seeking», where interaction of at least three gene loci made replication uncertain [122].
Experiments by the UAB researchers included both a broad, genomewide look at ecRNAs and gene expression, and a detailed example using the Fos gene locus.
Centromeres associate with dispersed gene loci, and these gene contacts are mediated by condensin.
The Canadian Patent Office would have to reverse the Patent licenses it has granted to companies who have received them for what's called single gene loci.
«As the gene loci that had previously been associated with DLB were also implicated in Alzheimer's and Parkinson's, it was unclear if DLB's genetic roots were simply a combination of the other two diseases.
They also found preliminary evidence for a gene locus that had not been previously associated with DLB, but the results did not reach significance.
Experts believe that the gene loci discovered to date explain at most 5 percent of problematic behaviors.
The researchers also provided a detailed analysis of ecRNAs arising from the Fos gene locus.
Long - term efforts in our research group have been directed towards uncovering the unique pathway for the differentiation of Vα14 iNKT cells, which require a different selecting cell type in the thymus that probably imprints the activated phenotype in these cells, including the opening of the gene loci encoding IL - 4 and IFNγ.
We propose that centromeres serve as «Genome Flexibility Elements» by connecting dispersed gene loci to highly mobile centromeres (Kim et al..
Samples were then forwarded from the University of California, San Diego - Comparative Neuromuscular Laboratory to the University of Minnesota Canine Genetics Laboratory and they identified a gene locus on chromosome 36 as the probable affected locus on the affected dogs.