Sentences with phrase «gene locus in»

Mature miR - 7 is individually transcribed and processed from 3 different gene locus in human genome, and it is highly expressed in parts of the brain, eye, and pancreas, suggesting its role in the development of these organs (20 — 22).

To demonstrate the critical role for ecRNA - directed methylation, first author Katherine Savell, a graduate student in the Day lab, blocked one specific ecRNA for the Fos gene locus in the hippocampus of the rat brain.

Not exact matches

Simulating the yield impacts of organ - level quantitative trait loci associated with drought response in maize: A «gene - to - phenotype» modeling approach.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioIn this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioin three loci associated with extrinsic epigenetic age acceleration.

For example, in sporadic PD, multiple GWAS point to the alpha - synuclein gene (SNCA) as one of the strongest risk loci in patients» genomes, yet GWAS contain little information regarding the mechanism of how this gene is dysregulated in sporadic PD patients.

A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.

They then used a genetic technique called quantitative trait locus analysis to search for the genes involved in generating phenolics in the most promising progeny.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micIn their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micin the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

Although many different malaria resistance loci have been postulated over the years, this is one of very few that have stood up to stringent testing in a large multi-centre study; the others include the genes for sickle cell and the O blood group.

The new locus they have identified is near a cluster of genes which code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood cells.

The second locus significantly correlated with severe CCD was on chromosome 11, the same chromosome that contains a gene thought to increase the risk of schizophrenia in humans.

In this study, researchers found that the Bt locus was delimited to a 442 - kb region on chromosome 5 that harbors 67 predicted genes.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

The puffy appearance was a known sign that genes were being activated in those regions to give rise to their encoded proteins, so those sites of activity became known as the heat shock loci.

This interaction is explained by divergent evolution occurring among paralogs of an essential duplicate gene, for which the functional copy is not located at the same locus in different accessions.

Analyzing the DNA of about 3,500 diagnosed people and nearly 11,000 without the disorder, researchers homed in on a genetic locus — a gene's location on a chromosome — that's involved in the body's metabolic processes and seems to be associated with the disorder.

«As the gene loci that had previously been associated with DLB were also implicated in Alzheimer's and Parkinson's, it was unclear if DLB's genetic roots were simply a combination of the other two diseases.

Prof Bentzen from Dalhousie University said: «Although this study focused on MHC genes in vertebrates, the evolutionary dynamics described in it likely apply to other gene families, for example resistance genes and those which prevent self - fertilization in plants (self - incompatibility loci) that are caught up in their own evolutionary races.»

In mice heterozygous for tau - lacZ targeted to the melanopsin gene locus, β - galactosidase — positive RGC axons projected to the SCN and other brain nuclei involved in circadian photoentrainment or the pupillary light refleIn mice heterozygous for tau - lacZ targeted to the melanopsin gene locus, β - galactosidase — positive RGC axons projected to the SCN and other brain nuclei involved in circadian photoentrainment or the pupillary light reflein circadian photoentrainment or the pupillary light reflex.

Importantly, Calo found that these small RNAs only silenced the FKBP12 gene and not any other loci in the genome.

«If we can identify similar genetic loci in people, and if we could find biomarkers for these gene - environment interactions, then perhaps we could develop a simple blood test that identifies people who are at high risk of cancer from low - dose radiation,» says Mao.

In this latter group, they found thirteen gene - environment interactions, also called «genetic loci,» which contribute to the tumor susceptibility when the mouse is exposed to low - dose radiation.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

This is the case at the level of loci (e.g. identifying causal variants underlying genome - wide associations), genes (e.g. understanding not only that mutations in gene X underlie a given phenotype, but also the how and why of it), and variants (e.g. variants of uncertain significance).

Further, his group pioneered expression quantitative trait locus (eQTL) studies, which enabled variation in global gene expression to be applied to genetics of complex human diseases.

Other accomplishments in this area include the mapping of variation in the FTO gene for obesity, characterizing the role of interleukin (IL)-6, IL - 10, and IL - 1RA in obesity and insulin resistance in African Americans (AA), and determining the loci associated with CRP, IL - 10, IL - 1Ra, and IL - 6 levels in a GWAS of AA.

From this large sample comprising a quarter of the fly genome we estimate that there are approximately 3600 lethal loci in a Drosophila genome of 12,000 genes (Table 2).

GWAS loci in 5 genes reaching genome - wide significance for BP were identified.

Disrupting «Silent» Genes The number of transcripts appears to exceed the number of mutable loci in several extensively analyzed segments of the Drosophila genome (34 - 35).

In collaboration with deCODE Genetics, susceptibility loci for T2D were identified in three genes (TCF7L2, CDKAL1, and TCF2 [HNF1β]-RRBIn collaboration with deCODE Genetics, susceptibility loci for T2D were identified in three genes (TCF7L2, CDKAL1, and TCF2 [HNF1β]-RRBin three genes (TCF7L2, CDKAL1, and TCF2 [HNF1β]-RRB-.

Type I parasites are typically highly lethal in mice; however, the recent identification of ROP5 genes as the mediators of acute virulence and the generation of attenuated parasites lacking this locus [16], [17] permits long - term Type I infection studies in mice, perhaps due to a non-persistent infection following Immunity Related GTPase - mediated clearance.

Targeted Gene Addition to a Safe Harbor locus in human CD34 + Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.

Our first striking observation was that over one half of measured genes are affected by common genetic variation in human populations — called expression quantitative trait loci or eQTLs.

It will be important in future studies to improve both gene and taxon sampling for primate species, to construct separate trees based on mitochondrial and nuclear loci, and to tease apart differences that arise from incomplete lineage sorting versus other types of discordance including introgression and sex - biased dispersal [75]--[77].

Effects of ploidy and sex - locus genotype on gene expression patterns in the fire ant Solenopsis invicta.

The antigen receptor genes that undergo rearrangements are the immunoglobulin heavy chain (IGH) and light chain loci (IGK and IGL) in B cells, and the T cell receptor gene loci (TRA, TRB, TRG and TRD) in T cells.

Recent genetic association studies identified variants in a locus on chromosome 15 (specifically, in the adjacent genes HERC2 and OCA2) that are major determinants of eye color, but the trait is influenced by interaction among at least ten different genes.

Each locus found in GWAS spans a number of genes.

Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases.

Single loci with major effects in fire ants: the effects of the complementary sex - determining locus and the green beard supergene on gene expression

Reykjavik, September 19th, 1999 — deCODE genetics, Inc. announced today that they have identified a locus on chromosome 2p13 that contains a gene that is linked to pre-eclampsia in women — a condition that is indicated in an estimated three to seven percent of...

However, they were not designed to delineate regions of the genome resisting introgression nor investigate the frequency and types of genes involved in genetic incompatibilities, because they were based on a relatively small number of loci (less than 50) and the sampling of the genome was non-random (e.g. overrepresentation of the X-chromosome or regions near centromeres).

We note that loci characterized by high levels of differentiation, which are likely to be resisting introgression, were included in our estimates from previous studies; therefore, if anything, the estimates of gene flow used in the simulations are likely to be underestimates, and our results should therefore be conservative.

Given this pattern, genomic regions that are enriched for fixed differences are likely to be maintained by selection against introgression and thus contain genes involved in hybrid incompatibilities (or loci experiencing selection at linked sites within subspecies; see below).

The majority of these loci correlate with non-coding genomic regions, underscoring that differences in DNA sequences located within melanocyte gene regulatory elements significantly contribute to melanocyte biology and disease.

Genetic studies using samples along the distribution range of both subspecies and based on a few dozen nuclear markers have revealed loci of relatively high divergence (0.3 — 1.2 %) between subspecies embedded in a genome otherwise characterized by low levels of differentiation and high levels of bidirectional gene flow [21], [24]--[26], likely facilitated by high effective population sizes, high dispersal, and a relatively short generation time [21], [24]--[26].

Any reads that map to multiple locations in the genome (also called multireads) are not counted towards the expression estimates since they can not be assigned to any gene unambiguously, but these provide evidence of transcription in at least one of the loci to which they map.

Consistent with this theoretical consideration, analysis of gene products from adjacent loci (guaA / B and BBB22) demonstrated comparable levels in B31 - A3 WT, ospC mutant, and complemented bacteria (data not shown).

In order to extract the candidates with greatest probability of encoding protein coding genes, we cross-referenced all predicted loci to the Ensembl databases using the API [54].