Allelic effects at the major
gene locus showed nearly to complete dominance, with a recessive, unfavourable allele in both traits.
Not exact matches
In their study, the researchers
showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4
gene was less methylated at four specific
loci, i.e. epigenetically altered, compared to the other mice.
Hanner and Rusche used chromatin immunoprecipitation assays to
show that this chimeric protein did not make it to the HMRa or HMRα
loci or to other repressed
genes.
A more recent study using individuals sampled across the hybrid zone and 22 markers
showed that some
loci are characterized by concordant and stepped clines that do not co-localize with any obvious physical or ecological barriers [27], suggesting an overall barrier to
gene flow likely to be primarily maintained by selection against intrinsically unfit hybrids.
Venus positive cells experiencing low - level transcription at the Hex
locus, but still expressing the ES cell markers SSEA - 1 and Oct4,
show elevated levels of PrEn
gene expression and reduced levels of early ICM markers such as Nanog.
Consistent with this theoretical consideration, analysis of
gene products from adjacent
loci (guaA / B and BBB22) demonstrated comparable levels in B31 - A3 WT, ospC mutant, and complemented bacteria (data not
shown).
It is important to distinguish lineage specific
gene expression
shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many
loci noted previously in ES cells [23].
«E», normal extension of black, allows the A-series alleles to
show through, and «e», recessive red / yellow, overrides whatever
gene is present at the A
locus to produce a dog which
shows only phaeomelanin pigment in the coat.
Such a dog will carry the
genes for arranging pigment granules in the nose and other integument to
show black, liver, or blue, but nothing at the E
locus that allows anything other than tan hairs (or tan with brindle striping).
The adult offspring of high compared to low maternal care mothers
show epigenetic changes in promoters, exons, and
gene ends associated with higher transcriptional activity across many
genes within the
locus examined.