Sentences with phrase «gene loss»

ET: «What this data analysis pipeline, moreover, creates is motivation to look for similar forms of gene loss in other types of symbioses, such as that between humans and their gut microbiomes.

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.

Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.

«Combining images, genetic data proves gene loss behind aggressive ovarian cancers.»

Gene loss tends to happen when bacteria settle into a comfortable environment and no longer need certain functions, von Dohlen says, and it is what researchers think happened to organelles.

We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs.

Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90 % of X-linked genes into those with functional or nonfunctional Y homologs.

Comparative genomics analyses with uncultivated environmental TM7 assemblies show remarkable conserved gene synteny and only minimal gene loss / gain that may have occurred as TM7x adapted to conditions within the human host.

They study processes such as gene loss and duplication, speciation, functional conservation and horizontal gene transfer.

A surprise of the research is that M. leprae has experienced extensive gene loss.

On the other hand, too much CIN leads to lethal gene loss and genome damage.

These broad associations with complexity are evidently superimposed on notable lineage - specific variation as seen in Fig. 4 (for example, serine protease gene loss in C. elegans, and voltage-gated ion channel expansion in Paramecium).

«Since the substance did not cause disturbances in blood vessel growth, we thought of a different mechanism: The gene loss could be compensated by another gene taking over the function,» Kontarakis says.

Yet despite the MAD1 / 2 gene loss, planarians retained the checkpoint function.

This gene loss can then, in some rare cases, cause large enough changes to demonstrate a genetic function that can be targeted.

mutation (s) of a gene loss of a copy or reduced expression of a gene increased expression of a gene reliance on a gene functionally or structurally related to another, lost gene (a.k.a., a paralog dependence)

Gene loss, silencing and activation in a newly synthesised a wheat allotetraploid.

Typically after an allotetraploid is formed, the genome will experience downsizing and gene loss, eventually transforming the new species back into a diploid.