Sentences with phrase «gene loss in»

These broad associations with complexity are evidently superimposed on notable lineage - specific variation as seen in Fig. 4 (for example, serine protease gene loss in C. elegans, and voltage-gated ion channel expansion in Paramecium).

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.

ET: «What this data analysis pipeline, moreover, creates is motivation to look for similar forms of gene loss in other types of symbioses, such as that between humans and their gut microbiomes.

Owing to residual incompleteness of the sponge genome draft, and possible gene losses in the Amphimedon lineage, this analysis provides a conservative estimate.

Not exact matches

Advances in molecular biology and bioinformatics have led to an explosion of research on the causes of hearing loss and how to fix it with drugs or gene therapy.

Shares of biotech Spark Therapeutics rose 4.5 % in early Monday trading after the Food and Drug Administration (FDA) agreed to review its gene therapy for vision loss patients who have vision loss due to a rare genetic condition called biallelic RPE65 - mediated inherited retinal disease (IRD).

«Today's approval marks another first in the field of gene therapy — both in how the therapy works and in expanding the use of gene therapy beyond the treatment of cancer to the treatment of vision loss — and this milestone reinforces the potential of this breakthrough approach in treating a wide - range of challenging diseases,» FDA Commissioner Scott Gottlieb said in a statement.

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

Other factors such as hormones and genes also cause hair loss, but the key factor is the deficiency in nutrients.

It may be that some versions of the gene also play a role in deafness caused by environmental conditions, creating a predisposition to hearing loss.

The scientists from the Montreal Neurological Institute and Hospital at McGill University, led by Peter McPherson, along with collaborators in Saudi Arabia, Jordan, Germany, and at SickKids Hospital and the University of Toronto, have discovered that a severe form of epileptic encephalopathy is caused by recessive loss - of - function mutations in the gene DENND5A.

In subsequent analyses, striking losses in gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioIn subsequent analyses, striking losses in gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin gene expression.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

Robl and Stice, in collaboration with the biotech company Genzyme of Cambridge, Massachusetts, have already created embryos that contain the human gene for albumin protein, which helps restore the blood's osmotic pressure after blood loss.

«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»

This study represents a significant step towards the development of clinical trials in gene therapy for the curative treatment of hereditary deafness and balance loss in humans.

These results indicate that the large losses of cloned cows before implantation probably result from problems with critical developmental genes in the extraembryonic tissue.

This area has not been explored in depth, since experience with other diseases has taught scientists that the loss of one gene copy might not lead to disease symptoms because the second copy provided by the other parent fills in.

A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss - of - function mutations to Filaggrin - 2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics — an alteration that results in the loss or gain in a copy of a gene.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

So, for example, just to say for the sake of argument, that there's a gene that influences the width of the birth canal, and lets say that some versions of the gene leave women more likely to have trouble giving birth, so that their children have loss of oxygen and that could lead to changes in the brain that lead to lower intelligence scores.

The French team and a British group that discovered the mouse gene both decided to see if the mutation — which hampers the production of a protein called myosin VIIA — might, as in the mice, explain inherited deafness without other sensory loss.

Deafness has long been known to run in families, and while genes for about 60 syndromes that have deafness as one of multiple symptoms have been mapped, only last month did scientists locate the first of the estimated 100 genes that can cause hearing loss alone.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

«Gene therapy restores hearing in deaf mice: Proof - of - principle study takes a step toward precision medicine for genetic hearing loss.»

In 2006, the team led by Christine Petit in the Institut Pasteur's Genetics & Physiology of Hearing Unit, especially Sedigheh Delmaghani, working in cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early - onset sensorineural hearing losIn 2006, the team led by Christine Petit in the Institut Pasteur's Genetics & Physiology of Hearing Unit, especially Sedigheh Delmaghani, working in cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early - onset sensorineural hearing losin the Institut Pasteur's Genetics & Physiology of Hearing Unit, especially Sedigheh Delmaghani, working in cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early - onset sensorineural hearing losin cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early - onset sensorineural hearing loss.

Tallying the genes that were most perturbed by loss of Lef1 in this brain region revealed that over 20 were involved in mood disorders like depression and anxiety.

Identification of the genes represents a vital step toward developing compounds that can be used in targeted, individualized treatment of severe periodontitis, before loss of teeth and supportive bone occurs.

Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations.

One type had the TMC1 gene completely deleted, and is a good model for recessive TMC1 mutations in humans: Children with two mutant copies of TMC1 have profound hearing loss from a very young age, usually by around 2 years.

However, Holt's study also showed that gene therapy with TMC2 could compensate for loss of a functional TMC1 gene, restoring hearing in the recessive deafness model and partial hearing in the dominant deafness model.

But what did change: genes that during development would normally cause the loss of connections between neurons were switched on again in the aging astrocytes.

If it weren't for telomerase, this gradual shortening would eventually lead to the complete loss of the telomeres in cells that replicate frequently during a life span, and thus the gradual erosion of the genes themselves.

In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humansIn the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humansin these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humansin humans).

In a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesionIn a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesionin mice led to significantly less scratching and less severe skin lesions.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

Christiano's lab uses specially bred mice to pinpoint genes involved in hair loss.

A case in point: the new gene therapy for Leber congenital amaurosis, the eye disorder that causes progressive loss of vision, usually leading to complete blindness by age 40.

The latest findings offer new focus points into how these genes and others may be modified to fine - tune a wheat variety for a particular environment, which will result in less crop and food loss due to changing environment.

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells grow.»

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

«When people hear that genes may be playing a role in their weight loss success, they don't say, «Oh great, I just won't exercise any more,»» says Bray.

But they think that by looking at some of the chemical basis of, you know, weight loss and / or weight gain, then by manipulating it — and they also look for the genes involved in these chemical signals — then they can possibly translate that into drugs for humans or just understanding better the mechanism of weight loss and weight gain.

For the manatee, walrus, dolphin, and killer whale, the return to the sea involved many evolutionary trade - offs amongst hundreds of genes: a general loss of the number of sensory genes for smell and taste, new functions for genes forming skin and connective tissue, and genes involved in muscle structure and metabolism.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

Loss of paternally expressed genes leads to psychosis in at least half of these patients.

«This raises the possibility that mutations in the Ggamma13 gene may contribute to certain forms of human anosmia and that gene sequencing may be able to predict some instances of smell loss.»

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

The loss of beta cell function may be driven by a defect in Clec16a, a gene responsible for getting rid of old mitochondria, the powerhouses of cells, and making room for fresh ones.