Sentences with phrase «gene map approaches»

As the cost for a full gene map approaches $ 1,000, the opportunity increases for business owners to get in on the genome mapping industry.

Not exact matches

But the genetic factors underpinning seed coat permeability remained a mystery until Ma and his team used a map - based cloning approach to hone in on GmHs1 - 1 as the gene responsible for hard seededness.

The team also exploited a genomic mapping approach similar to those applied in sexually reproducing organisms to localize the mycobacterial genes that determine mating identity.

So when the US National Genome Project started three years ago, a group of influential molecular biologists led by James Watson decided that the sensible approach would be to concentrate first on mapping the genes and finding out their functions.

Because many of the genes influencing facial morphology are likely to have small effects, successfully mapping a large number of these genes will require much greater sample sizes and a more comprehensive approach to quantifying facial features of interest.»

This approach has contributed to the successful mapping of genes involved in numerous human diseases such as Huntington's disease and cystic fibrosis, an important first step in understanding these conditions.

Utilizing genetic approaches such as «fine mapping» and «genome editing,» the researchers narrowed the region of the chromosome and targeted each gene to responsible for affecting the behavioral response to the drug.

A high throughput in vivo protein - DNA mapping approach reveals principles of dynamic gene regulation in mammals / M. Garber *, N. Yosef *, A. Goren, R. Raychowdhury, A. Thielke, M. Guttman, J. Robinson, B. Minie, N. Chevrier, Z. Itzhaki, A. Weiner, D. Friedrich, J. Meldrim, O. Ram, C. Chang, A. Gnirke, S. Fisher, N. Friedman, B. Wong, B. Bernstein, C. Nusbaum, N. Hacohen, A. Regev, I. Amit.

In the new research, Pollen and co-first author Tomasz Nowakowski, PhD, also a postdoctoral researcher in the Kriegstein lab, partnered with Fluidigm Corp. to develop a microfluidic approach to map out the transcriptional profile — the set of genes that are actively producing RNA — of cells collected from the VZ and SVZ during embryonic development.

Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Our approaches include gene discovery, mapping of signaling networks in cell culture models and in vivo functional analyses done through gene knock - out and knock - in techniques in mice.