Sentences with phrase «gene mapping studies»

Despite strong evidence that genetics is important in determining the risk of idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs or humans.

Not exact matches

The most compelling comes from the study of genes, especially now that the Human Genome Project has been completed and the genomes of many other species being constantly mapped.

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

Finally, the authors addressed two major challenges for any study that generates large data - sets of individual genes and proteins in model organisms like yeast: How to assemble the data into coherent maps?

«Interactomes like this one make the whole debate of genes versus the environment a lot more sophisticated,» adds Vidal, who was not involved in the current study and who mapped a network involved in breast cancer susceptibility in 2007.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

«In this study we mapped the interacting regions in both genes in order to begin the process of developing drugs that can fill in these spaces and block the genes from binding,» says Fisher.

The unmapped DNA also sometimes resembles known, mapped genes, which can interfere in attempts to study similar sequences.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

«Gene mapping lays groundwork for precision chemotherapy: First - of - its - kind study maps links between 625 genes and 31 different chemotherapy treatments.»

«First, there is no single road map to eusociality — the complex, cooperative social system in which animals behave more like superorganisms than individuals fending for themselves,» said Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.

Axel Diederichsen, curator of Plant Gene Resources of Canada in Saskatoon, says the new study's effort to document and map missing wild diversity is valuable.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

«Mapping the genes that increase lifespan: Comprehensive study finds 238 genes that affect aging in yeast cells.»

Uncovering the genetic pathogenesis of Alzheimer's disease has been a target of great interest over the past few years, and genome - wide mapping studies focusing on risk genes have led to significant advances in the field.

The three stages of CD8 + T cell development are well known, but the current study identifies a detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving genes to transcribe proteins to carry out biological processes.

For example, many studies on human microbiota identify species (or operational taxonomic units) and map evolutionary relationships using the 16S ribosomal RNA gene.

In their comprehensive study, which involved a search of gene activity maps as well as testing of human brain tissue, the researchers identified more than 100 enhancers which were much more active in the brain than in other tissues.

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In the present study, to elucidate the neural mechanism underlying this behavior, we used an immediate early gene (IEG) to map the active brain regions of Japanese honeybee workers during the formation of a defensive bee ball.

Their study used a pioneering genetic technique to analyse maps of DNA regions linked to an inherited risk of breast cancer and identify the actual genes involved in raising a woman's risk.

Most recently, she has led the planning and execution of a program for a new gene therapy product candidate, from ideation through proof - of - concept study, and mapping out the development plan.

Recent studies have started to map the gene - wide chromatin interactions in the interphase nucleus, revealing some principles of chromosome organization into territories, and dramatic changes of chromatin organization and interactions during differentiation and lineage specification.

In the most detailed large - scale study to date of the proteins that package DNA, researchers have mapped a family of switches that turn genes on and off.

Interestingly, two studies of melanoma cell lines revealed frequent mutations in mitogen activated protein (MAP) kinase kinase [kinase] genes MAP2K1, MAP2K2, MAP3K5, and MAP3K9.

The current SNP map now makes it possible for genome - wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

The study, «A gene - based association method for mapping traits using reference transcriptome data,» was funded by the National Institutes of Health.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

And now, thanks to some fancy facial mapping software and a big data - driven study, researchers have identified certain variants of a gene that may be responsible for why some people look older than they are.

From studying genes and circuits, to healthy behavior and psychiatric disorder, the institute's faculty contribute expertise to routinely produce insights and tools to see, map, understand and fix problems in the nervous system.

The 2013 study, which was led by David Altshuler (now chief scientific officer at Vertex Pharmaceuticals), had shown that one gene in that region, SLC16A11, harbored several suspicious mutations, and more detailed genetic mapping of the region strengthened the case for focusing on it.

The gene was mapped to a small region on chromosome 18, which previous studies have suggested may play a role in blood pressure regulation in humans, mice and rats.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence varstudies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence varstudies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence varStudies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence varStudies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

These laboratories are complemented by several additional laboratories: one that is focused on computational structure prediction and design (Phil Bradley), one that conducts solution - based protein mapping studies of large complexes involved in gene transcription (Steve Hahn) and a third that conducts drug target validation and drug screening studies (Julian Simon).

Wednesday, Oct. 18, 11:00 - 11:15 a.m., Room 310A, South Building Platform Presentation: Redrawing the map of blood pressure genes in a transcriptome - wide association study of over 301,000 participants in the Million Veterans Program and 145,000 from UK Biobank D.R. Velez Edwards, Vanderbilt University Medical Center, et al