Sentences with phrase «gene networks in»

In principle this discovery could revolutionize saline agriculture worldwide by laying the groundwork of understanding necessary to appropriately using salt resistance genes and gene networks in crops to enable them to grow in desert and saline environments.

«Or we could use it to study the gene networks in diseases and get a better understanding of how those diseases work.»

Examples of gene networks in the hippocampus affected by brain trauma.

The ideal way to identify a gene network in humans would require an impossible experiment: Take two families, each with dozens of identical twins, and have the families interbreed, combining the same sets of genes together over and over again.

Not exact matches

«A person can always learn something new,» says Gene Brady, director at Search Consulting Network, which specializes in recruiting in the automotive, industrial and automation sectors.

«Twitter is one of the most widely used social media networks worldwide and despite the speed of technological innovation in the 21st Century, no other full - service bitcoin wallet offered this feature until now,» said Gene Kavner, founder and CEO of iPayYou as well as a former Amazon executive, as quoted by Pymnts.com.

Marshall points out that the relatively fast appearance of new animal species in this period is not driven by new genes, but rather by evolving from existing genes through «rewiring» of the gene regulatory networks (GRNs).

Often, the genes of the new are present in the body of the old — they are the ideas, the social movements, the fair food networks that start life on the innovative edge, the social fringe, and move towards the middle where they give expression to the new systems that grows out of the old.

Ongoing projects include studies of gene - environment interactions and adverse pregnancy outcomes, as well as informed medical decision making demonstration projects in Medicaid maternity populations and within HealthWise, the nation's largest source of health information materials distributed through healthcare networks.

He added that the method used in this study, called «network biology» — where computer systems are used to identify gene networks that work together to underpin disease — may also help find treatments for other conditions.

The genes in the network are thought to be involved in how brain cells communicate with each other.

What unites the sociologists, physicists, biologists, and other scientists studying networks is the recognition that «whether they're networks of people, computers, genes, [or] neurons, they often obey similar mathematical rules and have similar properties,» says Nicholas Christakis, a professor of sociology and of medical sociology at Harvard Medical School in Boston.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

Biologists could use an infusion of mathematics as well, says Iya Khalil, vice president of R&D at Gene Network Sciences Inc. in Ithaca, New York.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

These results suggest that ESR1 may play a pivotal role in modulating gene - regulatory networks after learning.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

The same gene network also plays a role in programming the fly neurons responsible for taste, the researchers report in the journal PLOS Genetics.

Several of the network genes Volkan and her team identified have counterparts in humans and other vertebrates, which suggests the same basic mechanism could be at work in building the nervous system in other animals too.

Doyle is now tackling a far bigger network of genes in E. coli: the master network responsible for governing its metabolism.

To learn which genes in the mussel make the byssal threads, the researchers first treated the threads with the enzyme pepsin to liquefy their interlocking networks of proteins.

The researchers would like to understand the genes and neuronal networks involved in regulating the avoidance behavior that occurs after high pH is sensed.

Expansive wars and annexation resulted in enlarged territories and favored genes that prescribe group cohesion, networking, and the formation of alliances.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

«Interactomes like this one make the whole debate of genes versus the environment a lot more sophisticated,» adds Vidal, who was not involved in the current study and who mapped a network involved in breast cancer susceptibility in 2007.

In animal models or petri dishes, scientists disable one gene at a time to see how it affects the proposed network.

Molecular geneticists dream of having a similarly comprehensive view of networks that control genes: For example, they would like to identify rules explaining how a single DNA sequence can express different proteins, or varying amounts of protein, in different circumstances (see p. 80).

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtIn addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtin the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

Complicating matters further, these genes seem to operate in large networks, interacting with each other and the environment to influence weight.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

Using a computational technique called network diffusion, the team identified networks of genes that are interrelated through their connection to the ASD genes in the databases.

The researchers developed a computational framework to determine the structure of protein interaction networks in each sample and infer which genes performed different cellular functions within these networks.

Remarkably, when the researchers manipulated the activity of these three genes, almost all of the other genes in the network were corrected, pointing to novel therapeutic targets for CAVD.

«By understanding the gene networks that get disrupted in CAVD, we can pinpoint what we need to fix and find new therapeutics to correct the disease process,» says first author Christina Theodoris, an MD / PhD student at the Gladstone Institutes and UCSF.

For example, many of the genes in the new networks are related to cancer, suggesting that certain cancer treatments that target these genes might also be useful to treat ASD.

Researchers from KTH Royal Institute of Technology's Science for Life Laboratory (SciLifeLab) research center and Gothenburg University employed the biological networks generated for 46 major human tissues in order to identify the liver - specific gene targets.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

Using a new technique that accounts for how genes interact, Italian researchers have identified new networks of related genes that may be involved in ASD — including genes that are related to cancer.

A given gene may perform a different function in breast cancer cells than in healthy cells due to changes in networks of interacting proteins, according to a new study published in PLOS Computational Biology.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

In the current study, the researchers report that NOTCH1 acts like a sensor on the endothelial cells — the cells that line the valve and vessels — detecting blood flow outside of the cell and transmitting information to a network of genes inside the cell.

Activation of NOTCH1 by blood flow causes a domino effect, triggering numerous other genes in the network to turn on or off, resulting in suppression of inflammation and calcification.

Uncovering the many genes in a network has proved to be maddeningly difficult, and humans are a terrible place to look for them.

By going gene hunting in the Phenome Room, Jackson Laboratory scientists hope to steer their colleagues away from the search for single genes in favor of hunting for gene networks.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

That's because stem cells must be connected to existing neural networks — something that's not yet possible — whereas gene therapy simply involves making what is left in a diseased eye photosensitive.

It is a crucial network in the nucleus, providing mechanical support to the nucleus and also regulating gene expression by making some areas of the genome less or more available to be transcribed into messenger RNA.

As part of this effort, Dr. Weinstein and his colleagues inserted a gene for a protein that turns green the cells that line the endothelium of selected embryonic veins and in the lymphatic system — the network of vessels through which immune cells travel in the body.