THE Australian Parliament's Standing Committee on Industry, Science and Technology seems to have let the genie out of the bottle, or rather,
the gene out of the laboratory.
Not exact matches
He immediately joined the
laboratory of Kenneth Burtis, identifying DNA - repair enzymes by crossing flies with
genes knocked
out.
For the new study, presented last week at the Biology
of Genomes meeting here, molecular biologist Marco Osterwalder
of Lawrence Berkeley National
Laboratory in Berkeley, California, and colleagues harnessed a powerful new
gene - editing technique called CRISPR to figure
out exactly how some
of these candidate enhancers work.
Biologist Michael Wigler
of Cold Spring Harbor
Laboratory, who led the study, started
out studying
genes in cancer cells but soon realized he was seeing unexpected patterns in the healthy cells he examined for reference.
When the researchers used
gene engineering techniques to knock
out DDX3 expression in
laboratory - grown cell cultures that highly expressed this protein, cell proliferation was half that
of cell cultures with high DDX3 expression.
The University Department
of Laboratory Medicine (Harald Esterbauer and colleagues) carried
out the
gene analyses (COMT Val158Met, BDNF Val66Met, 5 - HTTLPR).
To find
out more about how RNAi works, a team led by biochemist Scott Hammond
of Cold Spring Harbor
Laboratory in New York picked double - stranded RNA known to interfere with a
gene involved in promoting cell division.
The project came
out of a collaboration with Cold Spring Harbor
Laboratory to identify
gene pathways that could be used to breed crops with higher yields.
Working
out the functions
of these microbial
genes is a big challenge because many
of the microbes that live within us are extremely reluctant to grow when cultured under
laboratory conditions.
Call for concern Mindful
of both the potential and the risks, Esvelt, a bioengineer at Harvard Medical School in Boston, Massachusetts, brought together a group
of scientists to write a Comment in Science, published last week, laying
out the need for multiple containment strategies for
gene - drive research that is done in the
laboratory.
This is a unique scientific paradigm: the first publication determining the role
of human - specific
gene duplications during brain development came
out of our
laboratory recently (Charrier et al., 2012) and represents a milestone in our understanding
of the genetic and neurobiological mechanisms underlying the emergence
of human - specific traits
of brain development, for example neoteny during synaptic maturation (Benavides - Piccione et al., 2002; Petanjek et al., 2011).
The Salk researchers, which include co-first authors Mo Li and Keiichiro Suzuki, both research associates in Belmonte's
laboratory, set
out to devise a safe method to use iPSCs to correct the HBB
gene in patients who have defective copies
of the
gene.