Sentences with phrase «gene pathways in»

Preventing Cancer Sulforaphane - filled broccoli sprouts, in oral and topical form, are shown by Kimmel Cancer Center investigators to reactivate a cancer - preventing gene pathway in breast, lung, stomach, and skin cancers.

Not exact matches

In many animal model systems, for example, the precise genes involved in sexual partner selection have been identified, and their neuro - biochemical pathways have been worked out in great detaiIn many animal model systems, for example, the precise genes involved in sexual partner selection have been identified, and their neuro - biochemical pathways have been worked out in great detaiin sexual partner selection have been identified, and their neuro - biochemical pathways have been worked out in great detaiin great detail.

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

Xie et al. report that STING (stimulator of interferon genes)-- the main adaptor in several DNA - sensing pathways — is mutated in bats at the serine - 358 residue, which is critical for downstream interferon (IFN) activation.

In McGlinn's mutant mouse, the disrupted pattern - forming genes belonged to the molecular signaling pathway named Sonic hedgehog.

Researchers don't think there's a single pathway or gene in a prey bacterium that the predator targets.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manneIn all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent mannein a concentration - dependent manner.

Although unique genetic variations in children with autism are nearly as rare as they are in the general population, comprehensive studies are starting to find patterns in disrupted genes and pathways

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

Susceptibility genes for diabetes may be involved in several different metabolic pathways in the body, including storage and release of fat for energy.

Huntington's monkeys also show levels of inflammatory markers (cytokines and inflammatory pathway genes) in their blood that is greater than in controls.

It was deep in the TGF — beta signaling pathway in a gene involved with uvula development.

Chung and Felton then investigated expression of genes in the anti-herbivore pathway and the production of enzymes.

Up to 15 percent of people's genes are regulated by the day - night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

«By observing neuronal gene expression in these distinct pathways during development, we detected common patterns, as if an underlying genetic language was bringing them together.»

Fruit flies with the mutant form of LRRK2 also had a disrupted microRNA pathway associated with the gene, and accumulated toxic proteins that killed motor - coordinating neurons in the brain.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

Cobbling together the genes of three different species, chemical engineer Jay Keasling (Discover's 2006 Scientist of the Year) of the University of California at Berkeley transformed a metabolic pathway in yeast that allows the engineered microbe to produce a precursor to artemisinin, a compound used to treat malaria.

«In 2010, we unsuccessfully tried testing genes involved in detoxification and concluded that variants in detoxification genes and pathways are less important than previously thought,» says the center's director, Sine Skovbjerg JakobseIn 2010, we unsuccessfully tried testing genes involved in detoxification and concluded that variants in detoxification genes and pathways are less important than previously thought,» says the center's director, Sine Skovbjerg Jakobsein detoxification and concluded that variants in detoxification genes and pathways are less important than previously thought,» says the center's director, Sine Skovbjerg Jakobsein detoxification genes and pathways are less important than previously thought,» says the center's director, Sine Skovbjerg Jakobsen.

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

They have also used state - of - the - art information about brain development to accurately pinpoint new genes and biological pathways implicated in this disorder.

Further tweaks to regulatory genes in the worm's metabolic pathways have upped its life span sixfold.

They found numerous genes activated in the XYL regulon - controlled yeast that upregulated pathways involved in growth, such as cell wall maintenance, cell division, mitochondrial biogenesis and adenosine triphosphate (ATP) production.

Scientists from the Biogerontology Research Foundation (BGRF), a UK - based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data.

Genes with increased activity are in metabolic pathways that allowed cancer cells to bypass BRAF altogether and continue to grow and divide.

And the mutation that bestows such remarkable longevity is a gene that happens to regulate activity in the insulin / IGF signaling pathway, says Robert Schmookler - Reis of the University of Arkansas, a molecular geneticist who discovered the relationship between the mutation and the superworm's extraordinary life.

Once the whittling was complete, the researchers reordered the remaining genes, aligning ones that work in common pathways.

Participants who lacked two genes involved in a genetic pathway that helps the antioxidant glutathione remove carcinogens and toxicants from the body saw an even bigger benefit to taking the watercress extract, which increased their detoxification of benzene by 95.4 percent, acrolein by 32.7 percent and crotonaldehyde by 29.8 percent.

Two years into her research on a mouse - model study of a gene pathway's role in the immune system, she joined UCB Celltech.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

«However, recent work has shown that at least some of the fungal partners in arbuscular mycorrhizal symbioses lack the genes for enzymes involved in the major pathway of lipid biosynthesis, and are therefore unable to produce certain essential fatty acids,» Gutjahr explains.

Many of the genes identified by Dr. Papapanou and his team are implicated in immune and inflammatory pathways, confirming laboratory and clinical observations of the development of periodontal disease.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

Understanding these defective genes and pathways in each individual will help tailor treatments.»

And 40 genes involved in these nine schizophrenia - related pathways also differed much more between chimps and humans than genes associated with the other 12.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Both findings suggest that different types of autism may share a common pathway even when they occur in distinct syndromes or alone — something that wasn't clear just from looking at the genes.

«Signaling pathways and gene expression profiles are very different in cells that grow in 2D and 3D cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.

Dias and Ressler probed the Notch pathway because they were examining many genes that are activated in the brains of mice after they learn to become afraid of a sound paired with a mild foot - shock.

One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.

Understanding the role of the microbes that live in the gut and help process nutrients not only promises a fuller understanding of the link between genes, diet and disease, but may also be a pathway to pinpointing the genes responsible for conditions like diabetes.

But BRCA is just one of the many genes that encode important proteins in the DNA repair pathway known as homologous recombination,» says the study's lead author, Arielle Heeke, MD, a clinical fellow at Georgetown Lombardi Comprehensive Cancer Center.

The gene expression similarities between this common condition and the current findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD

«This is an exciting study of a very rare bone disorder that not only identified the responsible mutation in half of the patients, but uncovered fundamental information about the role of a cancer - related gene in the metabolic pathways of normal bone,» said study co-senior author Joan Marini, Ph.D., M.D., of NICHD.

By understanding the genes and pathways involved in the immune response, we may be able to interpret the signals that determine whether an organism decides it is beyond repair or tries to regenerate.