Sentences with phrase «gene polymorphisms on»

Research Paper The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta - Analysis Le Du, Lei Lei, Xiaojuan Zhao, Hongjuan He, Erfei Chen, Jing Dong, Yuan Zeng, Jin Yang J. Cancer 2018; 9 (8): 1506 - 1517.

The impact of common dopamine D2 receptor gene polymorphisms on D2 / 3 receptor availability: C957T as a key determinant in putamen and ventral striatum.

Not exact matches

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Rather than measuring genetic changes directly (such as single nucleotide polymorphisms, otherwise known as SNPs), McKee and her group typically do RNA expression profiles on patients to see what genes are being expressed.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Every gene was assigned a score, based on previous studies, where 0 indicated that the polymorphism of this gene did not create a muscular advantage for running a marathon, 1 meant a standard level and 2 indicated that the polymorphism of the gene conferred positive properties for bearing this effort through muscles.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Analysis of a linkage peak on chromosome 13 with a dense set of SNPs (single nucleotide polymorphisms) revealed a four - SNP haplotype spanning the gene encoding FLAP (ALOX5AP) that confers an approximately twofold increased risk of myocardial infarction, or heart attack.

The alliance will employ Illumina's platform for high - multiplex single - nucleotide polymorphism (SNP) genotyping to develop tests for gene variants deCODE has previously shown to have impact on the risk of a growing number of common diseases with major public health impact.

SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene.

Many million different users consult these databases each year, seeking information on anything from DNA sequences, protein structures, gene expression profiles, human genetic polymorphism or even comparative analyses of entire genomes.

Furthermore, as dopaminergic mechanisms modulate pain responses, these researchers assessed the influence of the functional DRD2 gene polymorphism (957C > T) and the catechol - O - methyl - transferase (COMT) Val158Met polymorphism on the analgesic effect of rTMS.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

As they pointed out, the repeat occurs in a region of DRD4 associated with gene activity, so the 120/240 polymorphism may have a functional effect on the dopamine receptor.

On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Polymorphisms in five of 15 genes (33 %) encoding molecules known to primarily influence pancreatic beta - cell function - ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)- significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.

The human DAO gene spans ≈ 10 kbp and is located on chromosome 7q35 (27) Various single - nucleotide polymorphisms (SNPs) in the DAO gene have been shown to be associated with inflammatory and neoplastic gastrointestinal diseases, such as food allergy (44), gluten - sensitive enteropathy, Crohn disease, ulcerative colitis, and colon adenoma (45 — 47).

The study suggests that oxytocin receptor gene polymorphisms have an impact on proximity to unfamiliar humans and on how friendly the dogs were toward the human.

A factor analysis based on descriptors of 81 Labrador retrievers being trained as guide dogs found that polymorphisms in two genes — comt and the glutamate receptor (slc1a2)-- significantly related to a principal component described as «activity».

Even though significant gene × gene interactions have not been extended to an antisocial behavioral phenotype, a number of lines of research converge to show that dopaminergic polymorphisms have independent effects on a wide array of maladaptive and antisocial phenotypes, such as compulsive gambling, alcohol consumption, and antisocial personality traits [3, 17 — 19].

Adults who had been categorized as behaviorally inhibited at the age of 2 years exhibited a higher amygdala activation in response to unknown vs familiar faces16 compared with adults who were uninhibited as children, consistent with the notion that novel or ambiguous environmental stimuli of potential biological relevance activate the amygdala.17 Turning to genes that can influence the neurobiological bases of the processing of emotions, 2 common alleles, the short (S) and the long (L), in a variable repeat sequence of the serotonin transporter (5 - HTT) promoter polymorphism (5 - HTTLPR) on human chromosome 17q11 have been differently associated with greater amygdala activity in response to angry or fearful faces18 in healthy adults.

Functional activity of the MAOA gene promoter polymorphism was determined and genotypes scored for assessing genetic and environmental influences on aggression.

Related to this question, recent research suggests that particular polymorphisms, often those linked to risk for pathology, make the individual more susceptible to be influenced by parenting and other experiences.24 - 26 For example, children carrying the 7 - repeat variation of the DRD4 appear to benefit more from interventions directed to prevent behaviour problems than those carrying other variations of the gene.24 Nonetheless, further research is needed on how and to what extent EC skills may be influenced by the interplay between constitution and experience.

The moderating effects of three single nucleotide polymorphisms (SNPs)(rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task.

Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African - American Adolescent Alcohol Abuse.