Sentences with phrase «gene products»

Final confirmation would depend on studies of the effects of the mutation of the expression of gene products at the levels of RNA and protein.

As a result, patents on human gene products allowed in some European countries may be banned in others.

Today, science has evolved to the mapping of gene families, and to the systematic determination of the interactions between gene products.

Similarly, the particular gene products that may result from cap - independent translation have yet to be identified and characterized.

RNA editing, which can alter gene products without making changes to the genome, has profound potential as a tool for both research and disease treatment.

The 4,000 missing gene products needed for bacterial growth can be supplied by wet, warm human tissue.

This RNA primer will not later be replaced by DNA, and therefore can not be translated into gene products or replicated later.

For many genetic disorders, the disease results from the expression of a defective gene product, not the complete absence of the product.

Information obtained from genetic models provides crucial information for a given gene product and helps determine their validity in clinical applications.

Since then, so - called Omics technologies have flourished, allowing researchers, for example, to observe and quantify thousands of gene products in a single tissue sample.

In his talk, Wieland Huttner, a molecular cell biologist and developmental neurobiologist at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) in Dresden, Germany, explained how his team searched databases for proteins and other gene products expressed in the human brain in these earliest phases of development.

One common trait among these genomes was the presence of gene products involved in Quorum Quenching, such as AHL acylases and Homoserine dehydrogenases.

It is likely that previously uncharacterized gene products with intriguing effects on behavior will be discovered within these networks.

The preclinical models are also used for trialling novel anti-metastatic agents targeting gene products found to drive metastasis.

Some other gene products for treatment of CLI have failed in the late phases of clinical trials (for example,

«Co-expression of alternative gene products helps neurons take shape.»

Recent work indicates that individual T lymphocytes possess receptors that interact with both thymus - dependent antigens and MHC gene products, either independently or as associated structures.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

The Nishikura laboratory explores the phenomenon of RNA editing, which regulates expression of certain gene products by changing the sequence context of mRNAs.

Regulation of Gene Expression (Jason Mills and Andy Greene, co-Section Editors): This section focuses on manuscripts that use existing or novel high - throughput technologies to study, at the systems level, how gene products (RNA, protein) change in abundance during pathophysiology and / or development.

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.

Nusinersen and similar compounds being developed for spinal muscular atrophy focus on increasing or making more of the SMN gene product that gets converted into usable protein.

Then, researchers then sought a way to increase SMA gene product levels, the messenger RNAs (mRNAs), and thus protein levels by silencing or removing the SMN lnc - RNA.

When human YME1L1 was introduced into yeast with the mutated YME1, the human gene product partially rescued the YME1 mutation, preventing migration of mitochondrial DNA into the nucleus.

«Another important aspect of our study is that, at least for some genes, co-expression of alternative gene products appears to be an actively regulated process rather than being simply a result of «splicing noise.»

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.

SGI - 110 is a novel next generation small molecule drug which inhibits DNA methylation — one of several epigenetic mechanisms that cells use to control gene expression, the process by which genetic instructions are used to synthesize gene products.

Chitosan protects the therapeutic gene product and chaperones it through the gut.

They comprise a little - explored realm of fungi, providing a repertoire of important and valuable gene products for DOE missions in bioenergy and environment.

In August Japanese scientists reported yet another method for making «personalized» cells without cloning: They treated mouse skin cells with four gene products active in embryonic stem cells and got the skin cells to revert to something much like the stem cells.

The signal induces the expression of many innate immune and antiviral genes and the production of antiviral gene products, pro-inflammatory cytokines, chemokines and interferons.

The problem chiefly involves antibodies, a class of proteins scientists have used for generations for everything from quantifying receptor expression to purifying critical gene products.

They found that minor allele carriers had less IL - 28B gene product activation stronger antibody immune response to influenza vaccination.

The researchers also note that many neuropsychiatric and neurological diseases are associated with chronic alterations of specific gene products in neurons.

The RNA structure also functions as a temperature sensor when introduced into bacteria other than Listeria, making it useful as a tool to manipulate gene products, they report in the 6 September issue of Cell.

Melton and colleagues are now doing large scale screening with microarrays to track gene activity as cells develop and discover gene products that move cells along the proper paths.

«We may have discovered a major step toward developing a «dream tool» for remotely controlling neural circuits, by manipulating specific cells using engineered gene products that respond to magnets,» said Ali Deniz Güler, a UVA biology professor who led the study in his neuroscience lab.

Very soon after fertilization, the control of embryonic development shifts from pre-existing maternal gene products to the products of genes encoded by the early embryo (or zygote).

«Type III» cells of rat taste buds: Immunohistochemical and ultrastructural studies of neuron - specific enolase, protein gene product 9.5, and serotonin

Analysis of multiple gap junction gene products in the rodent and human mammary gland.

The Viral MetaGenome Annotation Pipeline (VMGAP) pipeline takes advantage of a number of specialized databases, such as collections of mobile genetic elements and environmental metagenomes to improve the classification and functional prediction of viral gene products.

This led us to suspect that anti-apoptotic gene products may lead to the general resistance of the mesenchymal cells.

Members of a family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance gene products.

The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6 - dependent mechanism.

Moreover, the proapoptotic gene products BBC3 / Puma and BCL2L11 / Bim were downregulated in mesenchymal cells, possibly contributing further to their enhanced survival.

Evaluation and validation of candidate gene products entail elucidation of their functional networks and mechanisms of action.

In female mammals, one of the two X chromosomes is transcriptionally silenced during early development to compensate for the double «dose» of X-linked gene products in females -LSB-...]