The preclinical models are also used for trialling novel anti-metastatic agents targeting
gene products found to drive metastasis.
Markowitz and University of Kentucky Professor Hsin - Hsiung Tai earlier had demonstrated that
a gene product found in all humans, 15 - hydroxyprostaglandin dehydrogenase (15 - PGDH), degrades and reduces the amount of PGE2 in the body.
Not exact matches
She is identifying the enzymes in these natural
products to
find the
genes responsible so that they can be introduced into other plants.
This cDNA lacks the non-coding «introns»
found in the full sequence of a
gene and is therefore not a
product of nature — which is why the court ruled that it can be patented.
High in the Cederberg Mountains of South Africa grows a bristly shrub that embodies the tug - of - war taking place between industrialized and developing nations over the value of genetic resources — the
genes found in plant, animal or microbial cells used for research as well as in commercial
products, such as enhanced seeds and naturally derived cosmetics and pharmaceuticals.
They
found that Paroxetine caused increased production of the
gene ITGB3 — whose protein
product is thought to interact with CHL1 to promote the development of new neurons and synapses.
They
found that minor allele carriers had less IL - 28B
gene product activation stronger antibody immune response to influenza vaccination.
Kuruvilla's lab group — which has been studying the peripheral nervous system for years —
found that abundance of a particular
gene product in Down syndrome puts a brake on NGF's actions in fostering nerve development.
Instead he
found a genome - wide divide, with some
genes churning out a staggering 300 percent more of their
product, depending on whether they were in males or females.
It will potentially eliminate the need to sequence around a newly discovered disease SNP to
find the variant that actually alters the
gene product, says NHGRI Director Francis Collins.
Taken together, these
findings support the idea of a global functional relatedness for disease
genes and their
products, and offer a network ‐ based model for the disease propensity in an individual (Goh et al, in press).
Aiming ultimately to make healthier beef, eggs, and other farm
products, scientists have used a worm
gene to genetically engineer mice whose tissues are unusually rich in the heart - healthy fats
found mainly in fish.
The
finding has implications for drug development, Moxon points out, because a drug targeted at a
gene's
product will not be of much use if the
gene is frequently switched on and off.
How can a mutant
gene whose
product is
found in every cell only sicken certain brain cells?
In one, he
found elevated expression levels of the
gene MSH2, whose
product is a known DNA repair enzyme.
People with this
gene should also avoid synthetic folic acid which is
found in prenatals, multis, B vitamins and even more ubiquitously in fortified foods like white flour, pasta, breads, nutrition bars as well as a lot of gluten free
products.
The
product of the MDR1
gene, P - glycoprotein, is a large ATP - dependent transmembrane protein transporter
found in the blood - brain barrier among other tissues.22 P - glycoprotein pumps substrates (e.g. ivermectin and loperamide) within the brain back into the blood.