Sentences with phrase «gene profiling studies»

Not exact matches

«Researchers have done metabolic studies in patients with adrenal cancer, but they have looked at larger molecules, and they have targeted their investigations at specific steroids or gene profiles.

Lead author Johan den Boon, associate scientist with the Morgridge Institute for Research at the University of Wisconsin - Madison, says the research team used gene expression profiling on 128 specimens from the Study to Understand Cervical Cancer Early Endpoints and Determinants, or SUCCEED.

«This is the first study to offer an unbiased profile of novel imprinted genes in a mammal other than mice,» said lead author Xu Wang, a postdoctoral associate in the laboratory of Andrew Clark, professor of molecular biology and genetics and the study's senior author.

The three - year study included cell culture studies at Rice as well as a detailed analysis of gene - expression profiles of more than 500 patients from the Cancer Genome Atlas and protein - expression profiles from about 200 MD Anderson patients.

In profiling gene expression in the 128 specimens, the study posed the question: What other genes might be behaving like p16?

«These findings raise the possibility that by determining the gene expression profile of a patient's tumor, physicians may be able to identify aggressive disease at the outset of diagnosis and start treatment earlier,» said Sungyong You, PhD, an instructor in the Cedars - Sinai Department of Surgery and the first author of the study.

The team used gene expression profiling and found that canine B - cell lymphoma expression profiles were similar in many ways to human B - cell lymphoma, thus paving the way for future studies, including therapeutic clinical trials in dogs and humans.

Pharmacogenomics — the study of how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic profiles.

«It has taken us years to assemble the clinical outcome database and tissue samples, generate the immunohistochemical biomarkers, gene expression profiles and analyse the data for this study — and we were delighted to find a definite link between alpha beta crystallin and breast cancer progression, which we hope will ultimately improve clinical outcomes.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

Oncologists welcome gene expression profiling tests as an added tool in deciding whether women with early - stage breast cancer should have chemotherapy, a new study has found.

Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor.

Hormone ‐ replacement therapy influences gene expression profiles and is associated with breast ‐ cancer prognosis: a cohort study

Our guest published a historic paper less than one month ago (available here), describing the first comprehensive study of an individual, combining genomic (genome sequence), transcriptomic (genes turned on / off), proteomic (the total complement of proteins - or protein profiles), metabolomic (complete metabolic analysis), and autoantibody profiles.

The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.

We study microRNA function by profiling these regulators and their gene targets in the single cells where the interactions between them occur.

In this study we have explored the gene expression profile and signaling pathways followed by the calcification process of a basal metazoan, the Red Sea scleractinian (stony) coral, Stylophora pistillata.

8/27/2008 First Gene Associated with Dry Macular Degeneration Found Findings indicate possible adverse consequences to new RNA therapies In a study that underscores the important role that individual genetic profiles will play in the development of new therapies for disease, a multi-institutional research team — led... More...

Genomes that have been sequenced as part of a GWAS can be run through PrediXcan to generate a gene expression level profile, which is then analyzed to determine the association between gene expression levels and the disease states or the trait of interest being studied.

As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.

Previous studies have linked gene expression profiles in bCSCs with a clinical outcome [1, 2], and in this study the authors have extended this out to demonstrate that a DNA methylation profile may promote these changes, and furthermore, that this profile can be effectively used to predict prognosis, and potentially aid the therapeutic decision making.

It is noteworthy that this is the first study to show the gene expression profiles of human parthenogenic embryos at any stage.

Some of the first high - profile disease gene studies therefore used dbSNP as a filter.

For this study, Encode will isolate peripheral blood mononuclear cells from patients and generate gene expression profiles of cells through in vitro exposure to the candidate drug.

Understanding the metabolism and gene expression profiles as well as inter-species interactions within these complex microbial communities are necessary steps in studying the diseases and finding new treatment solutions.

Performs genome - wide profiling of vector integration sites as readout of cell growth at clonal level, in basic research studies and technology development, in preclinical safety studies and in gene therapy treated patients.

The aim of this study was to evaluate the correlation between antimicrobial resistance (AMR) profiles of 96 clinical isolates of Actinobacillus pleuropneumoniae, an important porcine respiratory pathogen, and the identification of AMR genes in whole genome sequence (wgs) data.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Using the two link buttons on the left, it is possible to further study the gene list of a particular «wave» in the context of publicly available databases, or view the gene expression profiles in ExpressView.

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

Angola and South African Giraffes can be uniquely identified by their maternal gene profile For the study, the researchers created a profile of the subspecies» mitochondrial DNA, using tissue samples from about 160 giraffes from various populations across the entire African continent.

A systems biology approach integrating genome ‐ wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control.

Muscle biopsies from the study showed «a remarkable reversal of the expression profile of 179 genes associated with age and exercise training... Genes that were down - regulated with age were correspondingly up - regulated with exercise, while genes that were up - regulated with age, were down - regulated with exercise.&rgenes associated with age and exercise training... Genes that were down - regulated with age were correspondingly up - regulated with exercise, while genes that were up - regulated with age, were down - regulated with exercise.&rGenes that were down - regulated with age were correspondingly up - regulated with exercise, while genes that were up - regulated with age, were down - regulated with exercise.&rgenes that were up - regulated with age, were down - regulated with exercise.»

In this study, we have shown the gene expression profile in human adipocytes treated with anthocyanins (cyanidin 3 - glucoside; C3G or cyanidin; Cy).

In this study, we have shown for the first time the gene expression profile in isolated rat adipocytes treated with anthocyanins (cyanidin 3 - glucoside; C3G or cyanidin; Cy).

The study also aimed to see if they could predict who would do best on low carb or low fat by testing their insulin levels and gene profile before the start of the study.

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.

For example, in a study of the long - term impact of the Fast Track programme in the USA for children with behavioural problems, children with a particular genetic profile (those with a variant in the glucocorticoid receptor gene) were the ones who both benefitted the most from the intervention and the ones in the control group who did the worse when no intervention was provided (Albert et al., 2015).