Sentences with phrase «gene promoters»

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.

Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic - hypothalamic - pituitary - adrenal axis regulation in monkeys.

Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic - hypothalamic - pituitary - adrenal axis regulation in monkeys.

Maternal mental well - being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate.

Besides, some other potential cis - acting elements for transcription factors [such as CAAT / enhancer binding protein (C / EBP) and PU.1] have been also noted in the RIG - G gene promoter.

Association study of a monoamine oxidase A gene promoter polymorphism with major depressive disorder and antidepressant response

Epigenetic gene promoter methylation at birth is associated with child's later adiposity.

We also thank James Nagle and Debbie Kauffman, from the NINDS DNA sequencing core facility, for excellent technical assistance with sequencing the serotonin transporter gene promoter as part of a «large sequencing project» granted to J.R.W.; and Dr Scott R. Whittemore, University of Louisville, for providing us with the RN46A cell line.

We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects.

Gene promoters more methylated in CPA have higher CpG density than the average CpG content of all promoters analyzed (p < 6.3E - 27).

In all, we found 900 probes from 448 distinct gene promoters whose normalized intensities were significantly associated with chronic aggressive behavior (FDR < 0.2, Spreadsheet 1).

Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII - I.

(10) To generate mice in which p16Ink4a - expressing cells could be similarly selectively ablated, van Deursen's team substituted a fragment of the p16Ink4a gene promoter for the Fabp4 promoter, thereby generating BubR1H / H; INK - ATTAC mice.

However, epigenetic changes at a single gene promoter are unlikely to account for the range of outcomes and the persistent change in expression of hundreds of additional genes in adult rats in response to differences in maternal care.

More than 60 % of the genes analyzed by the microarray have inversely correlated promoter DNA methylation and expression levels (defined as gene promoters with methylation above 50 % and expression below the 50 - percentile of expression levels, and vice versa).

In amyloid - beta - overproducing Alzheimer's mice, researchers found that the frequency of HSF1 binding to the TTR gene promoter was doubled in the Alzheimer's mice compared to ordinary mice.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Here, we present evidence of widespread divergent transcription at protein - encoding gene promoters.

The locus - specific origin of for mature miR -124-3p was identified at a site on chromosome 3, out of three possible chromosomal sites, and two CpG «islands» that can act as sites from epigenetic modification by DNA methylation were identified near the miR - 124 gene promoter on chromosome 3.

Just as engineers rearrange capacitors and resistors to create different electric circuits, researchers can arrange gene promoters and repressors — stretches of DNA that control gene activity — to create gene circuits with different properties.

PARTICLE acts in three different ways to prevent expression of the MAT2A gene: 1) by winding around the MAT2A gene to create a DNA: RNA triple helix structure locking down the MAT2A gene promoter, 2) by binding the messenger RNA product of the MAT2A gene and preventing it being used for MAT2A protein synthesis and 3) transferring MAT2A messenger RNA into intracellular vesicles that are subsequently ejected from the cell.

A zinc - finger transcriptional activator designed to interact with the γ - globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.

We show different gene promoter sensitivities may make substantial changes to patterns of consolidation.

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

The short form of the serotonin transporter gene promoter does not explain autism, insists Dr. Cook, who heads a nationwide consortium of researchers looking for the genetic underpinnings of this disease, but it does appear to play a significant role, perhaps in concert with other abnormalities which we've not yet uncovered.

Peak finding and annotation to the nearest RefSeq gene promoter was performed using HOMER (findPeaks program using the «- style factor» option).

The data indicate that the epigenetic response to maternal care involves not only single candidate gene promoters but includes transcriptional and intragenic sequences, as well as those residing distantly from transcription start sites.

Also to explore in women with BN the extent to which methylation of the GR gene promoter corresponds to childhood abuse, suicidality, or borderline personality disorder (BPD).

Q - MeDIP analysis of DNA methylation differences between CPA (black) and control (white) groups in men and women T cells samples for four gene promoters predicted to be more methylated in the men CPA group by microarray analysis.

When applying a more stringent criteria to our list of differentially methylated promoters, such as FDR < 0.05, 184 probes located within 60 gene promoters remained significantly associated with CPA (Spreadsheet S1).

Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder

D, IRF - 9 — deficient U2A cells were transiently transfected with IRF - 1 or empty vector, the binding of exogenous IRF - 1 to RIG - G gene promoter was tested by ChIP assay, and the induction of reporter gene pXP2 (− 310) was detected with luciferase assay.

Early life adversity and serotonin transporter gene variation affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain

Younger ST, Corey DR. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.

Functional activity of the MAOA gene promoter polymorphism was determined and genotypes scored for assessing genetic and environmental influences on aggression.

Gene promoters more methylated in CPA have also higher CpG density than the promoters less methylated in CPA (p < 1.3E - 33; Wilcoxon rank - sum test).

In total, 448 distinct gene promoters were differentially methylated in CPA.

Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders

Specifically, while 5mC is found at repetitive regions of the genome, the methylated adenines were clustered into dense «methylated adenine clusters» (MACs) at gene promoters.

Methylation of the glucocorticoid receptor gene promoter in bulimic women: Associations with borderline personality disorder, suicidality, and exposure to childhood abuse

Importantly, we have recently shown that differential DNA methylation of the serotonin transporter gene promoter (SLC6A4) in T cells and monocytes is associated with in vivo measures of human brain serotonin synthesis and childhood limited physical aggression in men [46].