Sentences with phrase «gene rearrangements»
"Gene rearrangements" refer to changes in the arrangement or order of specific sections of DNA within a gene. It happens when parts of genes are rearranged, deleted, or duplicated. These changes can potentially affect the functioning of the gene and lead to various genetic conditions or diseases. Full definition
Analysis of Immunoglobulin and T Cell Receptor Gene Rearrangement in the Bone Marrow of Lymphoid neoplasia Using BIOMED - 2 Multiplex Polymerase Chain Reaction.
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They then looked for DNA breaks associated with receptor gene rearrangement by using a version of the polymerase chain reaction that amplifies broken DNA.
We work with European colleagues towards standardization of molecular diagnostic testing for gene rearrangements and gene translocations, including an alliance with the EuroClonality / BIOMED - 2 Group around their outstanding work towards standardized clonality testing.
Detection of immunoglobulin heavy chain gene rearrangements in classic hodgkin lymphoma using commercially available BIOMED - 2 primers.
In 6 cases, Ig / TCR gene rearrangement test did not detect BM involvement, which was presented by microscopy.
Detection of Clonal T - Cell Receptor Beta and Gamma Chain Gene Rearrangement by Polymerase Chain Reaction and Capillary Gel Electrophoresis.
Dorothy Romanus, lead author of the study, states «this analysis supports the value of multiplexed testing for EGFR and ALK gene rearrangements followed by molecularly - guided therapy in decisions surrounding coverage of related testing and targeted therapy.
Our NGS kits are used to detect clonal gene rearrangements, somatic hypermutations and for the study of MRD.
Invivoscribe BIOMED - 2 Primer Mixes in B - Cell Immunoglobulin Gene Rearrangement Studies: Experience of a Molecular Diagnostics Laboratory in a Major Tertiary Care Center.
Duration of Symptoms Does Not Correlate with Results of T - cell Gene Rearrangement Studies in Patients Evaluated for Cutaneous T - Cell Lymphoma.
In 5 % (6/119) of B cell neoplasias, the BM involvements were detected by microscopic evaluation, but Ig gene rearrangements were negative.
A number of Invivoscribe LymphoTrack Assays, formatted for use on both the Illumina MiSeq ® and Thermo Fisher Ion PGM ™ platforms, were designed to detect somatic gene rearrangements within the antigen receptor loci.
Alexander Drilon, MD, Assistant Attending Physician in the Developmental Therapeutics Clinic and the Thoracic Oncology Service, will report results from the international phase I STARTRK - 1 and STARTRK - 2 clinical trials, which assessed entrectinib as a treatment for patients with advanced solid tumors harboring gene rearrangements and of which he is principal investigator at MSK.
In fact, somatic ETV6 translocation is the most common gene rearrangement in childhood leukemia.
«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»
But the explanation also posed a puzzle: Those random gene rearrangements also produce T cells that could attack the body's own tissues.
• Testing revealed an ALK gene rearrangement when a sample of a patient's uterine leiomyosarcoma was profiled.
Our bioinformatics team has expertly designed and validated software that can detect mutations or gene rearrangement sequences (clonotypes) at sensitivities as low as 10 - 4 (or even down to 10 - 6 if sufficient DNA input is available).
Diagnostic Value of Immunoglobulin κ Light Chain Gene Rearrangement Analysis in B - Cell Lymphomas.
Several ongoing projects include the identification of newly discovered gene rearrangements in rare and refractory (unresponsive or resistant to therapy) tumors from patients evaluated at the Rutgers Cancer Institute of New Jersey.
Several gene rearrangements have been engineered and their protein products have been expressed in both normal cells and cancer cells to understand the effects of each rearrangement on cell function and targeted drug effectiveness.
Mitochondrial gene rearrangements confirm the parallel evolution of the crab - like form.
As a reagent manufacturer, we offer a comprehensive selection of gel, capillary, and next - generation sequencing PCR assays for gene rearrangement, chromosome translocation, and gene mutation detection as analyte specific reagents (United States), research use only, or CE - marked in vitro diagnostics to laboratories (outside of North America).
Three Hodgkin's diseases were enrolled whose BM involvement was revealed by microscopy and 2 of them revealed TCR gene rearrangement.
Tests that detect TRB clonal rearrangements are useful in the study of T - cell malignancies as leukemias and lymphomas generally share one or more cell - specific or «clonal» antigen receptor gene rearrangement (s).
Molecular pathology diagnosis of diffuse large B cell lymphoma using BIOMED - 2 clonal gene rearrangements
Ritchie KA, Brinster RL, Storb U. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in k transgenic mice.
Among the 119 B cell neoplasias, microscopic BM involvement was positive in 31 cases and Ig gene rearrangement was detected in 25 of 31.
During development, the antigen receptor genes in lymphoid cells undergo somatic gene rearrangement (Tonegawa S. et al., 1983).
About 4 percent of NSCLCs are driven by genetic aberrations called ALK gene rearrangements, according to Farace.
Detection of Clonal Immunoglobulin Heavy Chain Gene Rearrangements by the Polymerase Chain Reaction and Capillary Gel Electrophoresis.
The drug is an oral compound that inhibits the activity of ALK, which, when engaged through a gene rearrangement can drive the growth and survival of the cancer.
Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.
The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.
In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z / 3 cell line a kappa light chain rearrangement probably occurred.
MRD was assessed using polymerase chain reaction analysis of Ig / TCR gene rearrangements.
Among the 29 T cell neoplasias, microscopic BM involvement was positive in 6 cases and TCR gene rearrangement was detected in all of them.
They also include a comprehensive bioinformatics package, enabling you to identify the DNA sequence, clonal prevalence, and V - J family identity for each gene rearrangement.
With our NGS - based assays, the gene rearrangement status of several million lymphocytes in blood, bone marrow, or tissue samples can be both identified and characterized.
Since leukemias and lymphomas originate from the malignant transformation of individual lymphoid cells, all leukemias and lymphomas generally share one or more cell - specific or «clonal» antigen receptor gene rearrangements.
This LymphoTrack TRB Assay — MiSeq ® represents a significant improvement over existing clonality assays using fragment analysis as it efficiently detects the majority of TRB gene rearrangements using a single multiplex master mix, and at the same time, identifies the DNA sequence specific for each clonal gene rearrangement.
The presence of clonality is determined by looking at the distribution of B - and T - cell receptor gene rearrangements.
This assay will increase the probability of identifying T cell receptor beta chain gene rearrangements versus when testing for TRG gene rearrangements only.
A comprehensive bioinformatics software package is provided free of charge with purchase; enabling you to identify the DNA sequence, clonal prevalence, V - J family identity for each gene rearrangement, and with the IGH FR1 assay, the extent of IGHV somatic hypermutation (SHM).
They also include a comprehensive bioinformatics package, enabling you to identify the DNA sequence, clonal prevalence, and V - J family identity for each gene rearrangement, as well as the extent of IGHV somatic hypermutation (SHM) for IGH FR and IGH Leader.
PCR - and NGS - based cell clonality testing analyzes the distribution of immunoglobulin and T - cell receptor gene rearrangements to accurately detect the presence of a clonal cell population.
The laboratories also offer highly sensitive NGS - based MRD assays to track FLT3 mutations and patient - specific immunoglobulin and T - cell receptor gene rearrangements.
These comprehensive assays are capable of detecting single nucleotide substitutions, insertions, deletions and gene rearrangements.