Sentences with phrase «gene region contains»

The scientists removed the gene region containing the risk variant from the mouse genome, and found that as a result the mice were healthy but displayed a small decrease in the expression of a nearby cancer gene, called MYC.

Not exact matches

GWAS identify regions of the genome that can contain hundreds of genes potentially affected by a mutation.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

In mice, they deleted four ultraconserved elements — individually and in various combinations — that lie within regions of DNA that also contain genes important in brain development.

Last summer, Hamer and his colleagues made worldwide headlines when they announced that a region near the tip of the X chromosome probably contained a gene or genes for homosexuality.

The teams are yet to identify every gene contained within this supergene region, but have so far found a gene involved in colouring, which could explain differences in plumage, as well as genes involved in processing sex hormones.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

The locus most strongly associated with severe CCD was found on chromosome 34 — a region containing three serotonin receptor genes.

Making up 98 percent of the genome, these regions do not code for proteins, but they contain «switches» that like a conductor control when and where genes are expressed.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythm.

And large, genome - wide studies searching for genetic underpinnings for more common diseases, such as lung cancer or autism, have pointed to the nether regions of the genome between the protein - producing genes — areas that were often thought to contain «junk» DNA that was not part of the pantheon of known genes.

Instead, a chromosomal region containing genes involved in neuronal development explained most of the male behavioural response.

However, all regions of the human brain have molecular signatures very similar to those of our primate relatives, yet some regions contain distinctly human patterns of gene activity that mark the brain's evolution and may contribute to our cognitive abilities, a new Yale - led study has found.

This will cover a pilot project in a small region — about 1/1000 of the human genome — containing the genes for the major histocompatibility complex (MHC), proteins that present snippets of pathogens to immune cells.

«Capturing introns: Targeting rapidly evolving regions of the genome for phylogenetics: New protocol for targeting intron - containing genes to resolve evolutionary relationships between closely related species.»

However, further investigation revealed two candidate genomic regions that appeared to be involved, one of which contained the TGBF3 gene.

Using a specialized gene manipulation technique called chromosome engineering, researchers developed genetically engineered mouse strains in three separate iterations: MYC only, the rest of the region containing PVT1 but without MYC and the pairing of MYC with the regional genes.

Bagchi and his team focused on a region of the genome, 8q24, which contains the MYC gene and is commonly expressed in cancer.

And each region could contain several relevant genes.

Consistent with that result, the researchers found that certain regions of the X chromosome in human female B cells, including regions that contain immunity - related genes, were expressed at higher levels than male cells.

Exploring these sequenced BACs that contain an estimated two - thirds of all barley genes, Close and his team found that gene - rich areas are not found only in high combination regions.

These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.

The region may contain one or several «genetic booster rockets,» as Perls describes them, genes that slow aging and decrease susceptibility to all age - related diseases.

Several of the genetic regions contributing to face shape detected by the researchers contain genes known to play a role in facial development and facial abnormalities.

And because researchers break apart and then reassemble the 3 - billion - letter - long genetic instruction book in order to analyze it, sections that have duplicated genes are harder to put in the right order and thus harder to study, which was the case with the region containing the red blood cell protein DNA.

A linkage study identifies only broad regions containing dozens or even hundreds of genes, whereas GWA studies often allow the association of a specific gene with a certain trait in the population.

The fingered region contains between 100 and 300 genes, and Kaye and colleagues wanted to narrow that down.

Instead, a chromosomal region containing genes involved in neuronal development explained most of the male behavioral response.

The mfd gene encodes a protein of 130 kilodaltons and contains the so - called «helicase motifs,» a leucine zipper motif, and regions of sequence similarity to UvrB and RecG proteins.

These markers allowed the group to narrow the suspect region of the chromosome to a 6 - million - base - pair stretch of DNA that turned out to contain a promising gene: the - synuclein gene.

It is important to point out that the region of the 5qll chromosome contains various known genes that play a role in immune response.

Five of these regions contain no protein - coding genes and may thus include structural or regulatory elements.

We report genome - wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high - altitude adaptation.

They found that the associated regions contained numerous candidate genes, among them genes known to affect ear function, language development, memory, bird song and the brain's reward mechanism.

We divided the genomic regions of both genes to create bins of genomic sequence that contained all deleterious mutations regardless of category or function.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

More than 2,000 of the shared regions identified in this study (out of 3,500) do not contain genes.

Researchers from the University of Chicago and the Beijing Institute of Genomics estimate that the tumor, about 3.5 centimeters in diameter, contained more than 100 million distinct mutations within the coding regions of its genes — thousands of times more than expected.

The human T cell receptor beta (TRB, previously known as TCRB) gene locus on chromosome 7 (7q34) includes 65 Vb (variable) gene segments, followed by two separate clusters of genes each containing a Db (diversity) gene, several Jb (joining) genes, and a Cb (constant) region spread over 685 kilobases.

Unfortunately, LOH regions tend to be kilobases or megabases in size, containing dozens or hundreds of genes, and identifying which ones are truly affected in terms of cancer remains challenging.

In addition, the architecture of differentiation is such that these regions were of small size and contained very few genes.

Absence or reduced heterozygosity means that a patient's genome contains long stretches of homozygosity, which can be problematic if that region harbors a variant in an autosomal recessive disease gene.

The modified virus then delivered the new genetic material inside the iPSCs, where the DNA region containing the broken gene was replaced with the sequence containing the normal gene.

Statistical analyses of functional overrepresentation of genes that were contained or partially overlapped differentiated regions were performed using DAVID 6.7 [75].

Adenovirus containing a deletion of the early region 2A gene allows growth of adeno - associated virus with decreased efficiency

Consistent with the variation in size we also found a heterogeneous number of genes contained within each region (ranging from 1 — 31).

However, most differentiated regions contained very few annotated genes: 59 segments (57.8 %) contained three or fewer genes and 30 (29.4 %) localized to a single gene.

Given this pattern, genomic regions that are enriched for fixed differences are likely to be maintained by selection against introgression and thus contain genes involved in hybrid incompatibilities (or loci experiencing selection at linked sites within subspecies; see below).

She is scanning the genomes of individuals in the current study to identify regions that may contain additional gene candidates.

Most differentiated regions were smaller than 200 Kb and contained very few genes.