Sentences with phrase «gene regulation by»

The team first set out to determine which RBPs were critical in RNA - mediated gene regulation by applying an RNAi screen to mESCs.

Not exact matches

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

This finding by Whitehead Institute scientists challenges current understandings of gene regulation via DNA methylation, from development through adulthood.

Today, a team of researchers from the University of Geneva (UNIGE), Switzerland, led by Emmanouil Dermitzakis, Louis - Jeantet Professor at the Faculty of Medicine, reveals that this is not always the case and that DNA methylation may play both a passive and active role in gene regulation.

Of these genes, nearly half that were being suppressed were regulated by estrogen receptor alpha (ESR1), and their down - regulation was noted by the 30 minute mark.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

SpDamID also is uniquely able to identify DNA bound by more than one protein, often a critical step in gene regulation.

«However, genome editing raises a regulatory issue by creating indistinct boundaries in GMO regulations because the advanced genetic engineering can, without introducing new genetic material, make a gene modification which is similar to a naturally occurring mutation.»

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

Without an adequate supply of the S - adenosyl methionine, regulation by histone methylation — and therefore correct gene expression — can not take place.

In cancers, both gene mutations and aberrant regulation of genes (promoter inhibition by methylation of DNA) are known to play pivotal roles regulating cancer growth.

Molecular recognition is fundamental to transcriptional regulation, the primary mechanism by which cells control gene expression.

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

In a study recently published in the journal Neuro - Oncology, a team of scientists led by Luni Emdad, M.B.B.S., Ph.D., and Paul B. Fisher, M.Ph., Ph.D., provided the first evidence of an important link between a specific microRNA, miR - 184, and a cancer promoting gene, SND1, in the regulation of malignant glioma.

A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

Together, we related how biophysical and biochemical properties affected by the SRY mutation relate to the regulation of a gene - regulatory network in a biological system.»

To achieve this, the researchers took advantage of a phenomenon known as quorum sensing, which is used by many species of bacteria to coordinate gene regulation in response to their population density.

It seems to be that we also get a fine - tuned as well as important gene regulation machinery that can be influenced by our environment and individual lifestyle.

But people often reject ideas which don't fit into the bacterial model of gene regulation, which is that genes are turned on and off by proteins binding to DNA.

Instead, viruses mute the immune system by epigenetic regulation — instead of changing the actual code of genes, viruses change the degree to which genes are expressed.

«This study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases, at least psychologically, through regulation of the Ppm1f gene» he adds.

The research that led to these findings is part of a larger effort to better understand gene regulation and expression, carried out by the GTEx Consortium, a National Institutes of Health - funded group that includes researchers from around 80 institutions founded in 2010.

«The discovery that regulation of the Shell gene will enable breeders to boost palm oil yields by nearly one - third is excellent news for the rainforest and its champions worldwide,» says Datuk Dr. Choo Yuen May, the Director General of the Malaysian Palm Oil Board (MPOB), an agency of the Malaysian federal government.

Chromatin is the protein packaging that helps regulate genome function by controlling access to DNA; changes in this packaging can affect gene regulation.

Also, because it is involved in such a critical step in the synthesis pathway, the regulation of the DSYB gene by environmental conditions is of great significance in determining how much DMSP is ultimately produced.»

«Scientists have learned a lot about development, gene regulation, and cancer biology, among other things, by studying C. elegans.

The 28 groups that will eventually make up the CRG will be organised around five main programmes — Gene Regulation, Development and Cell Biology, Cell Differentiation and Cancer, Genes and Diseases, and Bioinformatics and Genomics — each of which will be headed by a senior scientist leading his or her own group.

One of the most cited examples is the mutation involved in lactose tolerance, which is also caused by regulation from outside the gene.

Moreover, the ability to easily program sequence - specific DNA targeting and cleavage by CRISPR - Cas components, as demonstrated for Cas9 and Cpf1, allows for the application of CRISPR - Cas components as highly effective tools for genetic engineering and gene regulation in a wide range of eukaryotes and prokaryotes.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function.

The dedicated tailoring enzymes are encoded by genes clustered with the assembly line genes for coordinated regulation.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple, group interactions that could play a key role in the regulation of genes,» explains Nicodemi.

His development of a method for stable transformation of land plant chloroplast genomes, once thought to be impossible, established the field of chloroplast genome engineering in higher plants and has led to an explosion of research concerning the chloroplast genome's role in photosynthesis, functional analysis of plastid genes by reverse genetics, and mechanisms of plastid gene regulation.

The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to study fundamental processes involved in gene regulation.

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.

His academic research focused on gene regulation and signal transduction mediated by ion channels and G proteins.

BR homeostasis is controlled through transcriptional feedback regulation of these biosynthetic genes by known BR signaling TFs, BRASSINAZOLE RESISTANT1 (BZR1) and BRI1 - EMS - SUPPRESSOR1 (BES1) / BZR2.

We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.

This could be an indication of a controlled expression of genes responsible for calcification during daytime, as evidenced by the up - regulation of genes associated with the cartilage and bone biogenesis process.

Using databases created by other labs, the Duke University scientists cross-checked areas of human DNA that had developed differences from chimp DNA with areas of DNA they expected to be important for gene regulation.

Finally, Yingjie Guan, assistant professor (research) of orthopaedics at Brown and Lifespan, at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

But more importantly this old study (by mitochondrial membrande phospholipid fatty acids composition remodeling towards a low perodizable index PI and double bond unsaturation index DBI by genetically reduced desaturase (essentially switching perodizable polyunsaturates with monounsaturates / saturates, rendering membranes lipid peroxidation resistant / blocking hydroperoxide formation by DHA n - 3 and lowering mitochondrial DNA lesions formation by membrane lipid peroxidation chain propagation), It's true though that these effects are due to transcriptional lipid genes regulation (so the genes are the reason of this dramatic effect and this is also a gene therapy, that hit the key points) this old study showed

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.