Sentences with phrase «gene regulation identified»

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The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

SpDamID also is uniquely able to identify DNA bound by more than one protein, often a critical step in gene regulation.

Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.

Now researchers have identified a mutation in the human ATP4a gene that is involved in the gastric acid secretion regulation and has been identified as responsible of an aggressive form of inherited, early - onset gastric NET.

It now appears that the clocks and clock - related genes — some 20 such genes have been identified — affect virtually all of the cells» metabolic pathways, from blood sugar regulation to cholesterol production.

From the genome wide scan, a set of gene loci correspond to thermostatic regulation has been identified.

After five years of research, they identified the gene regulation pathway, which involves the body's sodium sensor called Nax (scn7a) that triggers inflammation.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

While previous research had identified the presence of feed forward loops in plant gene regulation, «this study increases the scale enormously,» said Bartley.

«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple, group interactions that could play a key role in the regulation of genes,» explains Nicodemi.

We had suspected that the Mycoplasma genome might have a similar overall organisation to other bacteria, but we were completely surprised to find that it was also organised into domains, which can be considered as regulatory units of chromatin organisation and that we had identified a previously unknown layer of gene regulation.

Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes.

We identified and characterized a novel member of the forkhead gene family that is essential for proper regulation of satellite cells.

Fold change of genes identified for regulation of skeletal extension and growth, is presented as treated vs. control during daytime, night - time and without treatment.

Effect of 17β - estradiol and flavonoids on the regulation of expression of newly identified estrogen responsive genes in a rat raphe nuclei - derived cell line.

We also identify genes involved in electrolyte metabolism and homeostasis, including NR3C2, SCPEP1, WNK2, and CACNA1D, with important direct (47, 48) and indirect (49) physiological consequences for blood pressure regulation.

Using drug repurposing, Yoshimura's group not only identified circadian rhythm changing drugs, but also succeeded in identifying genes that are involved in the regulation of the circadian clock.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

It was while he was working on his doctoral project, wing formation in fruit flies, that a discovery made by other investigators in the lab — of the first microRNA (a small RNA important in the regulation of gene expression) identified in the fly — captured his attention and has held it ever since.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

For each such peak, they identified genes within 50 kb as potential targets of regulation.

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

Finally, we will conduct an RNAi based screen to identify novel factors that are involved in the regulation of sestrin gene expression and that may act in conjunction with p53.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

The retinoic acid — induced gene G (RIG - G), also known as IFN - inducible gene 60, was originally identified in all - trans retinoic acid (ATRA)-- treated NB4 acute promyelocytic leukemia (APL) cells (1) and plays an important role in cell growth inhibition through up - regulation of p21 and p27 (2).

In an attempt to identify possible ramifications of gene drives, the National Academy of Sciences has assembled experts to assess current regulations and recommend whether additional oversight is needed.

This observation and the availability of a reference rabbit genome allowed us to identify several candidate genes for reproductive isolation in this system that suggest an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.

268/4: 45 Identifying the transcription factors mediating enhancer — target gene regulation in the human genome.

We have identified common alleles of genes that contribute significantly to both of the principal processes involved in obesity — basic energy metabolism on the one hand and the regulation of appetite on the other,» said Kari Stefansson, CEO of deCODE.

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole - blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources.

Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to certain chemotherapy agents.

For example, the down - regulation of WNT - related genes (WNT7A and WNT11) identified at d 18 may delay the remodeling of the endometrial glands during the window of implantation (44).

In their laboratory they use genomic, genetic and biochemical approach to identify the genes which fall under circadian rhythm regulation in various organs in our body and to delve into what goes on behind that regulation.

Dynamic epigenetic regulations of the Gdnf gene play significant roles in identifying both the susceptibility and the adaptation responses to chronic stressful events.

Microarray identifies extensive down regulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog.