Sentences with phrase «gene regulation system»

This has to do with the fact that most of the genetic damage is confined to the gene regulation system, and does not affect the DNA itself.

Not exact matches

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

The newly unmasked genes play a role in three distinctively different bodily functions, including systems that control inflammation and cholesterol and the regulation of how brain cells clean up toxic proteins.

The systems biologists proposed that — at least sometimes — circRNAs serve gene regulation.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

Together, we related how biophysical and biochemical properties affected by the SRY mutation relate to the regulation of a gene - regulatory network in a biological system.»

The researchers demonstrated the efficiency of the chip laboratory using a model system of gene regulation, the Lac - Operon.

Instead, viruses mute the immune system by epigenetic regulation — instead of changing the actual code of genes, viruses change the degree to which genes are expressed.

The results may offer insights into gene regulation and other systems important to mammalian biology.

Future inquiry also relates to cephalopod genes and regulation relevant to the development and functioning of the nervous system.

The publication of the latest Canine genome build and annotation, CanFam3.1 provides an opportunity to enhance our understanding of gene regulation across tissues in the dog model system.

Wolf and his colleagues have used the CRISPR - Cas9 system in bovine embryos to delete OCT4, a gene that is known to play a key role in the regulation of pluripotency in mammalian embryos.

The regulatory system to control redox balance involves sugar - dependent gene regulation and protein phosphorylation.

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

This is consistent with work in other systems that showed transcripts from BR biosynthesis genes accumulated following loss of BR due to negative feedback regulation (Bancoş et al., 2002; Tanabe et al., 2005; Tanaka et al., 2005).

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

What is known from global studies is that exposure to biologically active compounds, even at ng / L concentrations, can impact endocrine systems in nature and manifest as negative impacts like altered gene regulation, the presence of mixed reproductive tissues (intersex) and skewed sex ratios.

A recent review in the journal Genes & Development summarizes additional functions of the lymphatic system in fat metabolism, obesity, inflammation, and the regulation of salt storage in hypertension.

With her recent groundbreaking findings in the field of RNA - mediated regulation based on the CRISPR - Cas9 system, E. Charpentier has laid the foundation for the development of a novel, highly versatile and specific genome editing technology that is revolutionizing life sciences research and could open up whole new opportunities in biomedical gene therapies.

The main research focus of the single molecule group is the study of molecular motors, the role of force in regulating biological systems, and the molecular mechanisms of gene expression regulation.

Helicobacter pylori induces hyperproliferation in a three - dimensional culture system in conjunction with up - regulation of ß - catenin target genes.

This observation and the availability of a reference rabbit genome allowed us to identify several candidate genes for reproductive isolation in this system that suggest an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.

The Marsh - Armstrong laboratory studies molecular mechanisms involved in gene regulation, development and disease of the central nervous system, focusing principally on the retina.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

In 2006, she became a Research Fellow at the Hormone Action and Oncogenesis group at the LRBGE and extended her work on GR biology and GR - target genes regulation in response to the ultradian secretion of glucocorticoids occurring naturally in mammalian systems.

H2 supports the body's in - house antioxidant system through selective activation of specific cell - signaling pathways that are thought to contribute to the regulation of a «wide variety of antioxidant, detoxification, and cell survival genes.»

Studies to date have demonstrated that phytochemicals in common fruit and vegetables can have complementary and overlapping mechanisms of action, including modulation of detoxification enzymes, scavenging of oxidative agents, stimulation of the immune system, regulation of gene expression in cell proliferation and apoptosis, hormone metabolism, and antibacterial and antiviral effects (15, 16).

«Given the transactional nature of the regulation of interrelated biological systems, and our findings of associations between flatter DCS (lower morning peak in cortisol and / or higher even cortisol levels) and multiple health outcomes, it seems plausible that reciprocal and cascading interactions among clock gene mechanisms, sleep, cortisol, inflammation, fatigue, appetite, behavior, and social and psychological experiences jointly contribute to the observed associations between flatter DCS and multiple types of negative health outcomes.»

``... several animal studies indicate serious health risks associated with GM food consumption including infertility, immune dysregulation, accelerated aging, dysregulation of genes associated with cholesterol synthesis, insulin regulation, cell signaling, and protein formation, and changes in the liver, kidney, spleen and gastrointestinal system.»

We examine alterations in biological stress regulatory systems; alterations in the neural regulation of stress responses; and expression of genes related to stress responses, both as latent indicators of impending health risks and as indicators of psychological and biological stress - reactive processes that may accelerate those risks.