Sentences with phrase «gene regulation through»

Small stretches of about 22 nt non-coding RNA, so - called microRNA or miRNA, are important for gene regulation through its binding to coding RNA sequences.

Expression changes of these genes suggest a possible form of gene regulation through the alteration of the chromatin structure.

Not exact matches

This finding by Whitehead Institute scientists challenges current understandings of gene regulation via DNA methylation, from development through adulthood.

However, scientists have recently found that gene regulation can also happen in an ongoing fashion through epigenetic processes, with the potential to change behavior throughout a lifetime.

The regulation of gene expression, for example, is extremely difficult to study through the genome alone.

At the nucleic acid level, understanding the precise regulation of genes through analysis of gene expression data will be of utmost importance.

«This study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases, at least psychologically, through regulation of the Ppm1f gene» he adds.

«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the regulation of the transcription of many genes,» said principal investigator Denise Al Alam, PhD, of the Department of Surgery and the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute.

Although the biological mechanisms through which this polymorphism could affect aging are not known, it is adjacent to two genes called CDKN2A and CDKN2B, which play an important role in cell cycle regulation.

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

BR homeostasis is controlled through transcriptional feedback regulation of these biosynthetic genes by known BR signaling TFs, BRASSINAZOLE RESISTANT1 (BZR1) and BRI1 - EMS - SUPPRESSOR1 (BES1) / BZR2.

Researchers find Nrf2, a stress response gene, to be a pluripotency gene which mediates its effects through regulation of the proteasome

DDX3 enhances p21waf1 / cip1 gene expression through up - regulation of promoter activity of p21waf1 / cip1.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

cell types may have evolved through cooption of temporal gene regulation in an ancestor whose different phases were converted into germ - and soma - specific expression programs.

«In a way, we're modeling one mechanism through which genes affect disease or traits, which is the regulation of gene expression level.»

These results suggest that V. carteri cell types may have evolved through cooption of temporal gene regulation in an ancestor whose different phases were converted into germ - and soma - specific expression programs.

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Developmental regulation proceeds through the sequential activation of a series of regulatory switches that in turn activate networks of other genes.

Beginning with the pathogen pattern recognition receptors (PPRRs), the signal travels like clockwork through various molecular components and culminates in interferon beta gene regulation.

Through this packaging mechanism, researchers think that histone proteins are the key to regulating access to the genetic information by making different parts of the DNA accessible to factors that express the gene, so - called epigenetic regulation.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

The retinoic acid — induced gene G (RIG - G), also known as IFN - inducible gene 60, was originally identified in all - trans retinoic acid (ATRA)-- treated NB4 acute promyelocytic leukemia (APL) cells (1) and plays an important role in cell growth inhibition through up - regulation of p21 and p27 (2).

This gene appears to contribute to obesity through the regulation of appetite.

Although the mechanism of age - related decline in DNA repair capacity is unknown, growing evidence suggests that epigenetic events (e.g., DNA methylation) contribute to the ageing process and may be functionally important through the regulation of the expression of DNA repair genes.

Leishmania lacks classical regulation of transcription at initiation through promoters, so aneuploidy could represent a major adaptive strategy of this parasite to modulate gene dosage in response to stressful environments.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment diThrough this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dithrough direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

Importantly, there is a clear signature of the parents» sensitivity to high CO2 in the molecular phenotype of the offspring expressed by the differential regulation of genes controlling the circadian rhythm indicating adaptive potential through natural standing variation.

H2 supports the body's in - house antioxidant system through selective activation of specific cell - signaling pathways that are thought to contribute to the regulation of a «wide variety of antioxidant, detoxification, and cell survival genes.»

We want to understand this observation through the investigation of gene regulation in the context of the epigenetic landscape.