Sentences with phrase «gene regulation using»

He has made fundamental contributions to our understanding of vertebrate developmental biology and microRNA - based gene regulation using the model organism zebrafish.

Not exact matches

Using blood samples, the study found that regulation of the oxytocin receptor gene OXTR was associated with development of the condition.

This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

However, to make use of that information required an understanding of gene expression and regulation, areas in which institute members made a conscious decision to invest and that became its strengths.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

«The development, risk assessment regulation, and use of gene drives should be based on public dialog, public deliberations, and public decision - making.

To achieve this, the researchers took advantage of a phenomenon known as quorum sensing, which is used by many species of bacteria to coordinate gene regulation in response to their population density.

The researchers demonstrated the efficiency of the chip laboratory using a model system of gene regulation, the Lac - Operon.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona (INc - UAB) and the Vall d'Hebron Research Institute (VHIR) are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age - related learning and memory problems in mice.

Further studies are needed to determine whether the specific use of transcription starting points is a widely disseminated mechanism for gene regulation.

They write that the U.S. National Academy of Sciences has recently convened a panel to discuss the potential hazards and regulation of gene drives, and to make recommendations regarding their safe use.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

«Using this approach, we will eventually be able to do the same thing you would do in English class — pick up a book of haiku or Shakespeare and understand that «this is a love poem,» or «this is an elegy,» because we'll understand how the words — the DNA elements — are used in different contexts to convey different meanings on the regulation of genes,» Arnosti said.

Researchers from the INc - UAB and the VHIR are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age - related learning and memory problems in mice.

Using this «Ribotag» approach tissue - specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially regulated genes.

Scientists have discovered many points of regulation in the process of using a specific DNA template to make a protein, known as gene expression, that allow the cell to control how much of a certain protein is made at a certain time.

Wolf and his colleagues have used the CRISPR - Cas9 system in bovine embryos to delete OCT4, a gene that is known to play a key role in the regulation of pluripotency in mammalian embryos.

The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to study fundamental processes involved in gene regulation.

This work is one basis for the use in the scientific community of transgenes as a major technique to study gene regulation in normal and malignant cells.

To understand and analyze the regulation of gene expression patterns, quantitative RNA sequencing is used.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

Using databases created by other labs, the Duke University scientists cross-checked areas of human DNA that had developed differences from chimp DNA with areas of DNA they expected to be important for gene regulation.

Using drug repurposing, Yoshimura's group not only identified circadian rhythm changing drugs, but also succeeded in identifying genes that are involved in the regulation of the circadian clock.

October 17, 2013 Gene regulation differences between humans and chimpanzees more complex than thought Changes in gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical Gene regulation differences between humans and chimpanzees more complex than thought Changes in gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical DNA.

Steve's research focuses on polyploid crops where he uses genomics and bioinformatics approaches to examine chromatin structure and the effect it has on gene regulation.

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

Our colleagues at Gladstone are using this knowledge to search for small molecules that can affect gene regulation and reverse some of the problems caused by the loss of these transcription factors.»

We confirmed the role of Nrf2 in the regulation of HMOX1 gene expression by HPP - 4382 using genetic silencing of Nrf2.

We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

According to these regulations, gene modified animals are housed in specific units, their use is registered and reported to the authorities, and inspections are performed on a regular basis.

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

The latest study, published in Cell Stem Cell, offers a third way to turn skin cells into stem cells by directly manipulating the cells» genome using CRISPR gene regulation techniques.

A basic understanding on the set of genes and gene networks responsible from directly regulating lifespan and the mechanisms used in this regulation is also missing.

Bacterial gene regulation has so far been investigated largely using exposure to artificial environmental conditions or to in vitro cultured cells, and little information is available on how S. enterica adapts in vivo to sustain cell division and survival.

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to certain chemotherapy agents.

In their laboratory they use genomic, genetic and biochemical approach to identify the genes which fall under circadian rhythm regulation in various organs in our body and to delve into what goes on behind that regulation.

Finally, because we did not measure gene expression, the current results await replication and extension using methods that can clarify whether the observed effects are associated with changes in gene expression that would indicate up or down regulation of TNF.