Sentences with phrase «gene regulators implicated»
I am particularly interested in the neuronal tissue and the analysis of gene regulators implicated in both differentiation and brain tumor development.
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For example, in the case of the protein SIN3A, a regulator of gene transcription, the small molecule that covalently binds to its reactive lysine blocks the protein's function by disrupting SIN3A's interaction with another protein, TGIF1 — an interaction implicated in some invasive breast cancers.
In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2).
This implicates putative master regulator genes in which multiple independent stop codon mutations have convergently led to culture adaptation, affecting most laboratory lines of P. falciparum.