Sentences with phrase «gene regulators in»

Freiburg researchers map out the atlas of gene regulators in human cardiac cells for the first time

For the first time, a research team led by Dr. Ralf Gilsbach and Prof. Dr. Lutz Hein from the Institute of Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg have mapped out the gene regulators in the DNA of human cardiac muscle cells.

Not exact matches

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Rho, found in many bacteria, acts as a protein regulator of bacterial gene expression, determining which genes get turned on or off.

In the right image the labyrinth is compact and its branching is impaired, because the gene regulator Grhl2 was inactivated.

In this system bacteria secrete compounds called autoinducer peptides (AIPs) that are detected by receptor proteins called accessory gene regulator (Agr) kinases.

«Now it's important to do the downstream work of validating these master regulators in the lab before we can test these genes in experimental models,» says Dr. Papapanou.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtIn addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtin the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

In mice, when the researchers inactivated the gene regulator GRHL2 in the fetal part of the placenta and in the embryo, the development of the labyrinth was severely disrupteIn mice, when the researchers inactivated the gene regulator GRHL2 in the fetal part of the placenta and in the embryo, the development of the labyrinth was severely disruptein the fetal part of the placenta and in the embryo, the development of the labyrinth was severely disruptein the embryo, the development of the labyrinth was severely disrupted.

He proved that the BCL6 gene was like an on and off switch, or master regulator, that triggered the production of Tfh cells, which in turn told the B cells to make more antibodies.

When the researchers inactivated the gene regulator only outside the placenta in the embryo, the labyrinth developed normally.

Regulators in the US could soon be asked to approve a human trial of gene therapy for cystic fibrosis that uses a hybrid of the HIV and Ebola viruses.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

While miRNAs are generally negative regulators of gene expression in eukaryotes, they also negatively regulate larval development when honeybee larvae consume beebread / pollen and take up plant miRNAs.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

The study suggests that a less common version of the BDNF gene may predispose people to obesity by producing lower levels of BDNF protein, a regulator of appetite, in the brain.

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

«New major gene expression regulator in fungi: Researchers report prevalent DNA base modification in the earliest fungal lineages.»

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

Cystic fibrosis is a rare inherited disease caused by mutations in a single gene called cystic fibrosis transmembrane conductance regulator (CFTR) and affects 1 in every 2500 newborns in the UK and over 90000 people worldwide.

Rett syndrome is a neurodevelopmental disorder that is caused primarily by mutations in the gene encoding for MeCP2, an important epigenetic regulator.

This pharyngeal gene cluster contains six genes ordered in a common pattern in all deuterostomes and includes the genes for four proteins that are critical transcriptional regulators that control activation of numerous other genes.

The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

«While many genes have been identified as genetic regulators of sleep or metabolic state, mounting evidence from our study indicates that translin functions as a unique integrator of these processes,» said Kazuma Murakami, co-first author and a Ph.D. student in the FAU / Max Planck Florida Institute Integrative Biology and Neuroscience (IBAN) program.

In the past five years, European regulators have approved two gene therapies - the first of their kind in the world, outside China - but only three patients have so far been treated commerciallIn the past five years, European regulators have approved two gene therapies - the first of their kind in the world, outside China - but only three patients have so far been treated commerciallin the world, outside China - but only three patients have so far been treated commercially.

After decades of development, regulators have recommended approval for the first commercial gene therapy in Europe and the US.

In 2008, Dr. Côté's team explained the role of the DOCK1 and DOCK5 genes in the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in micIn 2008, Dr. Côté's team explained the role of the DOCK1 and DOCK5 genes in the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in micin the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in micin mice.

It comprises nearly 35,000 genes, including the full set of oil biosynthesis genes and other transcriptional regulators highly expressed in the oil - rich palm fruit.

«People are more understanding of this research,» says Fan, who points to UK fertility regulators» approval in February of a proposal by developmental biologist Kathy Niakan to edit genes in healthy human embryos, at the Francis Crick Institute in London.

Co-first author, Dr Stephen Clark, a post-doctoral researcher at the Babraham Institute, said: «Methods for studying gene expression or epigenetic regulators in individual cells are quite established.

«Surprising role of gene regulator protein in development of skin tumors.»

SP110 is a regulator of gene expression, mainly in immune cells.

Niakan's group focused on a gene called OCT4 (also known as POU5F1), a master regulator of gene activity, which is important in mouse embryo development.

Last year, government regulators in the United Kingdom gave permission for Niakan, a developmental biologist at the Francis Crick Institute in London, and colleagues to perform gene editing on human embryos left over from in vitro fertilization treatments (SN Online: 2/1/16).

When committee member Jennifer Kuzma, a policy analyst at North Carolina State University in Raleigh, asked what exactly represents a «different type of risk» from existing products, several regulators invoked another nascent technology, known as gene drive.

In 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquIn 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin response to calorie restriction, which Sinclair calls a «master regulator in aging.&raquin aging.»

Defects in this gene mean it can no longer fulfil its role as a regulator that helps purge the body of autoreactive immune cells termed T cells that can react against the body's own proteins, mistaking them for a foreign invader.

Other fast - changing genes — roughly 100 — are associated with neurotransmitters, including serotonin (a mood regulator), glutamate (involved in general arousal), and dopamine (which regulates attention).

Mutation of a bacterial flagellar regulator gene can be compensated for by changes in a related nitrogen uptake regulator.

To find out what these genes do, and which ones are master regulators of development, researchers have several approaches, including deactivating embryonic genes in mice.

I am particularly interested in the neuronal tissue and the analysis of gene regulators implicated in both differentiation and brain tumor development.

Much of this DNA is no longer capable of moving, but is likely «auditioning» perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA, nucleotide sequences, are exchanged between two DNA molecules to repair breaks in the DNA strands.

In addition, they also found that several important histone regulator genes such as MLL2, ASH1L, MLL3, SETD1B and CREBBP / EP300 are frequently altered in ESCIn addition, they also found that several important histone regulator genes such as MLL2, ASH1L, MLL3, SETD1B and CREBBP / EP300 are frequently altered in ESCin ESCC.

«Gene regulator is key to healthy retinal development and good vision in adulthood.»

Steve Gerondakis and colleagues establish that Rel (from the c - rel gene) in mice is a positive or negative regulator of transcription in macrophages and that Rel has distinct roles in different macrophage populations.